List of works - Leonardo Manzoni

4-Aminoproline-based arginine-glycine-aspartate integrin binders with exposed ligation points: practical in-solution synthesis, conjugation and binding affinity evaluation.

scientific article published on 6 October 2009

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

scientific article published on 13 April 2017

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

scientific article

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

scientific article

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

scientific article

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

scientific article published on March 2015

Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting ⬇️

scientific article published on March 24, 2011

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

scientific article published in April 2009

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

scientific article published in November 2009

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

scientific article published on July 2015

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

scientific article

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

scientific article

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

scientific article

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

scientific article published on 22 August 2016

Enhancement of the uptake and cytotoxic activity of doxorubicin in cancer cells by novel cRGD-semipeptide-anchoring liposomes.

scientific article published on 22 May 2014

Froc: a new fluorous protective group for peptide and oligosaccharide synthesis

scientific article published on 01 March 2006

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

scientific article published in May 2005

Functionalized cyclic RGD peptidomimetics: conjugable ligands for αvβ3 receptor imaging.

scientific article

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

scientific article published in 2012

Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors

scientific article published on 3 February 2017

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

scientific article published on 9 January 2018

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

scientific article published on 21 September 2017

MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction.

scientific article published on 15 May 2013

Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.

scientific article published in March 2003

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

scientific article published on 26 February 2016

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

scientific article

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

scientific article published on 8 July 2010

Rapid synthesis of oligosaccharides using an anomeric fluorous silyl protecting group.

scientific article

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

scientific article

Regulation of HuR structure and function by dihydrotanshinone-I.

scientific article

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

scientific article published in September 2001

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

scientific article

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

scientific article published on 16 April 2014

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

scientific article

Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag

scientific article published on 01 November 2004

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

scientific article published on 7 October 2005

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

scientific article

List of works by Leonardo Manzoni

4-Aminoproline-based arginine-glycine-aspartate integrin binders with exposed ligation points: practical in-solution synthesis, conjugation and binding affinity evaluation.

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting ⬇️

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

Enhancement of the uptake and cytotoxic activity of doxorubicin in cancer cells by novel cRGD-semipeptide-anchoring liposomes.

Froc: a new fluorous protective group for peptide and oligosaccharide synthesis

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

Functionalized cyclic RGD peptidomimetics: conjugable ligands for αvβ3 receptor imaging.

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction.

Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

Rapid synthesis of oligosaccharides using an anomeric fluorous silyl protecting group.

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Regulation of HuR structure and function by dihydrotanshinone-I.

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

Synthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tag

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles