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List of works by Nicole Déglon

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alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

scientific article
Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

scientific article published in June 1996
Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

scientific article published on 2 March 2014
Lentiviral-mediated RNA interference

scientific article published on December 2002
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

scientific article
Sustained effects of nonallele-specific Huntingtin silencing

scientific article published on March 2009
Isolation of multipotent neural precursors residing in the cortex of the adult human brain.

scientific article
Mitochondria in Huntington's disease

scientific article published on 11 August 2009
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

scientific article
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

scientific article
Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.

scientific article published in June 2001
Gene transfer into neurons from hippocampal slices: comparison of recombinant Semliki Forest Virus, adenovirus, adeno-associated virus, lentivirus, and measles virus.

scientific article published in May 2001
Akt is altered in an animal model of Huntington's disease and in patients

scientific article published in March 2005
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

scientific article published on 30 January 2014
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

scientific journal article
BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.

scientific article published on 30 April 2013
Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

scientific article
Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

scientific article
Engineered lentiviral vector targeting astrocytes in vivo

scientific article
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

scientific article published on February 2015
Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

scientific article published on 01 May 2000
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

scientific article
Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.

scientific article
Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

scientific article published on June 2002
Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

scientific article published in February 2006
Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

scientific article published in September 2008
Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

scientific article published on September 2002
Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

scientific article published on 11 July 2005
Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

scientific article
Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

scientific article published on 22 March 2010
Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo

scientific article
Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

scientific article published in November 2002
Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression

scientific article
A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

scientific article published on 29 May 2013
Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time

scientific article
Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

scientific article published in August 2012
Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

scientific article
Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

scientific article
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice

scientific article
Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

scientific article published on 11 February 2008
Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

scientific article published on 14 July 2005
Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

scientific article published in July 2013
Seizure suppression by adenosine-releasing cells is independent of seizure frequency

scientific article published in August 2002
Implication of the JNK pathway in a rat model of Huntington's disease

scientific article
Minocycline in phenotypic models of Huntington's disease

scientific article published in February 2005
Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.

scientific article
Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques

scientific article published on May 2008
Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina.

scientific article published on May 2003
CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.

scientific article published in April 2006
Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution

scientific article published in April 2009

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