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List of works by Harry Vrieling

(6-4) photoproducts and not cyclobutane pyrimidine dimers are the main UV-induced mutagenic lesions in Chinese hamster cells.

scientific article published on January 1992

AT base pairs are the main target for mutations at the hprt locus of rat skin fibroblasts exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea

scientific article published on 01 September 1994

Adverse outcome pathways: opportunities, limitations and open questions

scientific article published on 19 October 2017

Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2

scientific article published on 13 May 2020

An efficient pipeline for the generation and functional analysis of human BRCA2 variants of uncertain significance.

scientific article published on 11 September 2014

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

scientific article published on 22 April 2019

Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity

scientific article (publication date: October 2006)

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

scientific article published on 10 March 2017

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

scientific article

Cellular‐signaling pathways unveil the carcinogenic potential of chemicals ⬇️

scientific article published on January 22, 2013

Contributions from molecular/biochemical approaches in epidemiology to cancer risk assessment and prevention ⬇️

scientific article published on November 1, 1992

Deciphering the RNA landscape by RNAome sequencing

scientific article

Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.

scientific article

Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice ⬇️

scientific article published on July 1, 1998

Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation

scientific article

Enhanced UV-induced mutagenesis in the UV61 cell line, the Chinese hamster homologue of Cockayne's syndrome B, is associated with defective transcription coupled repair of cyclobutane pyrimidine dimers.

scientific article published on October 1998

Enhanced global genome nucleotide excision repair reduces UV carcinogenesis and nullifies strand bias in p53 mutations in Csb-/- mice

scientific article published on 11 February 2010

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population

scientific article published in September 1992

Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models

scientific article published on 20 August 2009

Frequent homologous recombination deficiency in high-grade endometrial carcinomas

article

Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment

scientific article published on 24 June 2014

Gene and sequence specificity of DNA damage induction and repair: consequences for mutagenesis.

scientific article

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status.

scientific article

Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells.

scientific article published on 9 June 2008

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

scientific article published on 17 October 2011

Heterozygous Aprt mouse model: detection and study of a broad range of autosomal somatic mutations in vivo

scientific article published in January 1999

Human HPRT mutant database: software for data entry and retrieval

scientific article published on January 1, 1992

Impairment of nucleotide excision repair by apoptosis in UV-irradiated mouse cells ⬇️

scientific article published on 01 May 1998

Mechanism and timing of mitotic rearrangements in the subtelomeric D4Z4 repeat involved in facioscapulohumeral muscular dystrophy

scientific article

Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines

scientific article

Meeting report. Second EU-US workshop on systems level understanding of DNA damage responses

scientific article published on 01 July 2006

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11 ⬇️

scientific article published on February 26, 1998

Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress, ionising or ultraviolet radiation

scientific article

Molecular analysis of mutations affecting hprt mRNA splicing in human T-lymphocytes in vivo

scientific article published on 01 January 1992

Molecular analysis of mutations induced by N-ethyl-N-nitrosourea at the HPRT locus in mouse lymphoma cells

scientific article published on 01 March 1988

Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.

scientific article

Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions

N-acetylated and deacetylated 4'-fluoro-4-aminobiphenyl and 4-aminobiphenyl adducts differ in their ability to inhibit DNA replication of single-stranded M13 in vitro and of single-stranded phi X174 in Escherichia coli

scientific article published on 01 May 1992

No threshold for the induction of chromosomal damage at clinically relevant low doses of X rays

scientific article published on 2 April 2012

Nucleotide excision repair in differentiated cells

scientific article published on August 2006

Nucleotide sequence determination of point mutations at the mouse HPRT locus using in vitro amplification of HPRT mRNA sequences

scientific article published on 01 March 1988

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

scientific article

Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination

scientific article published on 20 January 2017

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment

scientific article published on 05 February 2014

Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action

scientific article published on 18 March 2020

Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity

scientific article published on 8 January 2014

Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra.

scientific article

Skipping Nonsense to Maintain Function: The Paradigm of BRCA2 Exon 12

scientific article published on 11 February 2020

Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells

scientific article published on February 5, 1992

Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene ⬇️

scientific article published on May 11, 1991

Strand-specific mutation induction by 1,2-dibromomethane at the hypoxanthine-guanine phosphoribosyltransferase locus of Chinese hamster ovary cells ⬇️

scientific article published on January 1, 1998

Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.

scientific article published on November 1991

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells

scientific article published on 22 January 2013

The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.

scientific article

The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding.

scientific article published on 29 December 2015

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals ⬇️

scientific article published on October 14, 2011

The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions.

scientific article

The design of a new mutation model for active genes: expression of the Escherichia coli lac operon in mammalian cells ⬇️

scientific article published on September 1, 1997

The functional impact of variants of uncertain significance in BRCA2

scientific article published on 10 July 2018

The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat.

scientific article

The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage

scientific journal article

Transcription coupled repair and its impact on mutagenesis ⬇️

scientific article published on May 25, 1998

Transcription initiation of Mu mom depends on methylation of the promoter region and a phage-coded transactivator ⬇️

scientific article published on January 27, 1983

Transcription-coupled repair: impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors

scientific article

UV-induced hprt mutations in a UV-sensitive hamster cell line from complementation group 3 are biased towards the transcribed strand

scientific article published on August 1, 1992

UV-induced photolesions, their repair and mutations ⬇️

scientific article published on May 1, 1993

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

scientific article

Xenobiotic metabolism in differentiated human bronchial epithelial cells

scientific article published on 13 October 2016

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