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List of works by Tongqing Zhou

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article (publication date: 2015)

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

scientific article published on 7 March 2018

A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation

scientific article published on 01 May 2019

A Versatile Platform to Incorporate Viral Trimeric Antigens into Self-Assembling Nanoparticle Immunogens

scientific article published on 12 June 2020

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

scientific article published on 26 January 2022

A kinetic model for the action of a resistance efflux pump.

scientific article

A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike

scientific article published on 04 July 2020

A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone

scientific article published on 23 October 2020

Activation and lysis of human CD4 cells latently infected with HIV-1

scientific article

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

scientific article published on 01 July 2019

Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2

scientific article published on 10 March 2022

Asp45 is a Mg2+ ligand in the ArsA ATPase

scientific article

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

scientific article published on 10 April 2019

Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains

scientific article published on 01 November 2020

Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies

scientific article published on 13 June 2019

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers.

scientific article published in October 2014

Characteristics of HIV-1 gp120 molecules that bind ancestor, intermediate and mature forms of VRC01-like antibodies

article

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

scientific article

Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation

scientific article published on 6 June 2001

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies

scientific article

Correction: HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

article

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 02 December 2019

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article published on 24 May 2016

Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

scientific article published on 01 June 2017

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

scientific article published on 17 November 2020

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

scientific article

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

scientific article

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts

scientific article published on 08 October 2013

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

scientific article

Design clues from functional constraints and broadly neutralizing antibodies

Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site.

scientific article

Eliminating antibody polyreactivity through addition of N-linked glycosylation

scientific article published on 12 May 2015

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

scientific article published on 04 March 2009

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

scientific article

Enhancing protein crystallization through precipitant synergy

scientific article

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Evaluation of candidate vaccine approaches for MERS-CoV.

scientific article published on 28 July 2015

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

scientific article published on 28 July 2020

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

scientific article

Free Energy Perturbation Calculation of Relative Binding Free Energy between Broadly Neutralizing Antibodies and the gp120 Glycoprotein of HIV-1.

scientific article

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

HIV-1 Envelope Glycan Modifications that Permit Neutralization by Germline-Reverted VRC01-Class Broadly Neutralizing Antibodies

article

High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

scientific article published on 08 April 2021

Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation

scientific article published on 01 September 2020

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

scientific article published on November 2016

Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature

scientific article published on 01 August 2020

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

scientific article published on 7 March 2018

Interfacial metal and antibody recognition

scientific article

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody.

scientific article

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

scientific article published on 29 October 2021

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

scientific article

Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment

scientific article published on 19 August 2009

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

scientific article

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 17 September 2019

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

scientific article

Nonequivalence of the nucleotide binding domains of the ArsA ATPase.

scientific article published on 6 January 2005

Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04

scientific article

P09-05. Mechanism of HIV-1 resistance to a monoclonal antibody that effectively targets the site of CD4 attachment

article

P09-13. Structure of HIV-1 gp41 interactive region: layered architecture and basis of conformational mobility

article

PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.

scientific article published on 15 February 2012

Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer

scientific article published on 06 June 2016

Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike

scientific article published on 18 June 2020

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

scientific article published on 22 July 2020

Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen

scientific article published on 20 February 2020

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

scientific article published on 01 April 2019

Protection of calves by a prefusion-stabilized bovine RSV F vaccine

scientific article published on March 2017

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

scientific article published on 20 February 2017

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

scientific article (publication date: 13 August 2010)

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

scientific article published on 13 September 2020

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies

scientific article published on 01 January 2020

Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

scientific article published on 10 July 2013

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

scientific article

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

scientific article published in December 2017

Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies

scientific article

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

scientific article

Spatiotemporal hierarchy in antibody recognition against transmitted HIV-1 envelope glycoprotein during natural infection

scientific article published on 17 February 2016

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

scientific article

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

scientific article

Structural Features of Broadly Neutralizing Antibodies and Rational Design of Vaccine

scientific article published on 01 January 2018

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

scientific article

Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

article

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

scientific article published on 09 July 2021

Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies

scientific article published on 01 November 2021

Structural definition for a new modality of broad and potent antibody neutralization at the CD4-binding site on HIV-1 gp120.

scientific article published on 13 September 2012

Structural definition of a conserved neutralization epitope on HIV-1 gp120

scientific article

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

scientific article

Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer.

scientific article published in October 2014

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

scientific article

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

scientific article

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

scientific article published on 8 March 2017

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

scientific article published on 23 June 2020

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

scientific article published on 21 July 2020

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes ⬇️

scientific article published on 12 October 2020

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structure-based design of head-only fusion glycoprotein immunogens for respiratory syncytial virus

scientific article

Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site

scientific article (publication date: May 2009)

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

scientific article

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

scientific article

Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles

scientific article published on 29 June 2020

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article

Transient Protein Expression Facilitates X-ray Structural Studies of HIV-1.

scientific article

Transplanting supersites of HIV-1 vulnerability

scientific article

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

scientific article

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

scientific article

Tryptophan fluorescence reports nucleotide-induced conformational changes in a domain of the ArsA ATPase.

scientific article published in August 1997

Unisite and multisite catalysis in the ArsA ATPase.

scientific article published on 18 April 2002

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

scientific article

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage

scientific article published on 03 March 2020

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