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List of works by Raquel Seiça

A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia.

scientific article

A vascular piece in the puzzle of adipose tissue dysfunction: mechanisms and consequences

scientific article

Adiponectin and sporadic Alzheimer's disease: Clinical and molecular links.

scientific article published on 13 October 2017

Adiponectin improves endothelial function in mesenteric arteries of rats fed a high-fat diet: role of perivascular adipose tissue

scientific article published on 25 February 2017

Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation.

scientific article

Alterations of liver mitochondrial bioenergetics in diabetic Goto-Kakizaki rats

scientific article published on 01 September 1999

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

scientific article published on 21 June 2016

Amelioration of glycemic control by sleeve gastrectomy and gastric bypass in a lean animal model of type 2 diabetes: restoration of gut hormone profile

scientific article published in January 2015

Association between Adipokines and Biomarkers of Alzheimer's Disease: A Cross-Sectional Study

scientific article published on 01 January 2019

Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia

scientific article

Beneficial effects of dietary restriction in type 2 diabetic rats: the role of adipokines on inflammation and insulin resistance.

scientific article

Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress.

scientific article

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

scientific article published on 20 February 2007

Calcium-dependent mitochondrial permeability transition is augmented in the kidney of Goto-Kakizaki diabetic rat

scientific article published on 01 March 2004

Childhood adiposity: being male is a potential cardiovascular risk factor.

scientific article

Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes

scientific article published in November 2010

Circulating endothelial progenitor cells in obese children and adolescents

scientific article published on 29 August 2015

CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats.

scientific article published on 29 August 2005

Common mechanisms of dysfunctional adipose tissue and obesity-related cancers.

scientific article published on May 2013

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

scientific article published on 26 February 2019

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia.

scientific article published on 8 July 2010

Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate

scientific article published on 01 February 2001

Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: relationship to mitochondrial antioxidant capacity.

scientific article published on January 1999

Diabesity and Brain Energy Metabolism: The Case of Alzheimer's Disease

scientific article published on January 2017

Diabetes and mitochondrial bioenergetics: alterations with age.

scientific article published in January 2003

Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat.

scientific article published on April 2003

Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents

scientific article published in October 2003

Diabetes mellitus: new challenges and innovative therapies

scientific article

Dietary restriction improves systemic and muscular oxidative stress in type 2 diabetic Goto-Kakizaki rats

scientific article published on 23 June 2011

Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin

scientific article published on 10 April 2016

Dyslipidemia and cardiovascular changes in children

scientific article

Editorial: Oxidative Stress Revisited-Major Role in Vascular Diseases

scientific article published on 21 June 2019

Effect of Sleeve Gastrectomy on Angiogenesis and Adipose Tissue Health in an Obese Animal Model of Type 2 Diabetes

scientific article published on 01 September 2019

Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.

scientific article published on October 2007

Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes

scientific article published on 24 July 2006

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status.

scientific article published on 17 May 2014

Effects of teduglutide on histological parameters of intestinal anastomotic healing

Endothelial dysfunction - a major mediator of diabetic vascular disease

scientific article published on 29 August 2013

Endothelial dysfunction in type 2 diabetes: effect of antioxidants

scientific article published on 01 June 2007

Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats

scientific article published in November 2003

Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats.

scientific article

Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats

scientific article published on 28 May 2019

Food deprivation promotes oxidative imbalance in rat brain

scientific article published in January 2009

Function and Dysfunction of Adipose Tissue

scientific article published in January 2017

Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver.

scientific article

Glucagon secretion after metabolic surgery in diabetic rodents.

scientific article published in October 2014

High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: An in vivo multimodal MRI study.

scientific article published on 26 January 2018

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).

scientific article published in August 2003

Hyperresistinemia and metabolic dysregulation: a risky crosstalk in obese breast cancer.

scientific article

Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters

scientific article published on 20 October 2010

Impact of the in vitro gastrointestinal passage of biopolymer-based nanoparticles on insulin absorption

scholarly article in RSC Advances, vol. 6 no. 24, 2016

Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate

scientific article

In vivo biodistribution of antihyperglycemic biopolymer-based nanoparticles for the treatment of type 1 and type 2 diabetes.

scientific article published on 19 December 2016

Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure.

scientific article published in June 2003

Insulin affects synaptosomal GABA and glutamate transport under oxidative stress conditions

scientific article

Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats

scientific article

Insulin attenuates diabetes-related mitochondrial alterations: a comparative study.

scientific article published in May 2006

Insulin protects against amyloid beta-peptide toxicity in brain mitochondria of diabetic rats.

scientific article published on April 2005

Insulin resistance and beta cell function before and after sleeve gastrectomy in obese patients with impaired fasting glucose or type 2 diabetes

scientific article published on 4 July 2014

Insulin resistance is associated with tissue-specific regulation of HIF-1α and HIF-2α during mild chronic intermittent hypoxia

scientific article published on 15 March 2016

Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children

scientific article published on 23 January 2015

Intermedin elicits a negative inotropic effect in rat papillary muscles mediated by endothelial-derived nitric oxide

scientific article published on 06 January 2012

Intestinal Epithelial Stem Cells: Distinct Behavior After Surgical Injury and Teduglutide Administration.

