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List of works by Lynne S Cox

A fluorescence-based exonuclease assay to characterize DmWRNexo, orthologue of human progeroid WRN exonuclease, and its application to other nucleases

scientific article published on 23 December 2013

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

scientific article

Animal and human models to understand ageing.

scientific article

Asymmetry of DNA replication fork progression in Werner's syndrome

scientific article

Cell senescence: the future of ageing?

scientific article published on 30 December 2008

Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum.

scientific article published in March 2003

Characterisation of the interaction between PCNA and Gadd45

scientific article

Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

scientific article

DNA replication in cell-free extracts from Xenopus eggs is prevented by disrupting nuclear envelope function

scientific article published on January 1, 1992

DNA replication occurs at discrete sites in pseudonuclei assembled from purified DNA in vitro.

scientific article published in July 1991

Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

scientific article published on February 2004

DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease

scientific article published on 28 October 2008

EDITORIAL. REGULATION OF APOPTOSIS BY Bcl-2 AND ITS RELATED PROTEINS: IMMUNOCHEMICAL CHALLENGES AND THERAPEUTIC IMPLICATIONS

scientific article published on 01 May 1996

From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

scientific article published on October 2007

Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins

scientific article published on 21 January 2019

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity

scientific article published on 11 March 2008

Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium falciparum.

scientific article published on December 2002

Intercellular Transfer of Mitochondria between Senescent Cells through Cytoskeleton-Supported Intercellular Bridges Requires mTOR and CDC42 Signalling

scientific article published on 31 July 2021

Live fast, die young: new lessons in mammalian longevity.

scientific article published in August 2009

MDM2 and MDMX bind and stabilize the p53-related protein p73

scientific article

Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease

scientific article published in November 2007

Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1 ⬇️

scientific article published on October 1, 1997

Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

scientific article published on 11 February 2019

PCNA tightens its hold on the nucleus.

scientific article published on 15 July 2015

Prospects for rejuvenation of aged tissue by telomerase reactivation.

scientific article published on December 2010

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

scientific article (publication date: February 2012)

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.

scientific article published on 5 February 2016

Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

scientific article published on April 2000

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence.

scientific article published on 17 October 2017

Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress

scientific article published on 10 August 2020

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.

scientific article published on 23 September 2015

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro

scientific article

The role of DNA exonucleases in protecting genome stability and their impact on ageing.

scientific article

The role of cellular senescence in ageing of the placenta

scientific article published on 16 January 2017

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

scientific article

Two Pathways for Base Excision Repair in Mammalian Cells

scientific article published in Journal of Biological Chemistry

Who binds wins: Competition for PCNA rings out cell-cycle changes

article

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

scholarly article by Hannah E Walters published in August 2018

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