List of works by David Karasik

A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study

scientific article

A combined reference panel from the 1000 Genomes and UK10K projects improved rare variant imputation in European and Chinese samples

scientific article published on 22 December 2016

A genome wide linkage scan of metacarpal size and geometry in the Framingham Study

scientific article published on November 2008

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation

scientific article

A genome-wide association study of aging

scientific article

A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

scientific article published on 16 December 2013

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

scientific article

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of the transferability of bone mineral density genetic loci associations from European to African ancestry populations

scientific article published on 29 November 2020

A systematic evaluation of 151 candidate genes for their association with osteoporosis and osteoporotic fracture in a meta-analysis of genome-wide association data

article

Abdominal aortic calcification and exostoses at the hand and lumbar spine: the Framingham Study

scientific article published on 6 January 2006

Age, gender, and body mass effects on quantitative trait loci for bone mineral density: the Framingham Study

scientific article published on 01 September 2003

An Atlas of Human and Murine Genetic Influences on Osteoporosis

An atlas of genetic influences on osteoporosis in humans and mice

scientific article published on 31 December 2018

An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits

scientific article

Anthropometric characteristics of men in Antarctica

scientific article published in July 1999

Assessment of gene-by-sex interaction effect on bone mineral density

scientific article (publication date: October 2012)

Association analyses of 47,500 individuals identifies six fracture loci and 82 BMD loci clustering in biological pathways that regulate osteoblast and osteoclast activity

Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies.

scientific article

Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status

scientific article published on 22 December 2003

Association of heat shock proteins with all-cause mortality

scientific article published on 04 May 2012

Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis.

scientific article

Author Correction: An atlas of genetic influences on osteoporosis in humans and mice

scientific article published on 01 May 2019

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

scientific article

Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study

scientific article published on April 2009

Bivariate linkage study of proximal hip geometry and body size indices: the Framingham study

scientific article published on 3 August 2007

Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study

scientific article published on 19 July 2017

Bone ageing: genetics versus environment

scientific article

Bone geometry and skeletal fragility

scientific article published on June 2006

Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study.

scientific article

Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture

scientific article

Common Genetic Determinants of Vitamin D Insufficiency: A Genome-Wide Association Study

Common genetic determinants of vitamin D insufficiency: a genome-wide association study

scientific article

Comparative analysis of age prediction by markers of bone change in the hand assessed by roentgenography

scientific article

Complex segregation analysis of the radiographic phalanges bone mineral density and their age-related changes

scientific article published in January 2002

Contribution of gender-specific genetic factors to osteoporosis risk.

scientific article published on 08 May 2008

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 7 July 2017

Corrigendum: Rare coding variants and X-linked loci associated with age at menarche

scientific article published on 17 December 2015

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

scientific article published on 19 December 2013

Discovery and replication of several loci significantly associated with lean body mass: a large meta-analysis of genome wide association studies (GWAS) from the 'charge' and 'gefos' consortia

Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures

scientific article

Disentangling the genetics of lean mass

article

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study

scientific article

Evidence for pleiotropic factors in genetics of the musculoskeletal system

scientific article

Evidence of major gene control of cortical bone loss in humans

scientific article published on December 2000

Evidence on major gene control of cortical index in pedigree data from Middle Dalmatia, Croatia

scientific article

FABP4 is a leading candidate gene associated with residual feed intake in growing Holstein calves.

scientific article published on 18 March 2016

Fluctuating asymmetry and morphometric variation of hand bones

scientific article

Functional Validation of Osteoporosis Genetic Findings Using Small Fish Models

scientific article published on 31 January 2022

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

scientific article

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

scientific article

Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons

scientific article

Genes play an important role in bone aging

scientific article published in January 1998

Genetic Pleiotropy of Bone-Related Phenotypes: Insights from Osteoporosis

scientific article published on 08 September 2020

Genetic basis of falling risk susceptibility in the UK Biobank Study

scientific article published on 30 September 2020

Genetic contribution to biological aging: the Framingham Study

scientific article

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

scientific article

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

scientific article

Genetic determinants of serum testosterone concentrations in men.

scientific article

Genetic diversity is a predictor of mortality in humans

scientific article

Genetic variation and covariation of parathyroid hormone levels and bone density in the human population

scientific article published on 01 March 2000

Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men

scientific article published on 28 November 2006

Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density

scientific article published on 28 January 2012

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

Genetics of Bone and Muscle Interactions in Humans

article

Genetics of the musculoskeletal system: a pleiotropic approach

scientific article (publication date: June 2008)

Genome screen for a combined bone phenotype using principal component analysis: the Framingham study

scientific article published on March 2004

Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham Study

scientific article

Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition

Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?

scientific article

Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide association with bone mass and geometry in the Framingham Heart Study

scientific article published in 2007

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

scientific article

Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study

scientific article (publication date: July 2010)

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

scientific article published on 24 April 2017

Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families.

scientific article published on 15 July 2016

Heritability of Thoracic Spine Curvature and Genetic Correlations With Other Spine Traits: The Framingham Study

scientific article published on 25 July 2016

Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study

scientific article

Hip geometry variation is associated with bone mineralization pathway gene variants: The Framingham Study.

scientific article published in July 2010

Hip structural geometry in old and old-old age: similarities and differences between men and women

scientific article

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

scientific article (publication date: March 2011)

Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations

scientific article published in June 2011

Identification of novel loci associated with hip shape: a meta-analysis of genome-wide association studies

Impact of common variation in bone-related genes on type 2 diabetes and related traits

scientific article

Impact of the environment on the skeleton: is it modulated by genetic factors?

scientific article

Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip.

scientific article published on 26 February 2008

Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women.

scientific article published on 04 September 2002

Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study

scientific article published on 5 January 2004

Intrauterine stress induces bone loss in adult offspring of C3H/HeJ mice having high bone mass phenotype but not C57BL/6J mice with low bone mass phenotype

scientific article published on 9 April 2016

Large common deletions associate with mortality at old age.

scientific article

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

scientific article published in December 2015

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis

scientific article published on March 2008

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

scientific article published in November 2015

Leukocyte telomere length pattern in a Chuvash population that experienced mass famine in 1922-1923: a retrospective cohort study

scientific article published on 12 October 2016

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

scientific article published in January 2018

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

scientific article

METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.

scientific article

Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis

scientific article published in October 2002

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

scientific article

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

scientific article

Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels

scientific article

Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass

scientific article

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

scientific article published on March 2013

Meta‐Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry

scientific article published on 19 March 2019

Modelling of age-related bone loss using cross-sectional data

scientific article

Models to explore genetics of human aging

scientific article published on January 2015

Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map

scientific article

Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2.

scientific article published in August 2016

Novel therapeutic intervention for osteoporosis prepared with strontium hydroxyapatite and zoledronic acid: In vitro and pharmacodynamic evaluation.

scientific article published on 26 October 2016

Osteoporosis genetics: year 2011 in review

scientific article published on August 2012

Osteoporosis: an evolutionary perspective

scientific article

PPARG by dietary fat interaction influences bone mass in mice and humans

scientific article published on September 2008

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

scientific article

Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans

scientific article published on 29 September 2007

Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis Study

scientific article

Rare coding variants and X-linked loci associated with age at menarche

scientific article

Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe

scientific article

Searching for parent-of-origin effects on cardiometabolic traits in imprinted genomic regions

scientific article published on 02 January 2020

Seated Tai Chi to alleviate pain and improve quality of life in individuals with spinal cord disorder

scientific article published on 25 February 2016

Segregation analysis reveals a major gene effect in compact and cancellous bone mineral density in 2 populations

scientific article

Statistical genetic analysis of plasma levels of vitamin D: familial study

scientific article

Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship?

scientific article published on 07 August 2013

Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship?

scientific article

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study

scientific article published on 11 September 2016

The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community

scientific article published on 10 August 2020

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The effect of season, occupation and repeated winterings on anthropologic and physiological characteristics in Russian antarctic staff.

scientific article

The genetic pleiotropy of musculoskeletal aging.

scientific article

The genetics of bone mass and susceptibility to bone diseases

scientific article published on 01 July 2016

The genetics of bone mass and susceptibility to bone diseases.

scientific article published on 7 April 2016

The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study

scientific article published on 27 June 2013

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

scientific article

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

scientific article

Twenty loci associated with bone mineral density identified by large-scale meta-analysis of genome-wide association datasets

Use of the hand bones roentgenographs in the prediction of age in nine human populations

scientific article published on June 2000

Violent mortality patterns in immigrants in Israel (1990-95).

scientific article

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

scientific article

Zebrafish models of sarcopenia

scientific article published on 30 March 2020

Paulina is supported by:

About Paulina

Help