List of works - Karin J Metzner

A Comprehensive Analysis of Primer IDs to Study Heterogeneous HIV-1 Populations

scientific article published on 19 December 2015

A Follow-Up of the Multicenter Collaborative Study on HIV-1 Drug Resistance and Tropism Testing Using 454 Ultra Deep Pyrosequencing

scientific article

A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected Patients

scientific article

A framework for inferring fitness landscapes of patient-derived viruses using quasispecies theory

scientific article

A suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replication

scientific article

A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Deltanef increases viral replication

scientific article

An international multicenter study on HIV-1 drug resistance testing by 454 ultra-deep pyrosequencing

scientific article published on 13 April 2014

Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency

scientific article

Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

scientific article (publication date: 2012)

Changing Trends in International Versus Domestic HCV Transmission in HIV-Positive Men Who Have Sex With Men: A Perspective for the Direct-Acting Antiviral Scale-Up Era

scientific article published on 01 June 2019

Characterization of human immunodeficiency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection

scientific article published on 12 October 2011

Comparison of G-to-A mutation frequencies induced by APOBEC3 proteins in H9 cells and peripheral blood mononuclear cells in the context of impaired processivities of drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants

scientific article published on 30 April 2008

Correction to: Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

scientific article published on 12 October 2017

Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.

scientific article

Detection of minor populations of drug-resistant HIV-1 in acute seroconverters.

scientific article

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

scientific article published on 19 July 2019

EBV renders B cells susceptible to HIV-1 in humanized mice

scientific article published on 23 June 2020

Efficacy and safety of dolutegravir plus emtricitabine versus standard ART for the maintenance of HIV-1 suppression: 48-week results of the factorial, randomized, non-inferiority SIMPL'HIV trial

scientific article published on 10 November 2020

Efficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C virus-coinfected patients.

scientific article published on 4 June 2014

Efficient suppression of minority drug-resistant HIV type 1 (HIV-1) variants present at primary HIV-1 infection by ritonavir-boosted protease inhibitor-containing antiretroviral therapy

scientific article published in April 2010

Emergence of Resistance to Integrase Strand Transfer Inhibitors during Dolutegravir Containing Triple-Therapy in a Treatment-Experienced Patient with Pre-Existing M184V/I Mutation

scientific article published on 19 November 2020

Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions

scientific article published on 3 November 2003

Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus

scientific article

Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations

scientific article

HCV Genetic Diversity Can Be Used to Infer Infection Recency and Time since Infection

scientific article published on 31 October 2020

HIV suppression by interleukin-16.

scientific article published in December 1995

HIV-1 RNAs are Not Part of the Argonaute 2 Associated RNA Interference Pathway in Macrophages

scientific article published on 30 July 2015

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

scientific article published on 02 November 2020

Impact of minority nonnucleoside reverse transcriptase inhibitor resistance mutations on resistance genotype after virologic failure

scientific article published on 21 December 2012

In Vivo and in Vitro Proteome Analysis of Human Immunodeficiency Virus (HIV)-1-infected, Human CD4+ T Cells

scientific article

In-depth analysis of G-to-A hypermutation rate in HIV-1 env DNA induced by endogenous APOBEC3 proteins using massively parallel sequencing

scientific article published on 24 November 2010

Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013.

scientific article published on January 2015

Inhibition of drug-resistant HIV-1 by RNA interference

scientific article

Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients

scientific article published on September 2014

Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history

scientific article published on 28 December 2020

Low prevalence of transmitted HIV-1 drug resistance detected by a dried blood spot (DBS)-based next-generation sequencing (NGS) method in newly diagnosed individuals in Cameroon in the years 2015-16.

scientific article published on 7 April 2018

Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing

scientific article

MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing

scientific article published on 17 November 2016

Mining for pairs: shared clinic visit dates identify steady HIV-positive partnerships.

scientific article published on 4 April 2017

Minority K65R variants and early failure of antiretroviral therapy in HIV-1-infected Eritrean immigrant

scientific article published on October 2011

Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients

scientific article

Molecular characterisation of Lac s 1, the major allergen from lettuce (Lactuca sativa).

