Search filters

List of works by Birgit Sawitzki

Abdominal Wall Transplantation: Skin as a Sentinel Marker for Rejection

scientific article published on 29 December 2015

Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol

scientific article published on 3 May 2016

Allo-specific T-cells encoding for viral IL-10 exert strong immunomodulatory effects in vitro but fail to prevent graft rejection

scientific article published in February 2005

Allogeneic Liver Transplantation and Subsequent Syngeneic Hepatocyte Transplantation in a Rat Model: Proof of Concept for in vivo Tissue Engineering

scientific article published on 20 May 2016

Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study

scientific article published on 11 November 2010

Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer: a clinical phase I/II study

scientific article published on 04 March 2013

Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection

scientific article published on June 2008

Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi.

scientific article

Application of cultured human regulatory T cells requires preclinical in vivo evaluation

scientific article published in March 2012

Autoimmunity and transplantation: a meeting at the crossroads in Berlin

scientific article published in May 2008

B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients.

scientific article published in January 2013

Bag-1 up-regulation in anti-CD4 mAb-treated allo-activated T cell confers resistance to activation-induced cell death (AICD).

scientific article

CD30 discriminates heat shock protein 60-induced FOXP3+ CD4+ T cells with a regulatory phenotype.

scientific article

CD45RA distinguishes CD4+CD25+CD127-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus mediated inhibition of suppression.

scientific article

Can we use biomarkers and functional assays to implement personalized therapies in transplantation?

scientific article published on June 2009

Cellular energy metabolism in T-lymphocytes

scientific article published on 26 September 2014

Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance

scientific article published on 2 January 2015

Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort

scientific article

Clinical relevance of the de novo production of anti-HLA antibodies following intestinal and multivisceral transplantation

scientific article published on 16 January 2014

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

scientific article published on 28 December 2021

Control of TNF-induced dendritic cell maturation by hybrid-type N-glycans

scientific article

Correction: Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-γ Producing Helper T Cells

scientific article published on 24 November 2015

Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

scientific article published on 29 July 2011

Demethylation of the TSDR is a marker of squamous cell carcinoma in transplant recipients

scientific article published on 23 September 2014

Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells

scientific article

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

scientific article

Dextran Sulfate Facilitates Anti-CD4 mAb-Induced Long-Term Rat Cardiac Allograft Survival After Prolonged Cold Ischemia

Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-γ Producing Helper T Cells

scientific article published on 14 July 2015

Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells

scientific article published in June 2011

Early Enrichment and Restitution of the Peripheral Blood Treg Pool Is Associated With Rejection-Free Stable Immunosuppression After Liver Transplantation

scientific article published in July 2016

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

scientific article published on 19 August 2015

Effector T cell subclasses associate with tumor burden in neurofibromatosis type 1 patients

scientific article published on 23 July 2016

Elevation of CD4+ differentiated memory T cells is associated with acute cellular and antibody-mediated rejection after liver transplantation

scientific article

Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

scientific article published on November 2016

Ex vivo gene transfer of viral interleukin-10 to BB rat islets: no protection after transplantation to diabetic BB rats

scientific article published on July 2007

Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection

scientific article published in May 2008

Expansion of memory-type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and rapamycin.

scientific article published on August 2013

Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney

article

Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies

scientific journal article

Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies

scientific article published on 01 October 2002

Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus

scientific article

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

scientific article published on 9 August 2011

Generation of HCMV-specific T-cell lines from seropositive solid-organ-transplant recipients for adoptive T-cell therapy

scientific article published on November 2009

Generation of highly effective and stable murine alloreactive Treg cells by combined anti-CD4 mAb, TGF-β, and RA treatment.

scientific article published on 9 September 2013

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

High weight differences between donor and recipient affect early kidney graft function--a role for enhanced IL-6 signaling.

scientific article published on 26 June 2009

Human CD45RA(-) FoxP3(hi) Memory-Type Regulatory T Cells Show Distinct TCR Repertoires With Conventional T Cells and Play an Important Role in Controlling Early Immune Activation.

scientific article published on 18 May 2015

Hurdles in therapy with regulatory T cells

scientific article published on September 2015

IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

scientific article published on June 2005

IFN-gamma regulation in anti-CD4 antibody-induced T cell unresponsiveness

scientific article published in March 2004

IRF1 and BATF-transcription factors that set the epigenetic landscape for Tr1 cell differentiation?

scientific article published on 10 July 2017

Identification of gene markers for the prediction of allograft rejection or permanent acceptance.

scientific article

Immune monitoring as prerequisite for transplantation tolerance trials

scientific article

Immune monitoring in renal transplantation: The search for biomarkers

scientific article published on 10 November 2016

Impact of hepatic rearterialization on reperfusion injury and outcome after mouse liver transplantation

scientific article published in July 2003

Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing.

scientific article

Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival

scientific article published on 24 June 2010

Interferon Gamma: Friend or Foe?

Interferon γ: a crucial role in the function of induced regulatory T cells in vivo

Intragraft and Systemic Immune Parameters Discriminating Between Rejection and Long-Term Graft Function in a Preclinical Model of Intestinal Transplantation

scientific article published on 8 September 2016

Intragraft mechanisms associated with the immunosuppressive versus the tolerogenic effect of CD3 antibodies in a mouse model of islet allografts.

scientific article

Isolation, characterization and cold storage of cells isolated from diseased explanted livers

scientific article published on 23 May 2017

Liver Transplant Patients With Operational Tolerance: What Can the Graft Itself Tell Us?

scientific article published on 25 November 2015

Low-dose cyclosporine mediates donor hyporesponsiveness in a fully mismatched rat kidney transplant model

scientific article published on 4 March 2012

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

scientific article published on 31 August 2015

Mechanisms and rescue strategies of calcineurin inhibitor mediated tolerance abrogation induced by anti-CD4 mAb treatment.

scientific article published on 15 July 2013

Microglial activation milieu controls regulatory T cell responses.

scientific article published on 21 October 2013

Molecular Analysis of Renal Allograft Biopsies-More Than a Nice Toy for Researchers?

scientific article published on 01 March 2013

Molecular Characterization of Acute Cellular Rejection Occurring During Intentional Immunosuppression Withdrawal in Liver Transplantation.

scientific article published on 30 October 2015

Monitoring tolerance and rejection in organ transplant recipients.

scientific article published on July 2011

No prolongation of skin allograft survival by immunoproteasome inhibition in mice.

scientific article published on 2 June 2017

Non-HLA Antibodies May Accelerate Immune Responses After Intestinal and Multivisceral Transplantation

scientific article published on 5 August 2016

Peripheral biomarkers for individualizing immunosuppression in transplantation--regulatory T cells

scientific article published on 18 February 2012

Permanent CNI treatment for prevention of renal allograft rejection in sensitized hosts can be replaced by regulatory T cells

scientific article

Pretransplant immune risk assessment.

scientific article published on December 2009

Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood Toll-like receptor 5 mRNA expression

scientific article published on November 2013

Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation.

scientific article published on 19 June 2013

Rat Cytomegalovirus Infection Interferes with Anti-CD4 mAb-(RIB 5/2) Mediated Tolerance and Induces Chronic Allograft Damage

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

scientific article

Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial.

scientific article

Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors

scientific article

Short-term TNF-alpha inhibition reduces short-term and long-term inflammatory changes post-ischemia/reperfusion in rat intestinal transplantation

scientific journal article

Standardized Multi-Color Flow Cytometry and Computational Biomarker Discovery

scientific article published on January 2016

State of the art on the research for biomarkers allowing individual, tailor-made minimization of immunosuppression

scientific article published on December 2010

Synovial and peripheral blood CD4+FoxP3+ T cells in spondyloarthritis

scientific article published on 15 September 2011

TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production

scientific article

TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance

scientific article published on 29 January 2016

Targeting of macrophage activity by adenovirus-mediated intragraft overexpression of TNFRp55-Ig, IL-12p40, and vIL-10 ameliorates adenovirus-mediated chronic graft injury, whereas stimulation of macrophages by overexpression of IFN-gamma accelerates

scientific article published in January 2003

The mitochondrial protein TCAIM regulates activation of T cells and thereby promotes tolerance induction of allogeneic transplants

scientific article published on 31 October 2014

The use of novel diagnostics to individualize immunosuppression following transplantation

scientific article

Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion

scientific article published on 8 November 2006

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

scientific article published on 08 November 2021

Tregs: application for solid-organ transplantation

scientific article published on February 2012

Upregulation of Bag-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury

scientific article published in August 2002

Wild immunology assessed by multidimensional mass cytometry.

scientific article published on 12 July 2016

Paulina is supported by:

About Paulina

Help