List of works by David-Alexandre Trégouët

A Follow-Up Study of a Genome-wide Association Scan Identifies a Susceptibility Locus for Venous Thrombosis on Chromosome 6p24.1

scholarly article by Pierre-Emmanuel Morange et al published April 2010 in American Journal of Human Genetics

A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1.

scientific article

A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium

scientific article published on 05 May 2013

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

scientific article

A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis

scientific article

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

scientific article

A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.

scientific article published on 19 December 2013

A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies.

scientific article

A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm.

scientific article published in March 2004

A novel channelopathy in pulmonary arterial hypertension

scientific article published on July 2013

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

article

A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project.

scientific article published on 13 April 2011

A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians

scientific article

A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant

scientific article published on 19 January 2021

A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein

scientific article published in Scientific Reports

ABO Blood Group and von Willebrand Factor Levels Partially Explained the Incomplete Penetrance of Congenital Thrombophilia

article

APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients.

scientific article published on 4 January 2018

Activated thrombin activatable fibrinolysis inhibitor levels are associated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGenestudy

scientific article published on 01 January 2009

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

scientific article

Adrenomedullin and arterial stiffness: integrative approach combining monocyte ADM expression, plasma MR-Pro-ADM, and genome-wide association study.

scientific article published on 22 July 2014

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

scientific article published on 23 February 2015

An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism

scientific article published on 07 July 2021

Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European Populations: Strongest Evidence for Association With a Variant in the Promoter Region of the Adiponectin Gene

article

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

scientific article published in August 2012

Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.

scientific article published on 20 May 2017

Association between Angiotensin-Converting Enzyme Gene Polymorphisms and Diabetic Nephropathy: Case-Control, Haplotype, and Family-Based Study in Three European Populations

article

Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women

scientific article published on 01 September 2018

Association of Plasminogen Activator Inhibitor (PAI)-1 (SERPINE1) SNPs With Myocardial Infarction, Plasma PAI-1, and Metabolic Parameters

scientific article published on 26 July 2007

Association of impaired renal function with venous thrombosis: A genetic risk score approach

scientific article published on 25 August 2017

Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study

scientific article

Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus

scientific article published on 28 July 2011

Associations of PPARGC1A Haplotypes With Plaque Score but Not With Intima-Media Thickness of Carotid Arteries in Middle-Aged Subjects

scientific article published on 10 August 2006

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Automated detection of informative combined effects in genetic association studies of complex traits.

scientific article

Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH.

scientific article published on 11 September 2017

C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies

scientific article

Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis

scientific article (publication date: 2012)

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Combined effects of genetic and environmental factors on insulin resistance associated with reduced fetal growth.

scientific article published in December 2002

Combined segregation-linkage analysis of plasma thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels with TAFI gene polymorphisms

article

Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach.

scientific article published on 10 March 2009

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

scientific article published on 17 May 2016

Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression

scientific article

Correction: Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene Expression.

scientific article published on 5 October 2012

Cox proportional hazards survival regression in haplotype-based association analysis using the Stochastic-EM algorithm.

scientific article published in November 2004

Current knowledge on the genetics of incident venous thrombosis.

scientific article published on June 2013

Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.

scientific article

DNA methylation age is associated with an altered hemostatic profile in a multi-ethnic meta-analysis

article

DNA methylation and body-mass index: a genome-wide analysis

scientific article

EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension.

scientific article published in December 2013

Effect of cytochrome P450 2C19 genotype on voriconazole exposure in cystic fibrosis lung transplant patients

scientific article published on 31 October 2010

Environmental and genetic factors associated with morphine response in the postoperative period

article

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456

scientific article published on 27 April 2020

Erratum: Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

article

European rational approach for the genetics of diabetic complications--EURAGEDIC: patient populations and strategy

scientific article (publication date: 2008)