scientific article

Molecular cloning, expression and characterization of Pru a 1, the major cherry allergen.

scientific article

Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4(+) T cells

scientific article published on 12 April 2016

Next-generation sequencing of HIV-1 RNA genomes: determination of error rates and minimizing artificial recombination

scientific article

No Effect of Pegylated Interferon-alpha on Total Hiv-1 DNA Load in HIV-1/HCV Coinfected Patients.

scientific article

Noninferiority of Simplified Dolutegravir Monotherapy Compared to Continued Combination Antiretroviral Therapy That Was Initiated During Primary Human Immunodeficiency Virus Infection: A Randomized, Controlled, Multisite, Open-label, Noninferiority

scientific article published on 01 October 2019

Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection

scientific article published on 11 July 2013

Parallel evolution of HIV-1 in a long-term experiment

scientific article published on 28 June 2019

Persistence of drug-resistant HIV-1 and possible implications for antiretroviral therapy

article

Persistence of lamivudine-sensitive HIV-1 quasispecies in the presence of lamivudine in vitro and in vivo.

scientific article published in April 2007

Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naïve patients

scientific article published on 4 November 2010

Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection

scientific article (publication date: 12 October 2010)

Rapid decline of anti-hepatitis C virus (HCV) antibodies following early treatment of incident HCV infections in HIV-infected men who have sex with men.

scientific article

Rapid selection of drug-resistant HIV-1 during the first months of suppressive ART in treatment-naive patients

article

Rational design of HIV-1 fluorescent hydrolysis probes considering phylogenetic variation and probe performance.

scientific article published on 29 January 2010

Reappearance of minority K103N HIV-1 variants after interruption of ART initiated during primary HIV-1 infection

scientific article

Recovering networks from distance data

Reply to correspondence 'Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a "stochastic" process' by Gonzalez et al., Retrovirology 2017.

scientific article published on 24 February 2017

Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine.

scientific article published in January 2000

Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector.

scientific article published on 5 July 2018

Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study

article

Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α.

scientific article

Tailored enrichment strategy detects low abundant small noncoding RNAs in HIV-1 infected cells

scientific article

Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques

scientific article published on 21 December 2006

The antiretroviral potency of emtricitabine is approximately 3-fold higher compared to lamivudine in dual human immunodeficiency virus type 1 infection/competition experiments in vitro

scientific article published on 17 March 2010

Tracing HIV-1 strains that imprint broadly neutralizing antibody responses

scientific article published in Nature

Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs

scientific article published on 05 September 2016

Unravelling HIV-1 Latency, One Cell at a Time

scientific article

Using longitudinally sampled viral nucleotide sequences to characterize the drivers of HIV-1 transmission

scientific article published on 25 December 2020

Viral Diversity Based on Next-Generation Sequencing of HIV-1 Provides Precise Estimates of Infection Recency and Time Since Infection

scientific article published on 01 June 2019

Women in the European Virus Bioinformatics Center

scientific article published on 13 July 2022

List of works by Karin J Metzner

A Comprehensive Analysis of Primer IDs to Study Heterogeneous HIV-1 Populations

A Follow-Up of the Multicenter Collaborative Study on HIV-1 Drug Resistance and Tropism Testing Using 454 Ultra Deep Pyrosequencing

A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected Patients

A framework for inferring fitness landscapes of patient-derived viruses using quasispecies theory

A suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replication

A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Deltanef increases viral replication

An international multicenter study on HIV-1 drug resistance testing by 454 ultra-deep pyrosequencing

Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency

Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

Changing Trends in International Versus Domestic HCV Transmission in HIV-Positive Men Who Have Sex With Men: A Perspective for the Direct-Acting Antiviral Scale-Up Era

Characterization of human immunodeficiency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection

Comparison of G-to-A mutation frequencies induced by APOBEC3 proteins in H9 cells and peripheral blood mononuclear cells in the context of impaired processivities of drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants

Correction to: Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.

Detection of minor populations of drug-resistant HIV-1 in acute seroconverters.

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

EBV renders B cells susceptible to HIV-1 in humanized mice

Efficacy and safety of dolutegravir plus emtricitabine versus standard ART for the maintenance of HIV-1 suppression: 48-week results of the factorial, randomized, non-inferiority SIMPL'HIV trial

Efficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C virus-coinfected patients.

Efficient suppression of minority drug-resistant HIV type 1 (HIV-1) variants present at primary HIV-1 infection by ritonavir-boosted protease inhibitor-containing antiretroviral therapy

Emergence of Resistance to Integrase Strand Transfer Inhibitors during Dolutegravir Containing Triple-Therapy in a Treatment-Experienced Patient with Pre-Existing M184V/I Mutation

Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions

Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus

Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations

HCV Genetic Diversity Can Be Used to Infer Infection Recency and Time since Infection

HIV suppression by interleukin-16.

HIV-1 RNAs are Not Part of the Argonaute 2 Associated RNA Interference Pathway in Macrophages

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Impact of minority nonnucleoside reverse transcriptase inhibitor resistance mutations on resistance genotype after virologic failure

In Vivo and in Vitro Proteome Analysis of Human Immunodeficiency Virus (HIV)-1-infected, Human CD4+ T Cells

In-depth analysis of G-to-A hypermutation rate in HIV-1 env DNA induced by endogenous APOBEC3 proteins using massively parallel sequencing

Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013.

Inhibition of drug-resistant HIV-1 by RNA interference

Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients

Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history

Low prevalence of transmitted HIV-1 drug resistance detected by a dried blood spot (DBS)-based next-generation sequencing (NGS) method in newly diagnosed individuals in Cameroon in the years 2015-16.

Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing

MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing

Mining for pairs: shared clinic visit dates identify steady HIV-positive partnerships.

Minority K65R variants and early failure of antiretroviral therapy in HIV-1-infected Eritrean immigrant

Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients

Molecular characterisation of Lac s 1, the major allergen from lettuce (Lactuca sativa).

Molecular cloning, expression and characterization of Pru a 1, the major cherry allergen.

Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4(+) T cells

Next-generation sequencing of HIV-1 RNA genomes: determination of error rates and minimizing artificial recombination

No Effect of Pegylated Interferon-alpha on Total Hiv-1 DNA Load in HIV-1/HCV Coinfected Patients.

Noninferiority of Simplified Dolutegravir Monotherapy Compared to Continued Combination Antiretroviral Therapy That Was Initiated During Primary Human Immunodeficiency Virus Infection: A Randomized, Controlled, Multisite, Open-label, Noninferiority

Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection

Parallel evolution of HIV-1 in a long-term experiment

Persistence of drug-resistant HIV-1 and possible implications for antiretroviral therapy

Persistence of lamivudine-sensitive HIV-1 quasispecies in the presence of lamivudine in vitro and in vivo.

Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naïve patients

Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection

Rapid decline of anti-hepatitis C virus (HCV) antibodies following early treatment of incident HCV infections in HIV-infected men who have sex with men.

Rapid selection of drug-resistant HIV-1 during the first months of suppressive ART in treatment-naive patients

Rational design of HIV-1 fluorescent hydrolysis probes considering phylogenetic variation and probe performance.

Reappearance of minority K103N HIV-1 variants after interruption of ART initiated during primary HIV-1 infection

Recovering networks from distance data

Reply to correspondence 'Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a "stochastic" process' by Gonzalez et al., Retrovirology 2017.

Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine.

Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector.

Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study

Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α.

Tailored enrichment strategy detects low abundant small noncoding RNAs in HIV-1 infected cells

Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques

The antiretroviral potency of emtricitabine is approximately 3-fold higher compared to lamivudine in dual human immunodeficiency virus type 1 infection/competition experiments in vitro

Tracing HIV-1 strains that imprint broadly neutralizing antibody responses

Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs

Unravelling HIV-1 Latency, One Cell at a Time

Using longitudinally sampled viral nucleotide sequences to characterize the drivers of HIV-1 transmission

Viral Diversity Based on Next-Generation Sequencing of HIV-1 Provides Precise Estimates of Infection Recency and Time Since Infection

Women in the European Virus Bioinformatics Center