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List of works by James L Wynn

A prime time for trained immunity: innate immune memory in newborns and infants.

scientific article published on 18 December 2013

Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation.

scientific article

Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA.

scientific article

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

scientific article published on 01 May 2020

Beyond bacteria: a study of the enteric microbial consortium in extremely low birth weight infants

scientific article

Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants ⬇️

scientific article published on January 31, 2013

Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.

scientific article

Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality

article

Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists.

scientific article published on 30 June 2008

Defining neonatal sepsis

scientific article published on 13 January 2016

Does IVIg administration yield improved immune function in very premature neonates?

scientific article published on 07 January 2010

Early Sepsis Does Not Increase the Risk of Late Sepsis in Very Low Birth Weight Neonates ⬇️

scientific article published on January 5, 2013

Early administration of oropharyngeal colostrum to extremely low birth weight infants.

scientific article published on 27 June 2013

Fanning the Fire: Can Methemoglobin Enhance Neutrophil Activation?

scientific article published on 2 February 2015

Genome-wide association study of sepsis in extremely premature infants

scientific article

Great expectorations: the potential of salivary 'omic' approaches in neonatal intensive care

scientific article published on 09 January 2014

Heart rate characteristic index monitoring for bloodstream infection in an NICU: a 3-year experience

scientific article published on 30 October 2015

Histological chorioamnionitis shapes the neonatal transcriptomic immune response.

scientific article published on 15 June 2016

Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches.

scientific article published on 07 February 2017

Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.

scientific article

Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis

scientific article published in December 2007

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

scientific article

Infectious causes of necrotizing enterocolitis.

scientific article

Lethal neonatal meningoencephalitis caused by multi-drug resistant, highly virulent Escherichia coli. ⬇️

scientific article

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.

scientific article published on 08 August 2016

Mechanisms and regulation of the gene-expression response to sepsis.

scientific article published on 17 May 2010

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis

scientific article

Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality.

scientific article published on 22 June 2015

Neutrophil chemotaxis and transcriptomics in term and preterm neonates

scientific article published in September 2017

Oral colostrum priming shortens hospitalization without changing the immunomicrobial milieu

scientific article published on 29 September 2016

Outcomes Following Candiduria in Extremely Low Birth Weight Infants ⬇️

scientific article published on December 5, 2011

Pathophysiology and treatment of septic shock in neonates.

scientific article

Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis

scientific article

Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis.

scientific article published on 04 September 2008

Probiotic microbes: do they need to be alive to be beneficial?

scientific article published on September 2009

Progress in the management of neonatal sepsis: the importance of a consensus definition

scientific article published on 11 October 2017

Reappraisal of guidelines for management of neonates with suspected early-onset sepsis.

scientific article published on 29 January 2015

Role of Innate Immunity in Neonatal Infection ⬇️

scientific article published on January 7, 2013

Role of innate host defenses in susceptibility to early-onset neonatal sepsis.

scientific article

Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles.

scientific article

TLRs, SNPs and VLBWs: oh my!

scientific article published on October 2013

TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis

scientific article

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

scientific article published on 25 April 2016

The Influence of Developmental Age on the Early Transcriptomic Response of Children with Septic Shock ⬇️

scientific article published on July 5, 2011

The host response to sepsis and developmental impact

scientific article

Time for a neonatal-specific consensus definition for sepsis.

scientific article

Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis

scientific article published on 6 December 2016

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.

scientific article

Unique transcriptomic response to sepsis is observed among patients of different age groups.

scientific article published on 8 September 2017

Use of a computerized C-reactive protein (CRP) based sepsis evaluation in very low birth weight (VLBW) infants: a five-year experience

scientific article

Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis

scientific article published on 13 April 2017

Why are preterm newborns at increased risk of infection?

scientific article

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