List of works - Stefania Villa

3,8-diazabicyclo--[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent.

scientific article published in June 2001

A field-based disparity analysis of new 1,2,5-oxadiazole derivatives endowed with antiproliferative activity

scientific article

An Exhaustive Conformational Evaluation of the HIV-1 Inhibitor BMS-378806 through Theoretical Calculations and Nuclear Magnetic Resonance Spectroscopy

article

An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis

scientific article published on 01 January 2019

An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties

scientific article published on 15 March 2017

Benzocondensed derivatives as rigid analogues of the mu-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3.2.1]octanes: synthesis, modeling, and affinity.

scientific article

Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors

article published in 2012

Complete Characterization of the 3D Properties of the CCR5 Antagonist Vicriviroc through DFT Calculations, NMR Spectroscopy, and X-ray Analysis

Congo red analogues as potential anti-prion agents

scientific article published in September 2003

Crystal structure of 3-(3-oxo-2,3,4,4a,5,6-hexa-hydro-benzo[h]cinnolin-2-yl)propionic acid

scientific article published on 6 September 2014

Diazabicyclo analogues of maraviroc: synthesis, modeling, NMR studies and antiviral activity

scientific article published on 16 December 2016

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

scientific article published on 18 June 2018

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines

scientific article published on 24 July 2019

Exploring the Biological Activity of a Library of 1,2,5-Oxadiazole Derivatives Endowed With Antiproliferative Activity

scientific article published on 01 January 2019

Iron Acquisition Pathways as Targets for Antitubercular Drugs

scientific article

Low density polyethylene functionalized with antibiofilm compounds inhibits Escherichia coli cell adhesion

scientific article

Modeling and Spectroscopic Studies of Synthetic Diazabicyclo Analogs of the HIV-1 Inhibitor BMS-378806 and Evaluation of Their Antiviral Activity

article

Modeling, synthesis and NMR characterization of novel chimera compounds targeting STAT3

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling

scientific article published in February 1998

Monocyclic analogues of the μ-opioid agonist 3,8-diazabicyclo [3.2.1]octanes: Synthesis, modeling, and activity

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

scientific article published on 21 June 2018

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

scientific article published on 01 December 2019

Novel peptidomimetics related to gonadotropin-releasing hormone (GnRH)

Pharmacokinetics and distribution of sodium 3,4-diaminonaphthalene-1-sulfonate, a Congo Red derivative active in inhibiting PrP(res) replication.

scientific article published in March 2004

Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy

scientific article published on April 2011

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors.

scientific article published on 30 January 2018

Sub-lethal activity of small molecules from natural sources and their synthetic derivatives against biofilm forming nosocomial pathogens

scientific article

Synthesis and mu-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives.

scientific article

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

scientific article

Synthesis of a new series of 2,7-diazaspiro[3.5]nonan-1-ones and study of their cholinergic properties

Synthesis of a new series of 2,8-disubstituted-2,8-diazaspiro[4,5]decan-1-ones as potential muscarinic agonists

Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3' allyl end and at the phenyl ring of the cinnamyl chain on mu-receptor affinity and opioid antinociception

scientific article

Synthesis, modeling, and crystallographic study of 3,4-disubstituted-1,2,5-oxadiazoles and evaluation of their ability to decrease STAT3 activity

article published in 2010

Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety

scientific article published on June 2009

Synthesis, modelling, and mu-opioid receptor affinity of N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicycl

scientific article

Synthesis, structure–activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors

The influence of the substitution pattern on the molecular conformation of ureido-1,2,5-oxadiazoles, related to STAT3 inhibitors: chemical behavior and structural investigation

scientific article

The response of Escherichia coli biofilm to salicylic acid

scientific article published on 20 February 2017

Towards the Inhibition of Protein-Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives

scientific article published on 31 July 2020

Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity

Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives

scientific article published on 01 July 2019

Unravelling the Structural and Molecular Basis Responsible for the Anti-Biofilm Activity of Zosteric Acid

scientific article

Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition

Zosteric acid and salicylic acid bound to a low density polyethylene surface successfully control bacterial biofilm formation.

scientific article

List of works by Stefania Villa

3,8-diazabicyclo--[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent.

A field-based disparity analysis of new 1,2,5-oxadiazole derivatives endowed with antiproliferative activity

An Exhaustive Conformational Evaluation of the HIV-1 Inhibitor BMS-378806 through Theoretical Calculations and Nuclear Magnetic Resonance Spectroscopy

An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis

An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties

Benzocondensed derivatives as rigid analogues of the mu-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3.2.1]octanes: synthesis, modeling, and affinity.

Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors

Complete Characterization of the 3D Properties of the CCR5 Antagonist Vicriviroc through DFT Calculations, NMR Spectroscopy, and X-ray Analysis

Congo red analogues as potential anti-prion agents

Crystal structure of 3-(3-oxo-2,3,4,4a,5,6-hexa-hydro-benzo[h]cinnolin-2-yl)propionic acid

Diazabicyclo analogues of maraviroc: synthesis, modeling, NMR studies and antiviral activity

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines

Exploring the Biological Activity of a Library of 1,2,5-Oxadiazole Derivatives Endowed With Antiproliferative Activity

Iron Acquisition Pathways as Targets for Antitubercular Drugs

Low density polyethylene functionalized with antibiofilm compounds inhibits Escherichia coli cell adhesion

Modeling and Spectroscopic Studies of Synthetic Diazabicyclo Analogs of the HIV-1 Inhibitor BMS-378806 and Evaluation of Their Antiviral Activity

Modeling, synthesis and NMR characterization of novel chimera compounds targeting STAT3

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling

Monocyclic analogues of the μ-opioid agonist 3,8-diazabicyclo [3.2.1]octanes: Synthesis, modeling, and activity

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

Novel peptidomimetics related to gonadotropin-releasing hormone (GnRH)

Pharmacokinetics and distribution of sodium 3,4-diaminonaphthalene-1-sulfonate, a Congo Red derivative active in inhibiting PrP(res) replication.

Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors.

Sub-lethal activity of small molecules from natural sources and their synthetic derivatives against biofilm forming nosocomial pathogens

Synthesis and mu-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives.

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

Synthesis of a new series of 2,7-diazaspiro[3.5]nonan-1-ones and study of their cholinergic properties

Synthesis of a new series of 2,8-disubstituted-2,8-diazaspiro[4,5]decan-1-ones as potential muscarinic agonists

Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3' allyl end and at the phenyl ring of the cinnamyl chain on mu-receptor affinity and opioid antinociception

Synthesis, modeling, and crystallographic study of 3,4-disubstituted-1,2,5-oxadiazoles and evaluation of their ability to decrease STAT3 activity

Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety

Synthesis, modelling, and mu-opioid receptor affinity of N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicycl

Synthesis, structure–activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors

The influence of the substitution pattern on the molecular conformation of ureido-1,2,5-oxadiazoles, related to STAT3 inhibitors: chemical behavior and structural investigation

The response of Escherichia coli biofilm to salicylic acid

Towards the Inhibition of Protein-Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives

Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity

Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives

Unravelling the Structural and Molecular Basis Responsible for the Anti-Biofilm Activity of Zosteric Acid

Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition

Zosteric acid and salicylic acid bound to a low density polyethylene surface successfully control bacterial biofilm formation.