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List of works by Irina Vetter

2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin

scientific article published on 24 June 2014

32. Development of High Throughput Calcium Channel Assays to Accelerate the Discovery of Novel Toxins Targeting Human Cav2.2 Channels

scholarly article by Silmara R. Sousa et al published August 2012 in Toxicon

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins ⬇️

scientific article

A comprehensive portrait of the venom of the giant red bull ant, , reveals a hyperdiverse hymenopteran toxin gene family

article

A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii).

scientific article

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

scientific article

Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia

scientific article published on 30 July 2015

Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7.

scientific article published on 19 February 2020

Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition

scientific article published on 01 October 2013

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca 2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay

scientific article published on 09 May 2018

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

scientific article published on 24 May 2013

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

scientific article published on 17 March 2016

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin.

scientific article published on 8 April 2014

Analgesic treatment of ciguatoxin-induced cold allodynia.

scientific article published on 15 June 2013

Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels

scientific article published on 26 February 2018

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

scientific article published on 21 September 2020

Axon guidance by growth-rate modulation.

scientific article

Bayesian model predicts the response of axons to molecular gradients

scientific article

Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment.

scientific article published on 23 September 2017

Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells

scientific article

Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe

scientific article published on 11 June 2020

Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica.

scientific article

Characterization of endogenous calcium responses in neuronal cell lines

scientific article published on 31 October 2009

Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1

scientific article

Chemical synthesis and structure of the prokineticin Bv8

scientific article

Chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor

article

Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries

scientific article

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

scientific article

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.

scientific article published on 31 August 2015

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity

scientific article published on 5 October 2017

Conus Venom Peptide Pharmacology ⬇️

scientific article published on March 8, 2012

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.

scientific article published on 18 July 2016

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands

scientific article published on 8 December 2014

Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs ⬇️

scientific article published on January 1, 2012

Development of a high-throughput fluorescent no-wash sodium influx assay

article

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

scientific article published on 29 March 2016

Differential evolution and neofunctionalization of snake venom metalloprotease domains

scientific article published on 12 December 2012

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

scientific article published on 7 September 2017

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor

scientific article published on 02 October 2020

Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay.

scientific article published on 7 November 2016

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

scientific article

Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells

scientific article

Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231

scientific article

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens

scientific article

Imported tropical fish causes ciguatera fish poisoning in Germany

scientific article published on 22 January 2015

Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives

scientific article

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

scientific article published on 16 June 2016

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

scientific article published on 4 August 2013

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

scientific article

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

scientific article published on 16 May 2012

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors

scientific article published on 08 April 2017

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.

scientific article published on 05 March 2020

Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol

scientific article published on 7 September 2007

Missiles of Mass Disruption: Composition and Glandular Origin of Venom Used as a Projectile Defensive Weapon by the Assassin Bug Platymeris rhadamanthus

scientific article published on 18 November 2019

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

scientific article

MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors

scientific article published on 30 December 2013

Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

scientific article

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

scientific article

NaV1.7 as a pain target - From gene to pharmacology.

scientific article published on December 2016

Natural Product Ligands of TRP Channels ⬇️

scientific article published on January 1, 2011

Neuronal cell lines as model dorsal root ganglion neurons: A transcriptomic comparison

scientific article published on 29 April 2016

Neurotoxic peptides from the venom of the giant Australian stinging tree

scientific article published on 16 September 2020

New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives.

scientific article published on November 2016

No gain, no pain: NaV1.7 as an analgesic target

scientific article

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

scientific article published in Scientific Reports

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

scientific article published on 24 April 2019

Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological, Immunohistochemical and Pharmacological Methods

scientific article

Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology

scientific article published on 27 December 2017

Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy.

scientific article

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

scientific article

Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors

scientific article

Pharmacological screening technologies for venom peptide discovery

scientific article

Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay

scientific article

Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization

scientific article published on 15 May 2008

Release of neuropeptides from a neuro-cutaneous co-culture model: A novel in vitro model for studying sensory effects of ciguatoxins

scientific article published on 10 November 2015

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain.

scientific article published on 21 December 2017

Role of the NLRP3 inflammasome in a model of acute burn-induced pain

scientific article

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

scientific article published in Nature Communications

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach

scientific article published on 4 March 2015

Sodium Channels and Venom Peptide Pharmacology.

scientific article

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

scientific article

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.

scientific article

The Effects of pH on Beta-Endorphin and Morphine Inhibition of Calcium Transients in Dorsal Root Ganglion Neurons

scientific article published on 01 July 2006

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes

scientific article

The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)

scientific article

The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain.

scientific article

The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats

scientific article

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states

scientific article

The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway

scientific article (publication date: 16 July 2006)

The pharmacology of voltage-gated sodium channel activators.

scientific article

The response of dorsal root ganglion axons to nerve growth factor gradients depends on spinal level

scientific article published in August 2010

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

scientific article

The thermal probe test: A novel behavioral assay to quantify thermal paw withdrawal thresholds in mice

scientific article

Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides) ⬇️

scientific article published on January 1, 2012

Therapeutic opportunities for targeting cold pain pathways

scientific article

Toxins in Neurobiology: New tools from old molecules

scientific article published on 05 May 2018

Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom.

scientific article published on 28 October 2015

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target

scientific article published on 28 August 2016

Transcriptomics in pain research: insights from new and old technologies

Venom peptides as a rich source of cav2.2 channel blockers

scientific article published on 4 February 2013

Venomics: a new paradigm for natural products-based drug discovery.

scientific article published on 24 February 2010

Voltage-Gated Sodium Channels as Therapeutic Targets

Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2.

scientific article

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities

scientific article published on 17 May 2017

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

scientific article published on 15 September 2011

α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors.

scientific article

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors.

scientific article

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

scientific article (publication date: 22 July 2015)

ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels

scientific article

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