List of works - Paolo Paganetti

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

scientific article published on 28 November 2011

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

scientific article

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

scientific article published in May 2000

Atg4b-dependent autophagic flux alleviates Huntington's disease progression

scientific article

BACE (beta-secretase) modulates the processing of APLP2 in vivo

scientific article

BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease

scientific article published on 13 October 2015

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice

scientific article published in January 2007

Consequences of individual N-glycan deletions and of proteasomal inhibition on secretion of active BACE.

scientific article published on 16 July 2008

Corrigendum to "Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization"

scientific article published on 09 March 2020

Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay

scientific article

Development of a method for the high-throughput quantification of cellular proteins

scientific article

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

scientific article

Distinct Processing of Endogenous and Overexpressed Recombinant Presenilin 1 ⬇️

scientific article published on March 1, 1997

EDEM contributes to maintenance of protein folding efficiency and secretory capacity.

scientific article

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

scientific article published on 12 September 2006

ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport

scientific article published on 03 August 2018

Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.

scientific article published on April 1996

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer

scientific article published on 16 November 2020

Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats

scientific article published on 9 April 2016

Epithelial growth factor receptor expression influences 5-ALA induced glioblastoma fluorescence

scientific article published on 12 May 2017

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

scientific article

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

scientific article

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

scientific article

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models

scientific article published on 2 October 2017

Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease

scientific article (publication date: 2011)

Heterogeneous distribution of calmodulin- and cAMP-dependent regulation of Ca2+ uptake in cardiac sarcoplasmic reticulum subfractions

scientific article published on 01 October 1988

Human genome-guided identification of memory-modulating drugs

scientific article (publication date: 21 October 2013)

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

scientific article published on 14 December 2010

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

scientific article published on January 2010

Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis.

scientific article published in January 2014

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model.

scientific article

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

scientific article published on November 1995

Lack of beta-amyloid production in M19 cells deficient in site 2 processing of the sterol regulatory element binding proteins.

scientific article published on May 1998

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

scientific article

Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count.

scientific article published on 4 December 2010

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

scientific article published on 19 October 2017

Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouse.

scientific article

Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease

scientific article

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1

scientific article

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways

scientific article published in Scientific Reports

Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease

scientific article

Proteolytic processing of the Aplysia A peptide precursor in AtT-20 cells.

scientific article published on January 1994

Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization

scientific article published on 16 October 2019

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice

scientific article published on 31 March 2010

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

scientific article

Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER.

scientific article

Splicing of intron 3 of human BACE requires the flanking introns 2 and 4.

scientific article published on 12 August 2009

Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins

scientific article published on 25 October 2017

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors

scientific article

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

scientific article published on 6 March 2012

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation.

scientific article published on 13 May 2016

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

scientific article

Tau affects P53 function and cell fate during the DNA damage response

scientific article published on 19 May 2020

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

scientific article published on 01 November 1996

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

scientific article

Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase.

scientific article published in September 2004

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

scientific article

beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide.

scientific article

List of works by Paolo Paganetti

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

Atg4b-dependent autophagic flux alleviates Huntington's disease progression

BACE (beta-secretase) modulates the processing of APLP2 in vivo

BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice

Consequences of individual N-glycan deletions and of proteasomal inhibition on secretion of active BACE.

Corrigendum to "Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization"

Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay

Development of a method for the high-throughput quantification of cellular proteins

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

Distinct Processing of Endogenous and Overexpressed Recombinant Presenilin 1 ⬇️

EDEM contributes to maintenance of protein folding efficiency and secretory capacity.

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport

Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer

Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats

Epithelial growth factor receptor expression influences 5-ALA induced glioblastoma fluorescence

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models

Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease

Heterogeneous distribution of calmodulin- and cAMP-dependent regulation of Ca2+ uptake in cardiac sarcoplasmic reticulum subfractions

Human genome-guided identification of memory-modulating drugs

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis.

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model.

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

Lack of beta-amyloid production in M19 cells deficient in site 2 processing of the sterol regulatory element binding proteins.

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count.

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouse.

Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways

Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease

Proteolytic processing of the Aplysia A peptide precursor in AtT-20 cells.

Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER.

Splicing of intron 3 of human BACE requires the flanking introns 2 and 4.

Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation.

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

Tau affects P53 function and cell fate during the DNA damage response

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase.

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide.