List of works - Sami Heikkinen

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

scientific article published on 01 November 2019

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

scientific article published on 3 December 2009

Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb.

scientific article published on January 2004

Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging

scientific article published on 21 December 2019

Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression

scientific article

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia

scientific article published in June 1997

Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice

scientific article

Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia

scientific article published in November 1998

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis

scientific article published on 28 April 2011

Dynamics of 1α,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes

scientific article published on November 2013

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

scientific article

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.

scientific article

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns

scientific article published in July 1998

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

scientific article published on 09 December 2019

Histopathology in mouse metabolic investigations

scientific article published on 01 April 2007

ImatraNMR: Novel software for batch integration and analysis of quantitative NMR spectra ⬇️

scientific article published on June 25, 2011

In Vitro Studies on Stability of L-p-boronophenylalanine–fructose Complex (BPA-F) ⬇️

scientific article published on April 23, 2011

Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes.

scientific article

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

scientific article published on 23 February 2021

MicroRNAs Associated With Biological Pathways of Left- and Right-sided Colorectal Cancer

scientific article published on 01 July 2020

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

scientific article published on 12 November 2019

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland

article

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

scientific article

New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.

scientific article

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy

scientific article published on 16 August 2011

Patterns of genome-wide VDR locations.

scientific article

Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns

scientific article published in January 1997

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors

scientific article published on 06 November 2012

Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury

scientific article

SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner.

scientific article

Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns

scientific article published in March 1998

Systematic gene expression mapping clusters nuclear receptors according to their function in the brain.

scientific article published in October 2007

The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Does Not Influence Insulin Sensitivity in Finnish Nondiabetic and NIDDM Subjects

article

The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.

scientific article published on 9 January 2018

The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs

scientific article

The Trp64Arg Polymorphism of the 3-Adrenergic Receptor Gene: Lack of association with NIDDM and features of insulin resistance syndrome

article

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

scientific article

The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients

scientific article published on 01 July 1999

The down-regulation of the human MYC gene by the nuclear hormone 1alpha,25-dihydroxyvitamin D3 is associated with cycling of corepressors and histone deacetylases.

scientific article published on 21 May 2010

The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.

scientific article

The first genome-wide view of vitamin D receptor locations and their mechanistic implications.

scientific article published on January 2012

The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor

scientific article published on 7 December 2012

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells

scientific article

The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D.

scientific article

Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects

scientific article published on 01 May 1997

Transgenic mice expressing the human ornithine decarboxylase gene under the control of mouse metallothionein I promoter.

scientific article published on March 1996

Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines

scientific article published on February 2007

Variants in the Human Intestinal Fatty Acid Binding Protein 2 Gene in Obese Subjects ⬇️

scientific article published on August 1, 1997

Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM.

scientific article published in May 1998

List of works by Sami Heikkinen

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb.

Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging

Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia

Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice

Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis

Dynamics of 1α,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Histopathology in mouse metabolic investigations

ImatraNMR: Novel software for batch integration and analysis of quantitative NMR spectra ⬇️

In Vitro Studies on Stability of L-p-boronophenylalanine–fructose Complex (BPA-F) ⬇️

Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes.

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

MicroRNAs Associated With Biological Pathways of Left- and Right-sided Colorectal Cancer

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy

Patterns of genome-wide VDR locations.

Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors

Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury

SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner.

Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns

Systematic gene expression mapping clusters nuclear receptors according to their function in the brain.

The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Does Not Influence Insulin Sensitivity in Finnish Nondiabetic and NIDDM Subjects

The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.

The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs

The Trp64Arg Polymorphism of the 3-Adrenergic Receptor Gene: Lack of association with NIDDM and features of insulin resistance syndrome

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients

The down-regulation of the human MYC gene by the nuclear hormone 1alpha,25-dihydroxyvitamin D3 is associated with cycling of corepressors and histone deacetylases.

The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.

The first genome-wide view of vitamin D receptor locations and their mechanistic implications.

The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells

The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D.

Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects

Transgenic mice expressing the human ornithine decarboxylase gene under the control of mouse metallothionein I promoter.

Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines

Variants in the Human Intestinal Fatty Acid Binding Protein 2 Gene in Obese Subjects ⬇️

Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM.