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List of works by Joris Deelen

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

scientific article published on 23 February 2015

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

scientific article published on 30 August 2011

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

scientific article published on 22 September 2016

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

scientific article

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

scientific article published on 15 August 2016

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

scientific article

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

scientific article

Biological interpretation of genome-wide association studies using predicted gene functions

scientific article published on 19 January 2015

Blood lipids influence DNA methylation in circulating cells

scientific article published on 27 June 2016

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

scientific article

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 7 July 2017

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Disease variants alter transcription factor levels and methylation of their binding sites

scientific article published on 5 December 2016

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene

scientific article published on 10 April 2012

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

scientific article published on 29 June 2016

Exome and whole genome sequencing in aging and longevity.

scientific article published on January 2015

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

scientific article

Gene expression analysis of mTOR pathway: association with human longevity

scientific article published on 23 November 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

scientific article published in Nature Communications

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

scientific article published on 19 February 2020

How to deal with the early GWAS data when imputing and combining different arrays is necessary

scientific article

IL7R gene expression network associates with human healthy ageing

scientific article

Identification of context-dependent expression quantitative trait loci in whole blood

scientific article published on 5 December 2016

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

scientific article published on 19 February 2013

IgG glycosylation and DNA methylation are interconnected with smoking

scientific article

LDL cholesterol still a problem in old age? A Mendelian randomization study

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

scientific article

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

scientific article

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms. ⬇️

scientific article

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

scientific article

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

scientific article published on 16 January 2013

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

scientific article published on 14 August 2020

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015

Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

scientific article published on 16 July 2020

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

scientific article

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Novel loci and pathways significantly associated with longevity

scientific article published on 25 February 2016

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Searching for the genetic key to a long and healthy life

scientific article published on 24 April 2020

Sex Differences in Genetic Associations With Longevity

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

scientific article

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

scientific article

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

scientific article published on 14 May 2013

The MC1R Gene and Youthful Looks

scientific article published on 27 April 2016

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

scientific article published on 14 December 2016

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

scientific article published on 29 January 2016

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

scientific article

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