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List of works by Joan X. Comella

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

scientific article

A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-XL Overexpression in motoneurons

scientific article published in June 2011

A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.

scientific article published on 19 February 2013

Absence of histochemical immunoreactivity to calcitonin gene-related peptide (CGRP) in spinal cord motoneurons from (+)-tubocurarine-treated chick embryos

scientific article published on 01 October 1989

Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells

scientific article published on 23 June 2009

Activation of phosphatidylinositol 3-kinase, but not extracellular-regulated kinases, is necessary to mediate brain-derived neurotrophic factor-induced motoneuron survival

scientific article

Activation-induced cell death in T lymphocytes from multiple sclerosis patients

scientific article published on 16 April 2014

Amyloid Beta, TNFα and FAIM-L; Approaching New Therapeutic Strategies for AD.

scientific article published on 18 December 2014

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death. ⬇️

scientific article published on 12 February 2015

An alternative view of apoptosis in heart development and disease

scientific article published on 20 November 2007

Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons.

scientific article

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease

scientific journal article

BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs

scientific article published in October 2008

Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells.

scientific article published on April 2004

Bcl-2 is a key factor for cardiac fibroblast resistance to programmed cell death.

scientific article

Binding patterns of lectins with GalNAc specificity in the mouse dorsal root ganglia and spinal cord

scientific article published in 1999

Calmodulin Is Involved in Membrane Depolarization-Mediated Survival of Motoneurons by Phosphatidylinositol-3 Kinase- and MAPK-Independent Pathways ⬇️

scientific article published on February 15, 1998

Calmodulin Modulates Mitogen‐Activated Protein Kinase Activation in Response to Membrane Depolarization in PC12 Cells ⬇️

scientific article published on June 1, 1998

Characterization of the Cell Death Process Induced by Staurosporine in Human Neuroblastoma Cell Lines ⬇️

scientific article published on June 1, 1997

Combined use of the green and yellow fluorescent proteins and fluorescence-activated cell sorting to select populations of transiently transfected PC12 cells

scientific article published on 01 July 2000

Cytokines Promote Motoneuron Survival through the Janus Kinase-Dependent Activation of the Phosphatidylinositol 3-Kinase Pathway ⬇️

scientific article published on December 1, 2001

Cytosine arabinoside is neurotoxic to chick embryo spinal cord motoneurons in culture

scientific article published on 01 February 1997

Development of Survival Responsiveness to Brain-Derived Neurotrophic Factor, Neurotrophin 3 and Neurotrophin 4/5, But Not to Nerve Growth Factor, in Cultured Motoneurons from Chick Embryo Spinal Cord ⬇️

scientific article published on October 1, 1998

Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues

scientific article published on 26 November 2007

Differential involvement of phosphatidylinositol 3-kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic effects on cultured striatal neurons.

scientific article published in March 2004

Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development

scientific article published in November 2007

Effects of stonefish (Synanceia trachynis) venom on murine and frog neuromuscular junctions.

scientific article published in March 1993

EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes

scientific article

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

scientific article

Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer’s Disease

scientific article published on January 2015

FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.

scientific article published on December 2013

FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration

scientific article (publication date: 21 October 2016)

FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons

scientific article published on 21 May 2015

FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis

scientific article

Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system

scientific article published on 6 July 2016

Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease

scientific article published on 13 November 2019

Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

scientific article published on 20 November 2003

Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe.

scientific article

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

scientific journal article

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells

scientific journal article

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment

scientific article

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness

scientific article

Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner.

scientific article published in May 2007

Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase.

scientific article published in March 2003

NF-κB activation fails to protect cells to TNFα-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w

scientific article published on 28 January 2013

Nerve growth factor activation of the extracellular signal-regulated kinase pathway is modulated by Ca(2+) and calmodulin.

scientific article published on March 2000

Nerve terminal sprouting in botulinum type-A treated mouse levator auris longus muscle

scientific article published on 01 May 1996

Neurobehavioral characterization of Endonuclease G knockout mice reveals a new putative molecular player in the regulation of anxiety

scientific article published on 18 April 2013

Neurodegeneration and neuroinflammation: two processes, one target

scientific article published on October 2015

Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV.

scientific article

Outlining the nascent nervous system of Branchiostoma floridae (amphioxus) by the pan-neural marker AmphiElav

scientific article published on 2 April 2005

Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation

scientific article

Phylogenetic polymorphism on lectin binding to junctional and non-junctional basal lamina at the vertebrate neuromuscular junction.

scientific article

Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.

scientific article published on 15 December 2006

Receptors to agglutinin from Dolichus biflorus (DBA) at the synaptic basal lamina of rat neuromuscular junction. A histochemical study during development and denervation.

scientific article

Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.

scientific article

Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation

scientific article published on 2 March 2006

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L

scientific article published on 03 February 2020

Serum Deprivation and Protein Synthesis Inhibition Induce Two Different Apoptotic Processes in N18 Neuroblastoma Cells

scientific article published in February 1998

Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential beta-catenin phosphorylation.

scientific article published on 29 July 2008

Specific vulnerability of mouse spinal cord motoneurons to membrane depolarization.

scientific article published on 13 July 2009

Sprouting of mammalian motor nerve terminals induced by in vivo injection of botulinum type-D toxin and the functional recovery of paralysed neuromuscular junctions

scientific article published on 01 April 1993

Switch from caspase-dependent to caspase-independent death during heart development: essential role of endonuclease G in ischemia-induced DNA processing of differentiated cardiomyocytes

scientific article published on 05 June 2006

Synaptic localization of a 66-kDa soluble protein from skeletal muscle: evidence for its developmental and neural regulation

scientific article published in August 1989

Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip.

scientific article published on 4 September 2012

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.

scientific article published on 19 March 2015

Terminal sprouting in mouse neuromuscular junctions poisoned with botulinum type A toxin: morphological and electrophysiological features

scientific article published on 01 January 1990

Tetrodotoxin-sensitive ciguatoxin effects on quantal release, synaptic vesicle depletion, and calcium mobilization

scientific article published in January 1991

The absence of oligonucleosomal DNA fragmentation during apoptosis of IMR-5 neuroblastoma cells: disappearance of the caspase-activated DNase.

scientific article published on 6 April 2001

The carbohydrate N-acetylglucosamine is involved in the guidance of neurites from chick ciliary ganglion neurons through the extracellular matrix of rat skeletal muscle fiber

scientific article published on 01 March 1996

The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling

scientific journal article

The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins

scientific journal article

The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis.

scientific article published in October 2007

The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells.

scientific article published in January 2002

The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells.

scientific article published on 30 March 2005

Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway ⬇️

scientific article published on July 28, 2012

Trk is a calmodulin-binding protein: implications for receptor processing.

scientific article published in January 2004

Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function.

scientific article published in January 2008

Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling

scientific journal article

X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk.

scientific article published on January 2013

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