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List of works by Alexandre F. Stewart

9p21 and the genetic revolution for coronary artery disease.

scientific article

9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells

scientific article published on 20 October 2015

A common allele on chromosome 9 associated with coronary heart disease

scientific article

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

scientific article

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

scientific article

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

scientific article

A genomic revolution for cardiovascular disease-a progress report at five years

scientific article published on 01 June 2011

Adiposity significantly modifies genetic risk for dyslipidemia.

scientific article

Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1B and alpha1D but induction of alpha1C.

scientific article published in March 1996

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

scientific article published on 21 March 2019

Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data

scientific article published on 13 July 2020

Clinical and genetic association of serum ceruloplasmin with cardiovascular risk.

scientific article published on 10 November 2011

Clonal isolation of different strains of mouse mammary tumor virus-like DNA sequences from both the breast tumors and non-Hodgkin's lymphomas of individual patients diagnosed with both malignancies.

scientific article published on September 2004

Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts.

scientific article published in October 1994

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury.

scientific article

Distribution of alpha 1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with alpha 1B and alpha 1D.

scientific article published in May 1994

Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

scientific article published on 14 October 2011

Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia

scientific article published on 03 May 2007

From genes to regenerative medicine: approaches in development.

scientific article published in November 2008

Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.

scientific article

Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet-induced weight loss

scientific article

Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?

scientific article published on July 2014

Gene dosage of the common variant 9p21 predicts severity of coronary artery disease

scientific article published in August 2010

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

scientific article published on 23 September 2010

Genetics of coronary artery disease in the 21st century.

scientific article published on 15 May 2012

Genomics in Cardiovascular Disease ⬇️

scientific article published on March 21, 2013

Genomics in coronary artery disease: past, present and future

scientific article

Genomics: Is It Ready for Primetime? ⬇️

scientific article published on January 1, 2012

Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors

scientific article published on 24 February 2020

IRF2BP2 3'UTR Polymorphism Increases Coronary Artery Calcification in Men

scientific article published on 25 October 2021

IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression.

scientific article

IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care.

scientific article

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

scientific article

Identification of a novel muscle A-type lamin-interacting protein (MLIP)

scientific article (publication date: 3 June 2011)

Identification of human homologues of the mouse mammary tumor virus receptor.

scientific article

Improved Prediction of Cardiovascular Disease Based on a Panel of Single Nucleotide Polymorphisms Identified Through Genome-Wide Association Studies ⬇️

scientific article published on August 21, 2010

Increased genetic risk for obesity in premature coronary artery disease.

scientific article published on 29 July 2015

Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery

scientific article published in November 2017

Interferon-γ activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype.

scientific article published on 28 November 2012

Is atherosclerosis fundamental to human aging? Lessons from ancient mummies.

scientific article

Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study

scientific article published in April 2009

LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia

scientific article published on January 2014

LMO4 is required to maintain hypothalamic insulin signaling.

scientific article published on 14 June 2014

LMO4 mRNA stability is regulated by extracellular ATP in F11 cells.

scientific article published on 28 March 2007

Lack of association of chromosome 9p21.3 genotype with cardiovascular function in persons with stable coronary artery disease: The heart and soul study

scientific article published on 05 April 2009

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.

scientific article

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

scientific article published on May 2017

Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.

scientific article published on 19 July 2017

MMTV-related env sequences in human breast tumor.

scientific article

Making Sense of Genome-Wide Association Studies

scientific article published on 22 December 2014

Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation

scientific article (publication date: 13 December 2002)

Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes.

scientific article

Mouse mammary tumor virus (MMTV)-like DNA sequences in the breast tumors of father, mother, and daughter.

scientific article published on 28 February 2008

Mouse viruses and human disease

article

Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice

scientific article published on 08 January 2020

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis ⬇️

scientific article published on 12 October 2016

Partitioning the heritability of coronary artery disease highlights the importance of immune-mediated processes and epigenetic sites associated with transcriptional activity

scientific article

Personalized genomic medicine: a future prerequisite for the prevention of coronary artery disease.

scientific article published on January 2006

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

scientific article (publication date: 11 August 2012)

Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies

scientific article

Prevalence and correlates of diabetes in South asian indians in the United States: findings from the metabolic syndrome and atherosclerosis in South asians living in america study and the multi-ethnic study of atherosclerosis.

scientific article

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies

scientific article

Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD.

scientific article

Recent success in the discovery of coronary artery disease genes.

scientific article published on 04 August 2011

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study

scientific article published on 26 May 2017

Revisiting the MMTV Zoonotic Hypothesis to Account for Geographic Variation in Breast Cancer Incidence

scientific article published on 09 March 2022

STrengthening the REporting of Genetic Association studies (STREGA)—an extension of the STROBE statement

article

Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation

scientific article

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

scientific article published on 21 March 2019

TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters

scientific article (publication date: 21 June 2002)

TEF-1 transcription factors regulate activity of the mouse mammary tumor virus LTR.

scientific article published on September 2002

Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum

scientific article published on 16 December 2011

The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling.

scientific article published on July 2013

The genetics of coronary artery disease

article

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Transcription Factor RTEF-1 Mediates α 1 -Adrenergic Reactivation of the Fetal Gene Program in Cardiac Myocytes ⬇️

scientific article published on July 13, 1998

Transcription cofactor Vgl-2 is required for skeletal muscle differentiation.

scientific article

Transcriptomic Signature of Atherosclerosis in the Peripheral Blood: Fact or Fiction?

scientific article published on December 2016

Troponin I protein kinase C phosphorylation sites and ventricular function

scientific article published on 01 August 2004

Two Chromosome 9p21 Haplotype Blocks Distinguish Between Coronary Artery Disease and Myocardial Infarction Risk ⬇️

scientific article published on May 31, 2013

Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.

scientific article published on 12 May 2004

Why did ancient people have atherosclerosis?: from autopsies to computed tomography to potential causes

scientific article

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