List of works by Sven J van der Lee

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

scientific article published on 19 June 2017

A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk

scientific article published on January 2014

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

scientific article published on June 2016

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

article by Sven J. van der Lee et al published 27 May 2019 in Acta Neuropathologica

A novel Alzheimer disease locus located near the gene encoding tau protein.

scientific article

A novel method for serum lipoprotein profiling using high performance capillary isotachophoresis

scientific article

ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure

scientific article published on 30 January 2015

Age at onset of genetic (E200K) and sporadic Creutzfeldt-Jakob diseases is modulated by the gene

article

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

scientific article

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts.

scientific article published on 28 February 2018

Association of common genetic variants with brain microbleeds: A Genome-wide Association Study

scientific article published on 10 September 2020

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 01 May 2019

Blood-based metabolic signatures in Alzheimer's disease

scientific article published on 6 September 2017

Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease.

scientific article published on 26 September 2018

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy

scientific article published on 24 May 2017

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

scientific article

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

scientific article

Common genetic variants influence human subcortical brain structures

scientific article

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

scientific article published on 7 June 2021

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

scientific article published on 18 January 2020

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

scientific article published on 21 October 2019

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on November 2016

EIF2AK3 variants in Dutch patients with Alzheimer's disease

scientific article published on 24 August 2018

Erratum: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

article

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease

scientific article published on 18 June 2016

Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.

scientific article published on 19 July 2016

Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology

scientific article

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic architecture of subcortical brain structures in 38,851 individuals

scientific article published on 21 October 2019

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

scientific article

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

scientific article published on 22 September 2020

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on 18 April 2016

Genome-wide Association Study Links APOEϵ4 and BACE1 Variants with Plasma Amyloid β Levels

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

scientific article published in Nature Communications

Gray matter heritability in family-based and population-based studies using voxel-based morphometry

scientific article

Haplotype reference consortium panel: Practical implications of imputations with large reference panels

scientific article published on 10 May 2017

Heritability of the shape of subcortical brain structures in the general population

scientific article published on 15 December 2016

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

article

Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology

scientific article published on 28 January 2015

Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

Metabolic network failures in Alzheimer's disease: A biochemical road map.

scientific article published on 21 March 2017

Metabolic profiling of intra- and extracranial carotid artery atherosclerosis

scientific article published on 08 March 2018

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study

scientific article published on 28 July 2017

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 12 March 2018

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

scientific article published on 10 January 2017

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

Novel Genetic Loci Associated With Retinal Microvascular Diameter

scientific article published on 13 November 2015

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

PLD3 variants in population studies

scientific article published on April 2015

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

scientific article

Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project

article

Quantifying prion disease penetrance using large population control cohorts

scientific article published on January 2016

Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

scientific article

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

scientific article

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 29 May 2018

The association of vascular disorders with incident dementia in different age groups

scientific article published on 17 May 2019

The dystrophin gene and cognitive function in the general population

scientific article published on 17 September 2014

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

scientific article published on 16 March 2018

The global impact of non-communicable diseases on healthcare spending and national income: a systematic review

scientific article

The global impact of non-communicable diseases on households and impoverishment: a systematic review

scientific article published on 21 December 2014

The global impact of non-communicable diseases on macro-economic productivity: a systematic review

scientific article

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

article

Paulina is supported by:

About Paulina

Help