List of works - Daniele Lecis

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

scientific article published on 13 April 2017

Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.

scientific article published on 8 August 2017

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

scientific article published on 27 November 2013

Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

scientific article

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

scientific article

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

scientific article published in Scientific Reports

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.

scientific article

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

scientific article

Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10

scientific article published on 14 October 2014

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

scientific article

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

scientific article published on 22 August 2016

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

scientific article

Expression quantitative trait analysis reveals fine germline transcript regulation in mouse lung tumors

scientific article published on 7 March 2016

Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

scientific article published on 17 July 2014

Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.

scientific article published on 4 May 2019

Infiltrating mast cell-mediated stimulation of estrogen receptor activity in breast cancer cells promotes the luminal phenotype

scientific article published on 16 March 2020

Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.

scientific article

Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members

scientific article published on 28 December 2016

MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner

scientific article published on 20 March 2018

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

scientific article published on 28 August 2017

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

scientific article published on 14 November 2018

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

scientific article

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

scientific article published on 8 July 2010

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

scientific article

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

scientific article

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

scientific article

SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis

scientific article published on 04 May 2021

SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.

scientific article published on 25 March 2014

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

scientific article

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

scientific article

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

scientific article

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

scientific article

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs

scientific article published on 16 August 2018

Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

scientific article published on 26 November 2021

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

scientific article published on 7 December 2017

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

scientific article published on 16 April 2014

Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells

scientific article published on 23 September 2017

Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

scientific article published on 25 January 2019

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

scientific article

The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies

scientific article

The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.

scientific article published on 16 April 2009

When Failure Is Worse Than Giving Up: The Case of CTL

scientific article published on 01 April 2019

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.

scientific article published on 19 April 2018

List of works by Daniele Lecis

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

Expression quantitative trait analysis reveals fine germline transcript regulation in mouse lung tumors

Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.

Infiltrating mast cell-mediated stimulation of estrogen receptor activity in breast cancer cells promotes the luminal phenotype

Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.

Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members

MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis

SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs

Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells

Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies

The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.

When Failure Is Worse Than Giving Up: The Case of CTL

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.