scientific article

Intestinal absorption of insulin nanoparticles: contribution of M cells.

scientific article published on 12 March 2014

Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats

scientific article

Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications to Adipose Tissue: Muscle Crosstalk

scientific article published on 5 May 2015

Lipoic Acid Prevents High-Fat Diet-Induced Hepatic Steatosis in Goto Kakizaki Rats by Reducing Oxidative Stress Through Nrf2 Activation

scientific article published on 11 September 2018

Long-term globular adiponectin administration improves adipose tissue dysmetabolism in high-fat diet-fed Wistar rats

scientific article published on 21 August 2014

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview

scientific article

Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia.

scientific article published in January 2011

Metformin promotes isolated rat liver mitochondria impairment.

scientific article published on 2 October 2007

Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.

scientific article published in July 2008

Metformin restores endothelial function in aorta of diabetic rats

scientific article

Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity

scientific article published on 27 February 2012

Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats.

scientific article published on 30 April 2013

Methylglyoxal further impairs adipose tissue metabolism after partial decrease of blood supply

scientific article published on 11 July 2013

Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

scientific article published on 16 September 2016

Methylglyoxal promotes oxidative stress and endothelial dysfunction

scientific journal article

Methylglyoxal, obesity, and diabetes

scientific article published on 16 September 2012

Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance.

scientific article

Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.

scientific article published on 18 June 2010

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology.

scientific article published on 11 October 2016

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

scientific article published on July 2016

Mitochondrial Bioenergetics, Diabetes, and Aging: Top-Down Analysis Using the Diabetic Goto-Kakizaki (GK) Rat as a Model

scientific article published in January 2006

Mitochondrial function is not affected by renal morphological changes in diabetic goto-kakizaki rat.

scientific article published in January 2005

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes.

scientific article published on 16 May 2014

Modulation of glucose-induced insulin secretion by cytosolic redox state in clonal beta-cells.

scientific article published on August 1999

Neuroendocrinology of Adipose Tissue and Gut-Brain Axis

scientific article

Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines

scientific article published on 20 February 2014

Oxidative stress affects synaptosomal gamma-aminobutyric acid and glutamate transport in diabetic rats: the role of insulin

scientific article

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

scientific article published on 14 September 2014

Phytoestrogen coumestrol improves mitochondrial activity and decreases oxidative stress in the brain of ovariectomized Wistar-Han rats

Preparation methods and applications behind alginate-based particles

scientific article

Pro-inflammatory triggers in childhood obesity: Correlation between leptin, adiponectin and high-sensitivity C-reactive protein in a group of obese Portuguese children

article

Probing insulin bioactivity in oral nanoparticles produced by ultrasonication-assisted emulsification/internal gelation.

scientific article

Pyridoxamine reverts methylglyoxal-induced impairment of survival pathways during heart ischemia.

scientific article published in December 2013

Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies?

scientific article published on January 2003

Reduction of methylglyoxal-induced glycation by pyridoxamine improves adipose tissue microvascular lesions

scientific article published on 7 April 2013

Reverse myocardial effects of intermedin in pressure-overloaded hearts: role of endothelial nitric oxide synthase activity

scientific article published on 19 November 2012

Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat.

scientific article published on 5 June 2007

Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets.

scientific article published on 26 August 2007

Subcutaneous delivery of biotherapeutics: challenges at the injection site

scientific article published on 24 January 2019

Subcutaneous delivery of monoclonal antibodies: How do we get there?

scientific article published on 02 August 2018

Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats.

scientific article published in February 2008

Susceptibility to beta-amyloid-induced toxicity is decreased in goto-kakizaki diabetic rats: involvement of oxidative stress.

scientific article published on January 2000

Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis

scientific article published on 4 May 2017

The Force at the Tip--Modelling Tension and Proliferation in Sprouting Angiogenesis

scientific article

The Role of Brain in Energy Balance

scientific article

The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes

scientific article published on 30 October 2017

The effect of soybean oil on glycaemic control in Goto-kakizaki rats, an animal model of type 2 diabetes.

scientific article published in May 2008

Therapeutic association of atorvastatin and insulin in cardiac ischemia: study in a model of type 2 diabetes with hyperlipidemia.

scientific article published on 23 July 2008

Type 2 diabetes aggravates Alzheimer's disease-associated vascular alterations of the aorta in mice.

scientific article

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects

scientific article

Using Resistin, glucose, age and BMI to predict the presence of breast cancer.

scientific article published on 4 January 2018

Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats

scientific article published in May 2004

Why most oral insulin formulations do not reach clinical trials.

scientific article published on 14 August 2015

[Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach].

scientific article published on 31 October 2017

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