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List of works by Alexander C Drohat

3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member

scientific article

Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo

scientific article published on 25 February 2016

Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1.

scientific article

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

scientific article published on 24 October 2013

Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA ⬇️

scientific article published on May 2, 2012

Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition

scientific article

Defining the Role of Nucleotide Flipping in Enzyme Specificity Using 19F NMR

scientific article published on 14 March 2019

Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase.

scientific article

Dependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairs

scientific article (publication date: 5 May 2011)

Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.

scientific article published on 07 October 2013

E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex

scientific article

Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2.

scientific article

Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase

scientific article published on 18 November 2019

Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.

scientific article

Functional assessment of population and tumor-associated APE1 protein variants

scientific article

How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA.

scientific article published on 23 August 2012

Kinetic Methods for Studying DNA Glycosylases Functioning in Base Excision Repair.

scientific article published on 26 April 2017

Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA

scientific article

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.

scientific article

Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.

scientific article

NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.

scientific article published on 9 November 2011

Nucleosomes and the three glycosylases: High, medium, and low levels of excision by the uracil DNA glycosylase superfamily

scientific article published on 20 September 2018

Oligomerization state of S100B at nanomolar concentration determined by large‐zone analytical gel filtration chromatography ⬇️

scientific article published on July 1, 1997

Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis.

scientific article

Raman spectroscopy of uracil DNA glycosylase-DNA complexes: insights into DNA damage recognition and catalysis

scientific article published on 01 October 2000

Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

scientific article published on 27 September 2016

Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA

scientific article

Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites

scientific article

Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase.

scientific article

S100B(ββ) inhibits the protein kinase C‐dependent phosphorylation of a peptide derived from p53 in a Ca2+‐dependent manner ⬇️

scientific article published on March 1, 1998

Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy,

scientific article

Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy

scientific article

Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA

scientific article

Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase

scientific article

Structural changes in the C-terminus of Ca2+-bound rat S100B (beta beta) upon binding to a peptide derived from the C-terminal regulatory domain of p53.

scientific article

Structural studies of RNA/DNA polypurine tracts.

scientific article published on March 2008

Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+cofactor

scientific article

The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53

scientific article published on 01 February 1998

The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase

scientific article

The role of cysteine residues in S100B dimerization and regulation of target protein activity

scientific article published on 01 November 1997

Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA

scientific article

Uracil DNA glycosylase: insights from a master catalyst.

scientific article

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