Exome-wide association study on Albuminuria identifies a novel rare variant in CUBN and additional genes, in 33,985 Europeans with and without diabetes

article

Exploration of Multilocus Effects in a Highly Polymorphic Gene, the Apolipoprotein (APOB) Gene, in Relation to Plasma apoB Levels

article

Familial aggregation of fetal growth restriction in a French cohort of 7,822 term births between 1971 and 1985.

scientific article published in July 2002

Familial aggregation of metabolic syndrome indicators in Portuguese families.

scientific article published on 22 September 2013

Familial resemblance of physical activity levels in the Portuguese population

scientific article published on 18 September 2013

Family study of the relationship between height and cardiovascular risk factors in the STANISLAS cohort.

scientific article published in August 2003

Fibrogenic Potential of PW1/Peg3 Expressing Cardiac Stem Cells

scientific article published in August 2017

Fine mapping of quantitative trait nucleotides underlying thrombin-activatable fibrinolysis inhibitor antigen levels by a transethnic study.

scientific article published on 16 May 2006

GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, "GENEREPOL study": Lack of common variants with large effect sizes.

scientific article published on 11 August 2017

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

scientific article

Genetic Variations at the Endocannabinoid Type 1 Receptor Gene (CNR1) Are Associated with Obesity Phenotypes in Men

article

Genetic determinants of risk and survival in pulmonary arterial hypertension

article

Genetic determinants of tissue factor pathway inhibitor plasma levels.

scientific article published on 16 April 2015

Genetic evidence of assortative mating in humans

article

Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts

scientific article

Genetic risk factors for venous thrombosis in women using combined oral contraceptives: update of the PILGRIM study.

scientific article published on 14 July 2016

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility

scientific article (publication date: 18 May 2010)

Genetics of Venous Thrombosis: update in 2015

article

Genetics of venous thrombosis: insights from a new genome wide association study

scientific article (publication date: 2011)

Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project

article

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

scientific article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

scientific article

Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels

scientific article published on 4 January 2017

Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes

scientific article

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

scientific article published on 8 February 2009

Genome-wide investigation of DNA methylation marks associated with FV Leiden mutation.

scientific article

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genomewide association analysis of coronary artery disease

scientific article

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

scientific article

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

scientific article

Graphical modeling of gene expression in monocytes suggests molecular mechanisms explaining increased atherosclerosis in smokers

scientific article

Haplotype Effect of the Matrix Metalloproteinase-1 Gene on Risk of Myocardial Infarction

article

Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project

article

Heterogeneity of linkage disequilibrium in human genes has implications for association studies of common diseases

article

High prevalence of laminopathies among patients with metabolic syndrome

scientific article published on 30 June 2011

Homocysteine concentration in coronary artery disease: Influence of three common single nucleotide polymorphisms.

scientific article published on 17 September 2016

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

scientific article published on 9 October 2017

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

scientific article published on 01 September 2018

Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome

scientific article published on 15 July 2013

Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels.

scientific article published in January 2011

In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoA1 levels and myocardial infarction.

scientific article published on 12 February 2004

Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism

scientific article

Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease.

scientific article published on 11 December 2009

Influence of sex and genetic variability on expression of X-linked genes in human monocytes.

scientific article

Influence of three potential genetic risk factors for thrombosis in 43 families carrying the factor V Arg 506 to Gln mutation

scientific article published on 01 September 1999

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans

scientific article

Investigation of the human ANP gene in type 1 diabetic nephropathy: case-control and follow-up studies

scientific article published in May 2004

Is there still room for additional common susceptibility alleles for venous thromboembolism?

scientific article published on 21 June 2016

KNG1 Ile581Thr and susceptibility to venous thrombosis

scientific article published on 26 January 2011

Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project

scientific article

Lack of association of non-synonymous FUT2 and ALPL polymorphisms with venous thrombosis

scientific article published on 01 August 2012

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Lessons from genome-wide association studies in venous thrombosis.

scientific article published on July 2011

Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels.

scientific article published on 18 April 2017

Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci

scientific article

MACARON: a python framework to identify and re-annotate multi-base affected codons in whole genome/exome sequence data

scholarly article by Waqasuddin Khan published in May 2018

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo.

