List of works - Harry Vrieling

Adverse outcome pathways: opportunities, limitations and open questions

scientific article published on 19 October 2017

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

scientific article

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

scientific article

The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions.

scientific article

Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment

scientific article published on 24 June 2014

The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage

scientific journal article

Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity

scientific article (publication date: October 2006)

Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene

scientific article published on May 11, 1991

Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation

scientific article

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

scientific article published on 22 April 2019

Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.

scientific article

Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells

scientific article published on February 5, 1992

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

scientific article published on 17 October 2011

Transcription initiation of Mu mom depends on methylation of the promoter region and a phage-coded transactivator

scientific article published on January 27, 1983

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

scientific article published on October 14, 2011

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

scientific article

Nucleotide sequence determination of point mutations at the mouse HPRT locus using in vitro amplification of HPRT mRNA sequences

scientific article published on 01 March 1988

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11

scientific article published on February 26, 1998

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population

scientific article published in September 1992

Mechanism and timing of mitotic rearrangements in the subtelomeric D4Z4 repeat involved in facioscapulohumeral muscular dystrophy

scientific article

Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress, ionising or ultraviolet radiation

scientific article

Human HPRT mutant database: software for data entry and retrieval

scientific article published on January 1, 1992

Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.

scientific article published on November 1991

Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines

scientific article

Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment

scientific article published on 05 February 2014

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status.

scientific article

The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat.

scientific article

(6-4) photoproducts and not cyclobutane pyrimidine dimers are the main UV-induced mutagenic lesions in Chinese hamster cells.

scientific article published on January 1992

Molecular analysis of mutations affecting hprt mRNA splicing in human T-lymphocytes in vivo

scientific article published on 01 January 1992

The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding.

scientific article published on 29 December 2015

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

scientific article published on 10 March 2017

Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity

scientific article published on 8 January 2014

AT base pairs are the main target for mutations at the hprt locus of rat skin fibroblasts exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea

scientific article published on 01 September 1994

UV-induced hprt mutations in a UV-sensitive hamster cell line from complementation group 3 are biased towards the transcribed strand

scientific article published on August 1, 1992

UV-induced photolesions, their repair and mutations

scientific article published on May 1, 1993

Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells.

scientific article published on 9 June 2008

Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models

scientific article published on 20 August 2009

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells

scientific article published on 22 January 2013

Nucleotide excision repair in differentiated cells

scientific article published on August 2006

Transcription-coupled repair: impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors

scientific article

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

scientific article published on May 31, 2015

Enhanced UV-induced mutagenesis in the UV61 cell line, the Chinese hamster homologue of Cockayne's syndrome B, is associated with defective transcription coupled repair of cyclobutane pyrimidine dimers.

scientific article published on October 1998

Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.

scientific article

Molecular analysis of mutations induced by N-ethyl-N-nitrosourea at the HPRT locus in mouse lymphoma cells

scientific article published on 01 March 1988

Deciphering the RNA landscape by RNAome sequencing

scientific article

Transcription coupled repair and its impact on mutagenesis

scientific article published on May 25, 1998

The functional impact of variants of uncertain significance in BRCA2

scientific article published on 10 July 2018

Frequent homologous recombination deficiency in high-grade endometrial carcinomas

article

The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.

scientific article

List of works by Harry Vrieling

Adverse outcome pathways: opportunities, limitations and open questions

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions.

Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment

The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage

Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity

Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene

Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.

Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

Transcription initiation of Mu mom depends on methylation of the promoter region and a phage-coded transactivator

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

Nucleotide sequence determination of point mutations at the mouse HPRT locus using in vitro amplification of HPRT mRNA sequences

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population

Mechanism and timing of mitotic rearrangements in the subtelomeric D4Z4 repeat involved in facioscapulohumeral muscular dystrophy

Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress, ionising or ultraviolet radiation

Human HPRT mutant database: software for data entry and retrieval

Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.

Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines

Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status.

The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat.

(6-4) photoproducts and not cyclobutane pyrimidine dimers are the main UV-induced mutagenic lesions in Chinese hamster cells.

Molecular analysis of mutations affecting hprt mRNA splicing in human T-lymphocytes in vivo

The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding.

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity

AT base pairs are the main target for mutations at the hprt locus of rat skin fibroblasts exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea

UV-induced hprt mutations in a UV-sensitive hamster cell line from complementation group 3 are biased towards the transcribed strand

UV-induced photolesions, their repair and mutations

Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells.

Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells

Nucleotide excision repair in differentiated cells

Transcription-coupled repair: impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

Enhanced UV-induced mutagenesis in the UV61 cell line, the Chinese hamster homologue of Cockayne's syndrome B, is associated with defective transcription coupled repair of cyclobutane pyrimidine dimers.

Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.

Molecular analysis of mutations induced by N-ethyl-N-nitrosourea at the HPRT locus in mouse lymphoma cells

Deciphering the RNA landscape by RNAome sequencing

Transcription coupled repair and its impact on mutagenesis

The functional impact of variants of uncertain significance in BRCA2

Frequent homologous recombination deficiency in high-grade endometrial carcinomas

The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.