scientific article

Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

scientific article

Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

scientific article published in April 2004

Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies

scientific article published on 17 April 2014

Merkel cell polyomavirus infection occurs during early childhood and is transmitted between siblings

scientific article published on 2 July 2013

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

scientific article

Metabolic determinants are much more important than genetic polymorphisms in determining the PAI-1 activity and antigen plasma concentrations: a family study with part of the Stanislas Cohort

scientific article published in January 1998

Minor allele of the factor V K858R variant protects from venous thrombosis only in non-carriers of factor V Leiden mutation

scientific article published on 06 March 2019

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

scientific article published on 28 November 2018

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

Multilocus genetic risk scores for venous thromboembolism risk assessment

scientific article

Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: Genetic determinants for atherosclerosis?

scientific article published on 10 November 2005

New susceptibility loci associated with kidney disease in type 1 diabetes

scientific article

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

scientific article published on 08 February 2009

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

scientific article

Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes.

scientific article

P-selectin polymorphisms’ influences on P-selectin serum concentrations and on their familial correlation: the STANISLAS family study

scientific article published on 21 March 2008

PARVG Gene Polymorphism and Operational Renal Allograft Tolerance

article

PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.

scientific article published on 14 October 2016

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.

scientific article published on 12 April 2010

Pharmacogenetics of acenocoumarol pharmacodynamics.

scientific article published in May 2004

Plasma levels of hsa-miR-152-3p are associated with diabetic nephropathy in patients with type 2 diabetes.

scientific article

Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach.

scientific article published on 19 July 2007

Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

scientific article

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

scientific article

Protein S Heerlen mutation heterozygosity is associated with venous thrombosis risk.

scientific article published on 04 April 2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article

Quantification of thrombin activatable fibrinolysis inhibitor (TAFI) gene polymorphism effects on plasma levels of TAFI measured with assays insensitive to isoform-dependent artefact

article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Removing Batch Effects from Longitudinal Gene Expression - Quantile Normalization Plus ComBat as Best Approach for Microarray Transcriptome Data

scientific article

Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease

scientific article published on 24 March 2008

Respective roles of serological status and blood specific antihuman herpesvirus 8 antibody levels in human herpesvirus 8 intrafamilial transmission in a highly endemic area.

scientific article published in December 2004

Risk factors for venous thromboembolism in women under combined oral contraceptive

Robust validation of methylation levels association at CPT1A locus with lipid plasma levels

scientific article

Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages

scientific article

SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease.

scientific article published in November 2003

SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes

scientific article

Serum myeloperoxidase concentration in a healthy population: biological variations, familial resemblance and new genetic polymorphisms

scientific article published on 01 October 2001

Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis

scientific article

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

scientific article published on 28 September 2017

Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma

article

Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism.

scientific article

Small platelet microparticle levels are increased in pulmonary arterial hypertension.

scientific article

Specific haplotypes of the P-selectin gene are associated with myocardial infarction.

scientific article published in August 2002

Testing Association between Candidate-Gene Markers and Phenotype in Related Individuals, by Use of Estimating Equations ⬇️

scientific article published on July 1, 1997

The A −844G Polymorphism in the PAI-1 Gene Is Associated With a Higher Risk of Venous Thrombosis in Factor V Leiden Carriers

article

The Genetic Landscape of Renal Complications in Type 1 Diabetes

scientific article

The choice of the filtering method in microarrays affects the inference regarding dosage compensation of the active X-chromosome

scientific article

The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.

scientific article published on 17 January 2012

The factor XII -4C>T variant and risk of common thrombotic disorders: A HuGE review and meta-analysis of evidence from observational studies.

scientific article

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

Thrombin Generation Potential and Whole-Blood DNA methylation

article

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure

scientific article published on 07 August 2017

Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.

scientific article

What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies

article

miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice

scientific article

miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells

scientific article

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