List of works - Amy R. Howell

1,4-Dicarbofunctionalization of 4-Fluoroaryl Grignard and Lithium Reagents with Disubstituted Malononitriles

scientific article published on 12 April 2017

A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase

scientific article published on 01 April 1998

A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity

scientific article

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

scientific article

A Solvent-free Approach to Glycosyl Amides: Towards the Synthesis of α-N-Galactosyl Ceramides

scientific article published on June 2015

A Versatile Preparation of 2-Methyleneoxetanes

scientific article published on 01 October 1996

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.

scientific article published on 31 March 2008

A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids

scientific article

Access to Oxetane-Containingpsico-Nucleosides from 2-Methyleneoxetanes: A Role for Neighboring Group Participation?

scientific article published on 15 November 2011

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

scientific article published on 08 October 2009

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

scientific article published on December 2009

Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation

scientific article published on November 2008

Amide-Linked C4″-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model

scientific article published on 09 December 2020

An unusual and efficient reaction of 2-methylene-3-phenyloxetane in the presence of lithium and 4,4′-di-tert-butylbiphenyl in THF

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.

scientific article published on 15 February 2016

Cloning and characterization of a hybridoma secreting a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-specific monoclonal antibody and recombinant F(ab)

scientific article

Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases

scientific article

Contact sensitizers trigger human CD1-autoreactive T-cell responses

scientific article published on 25 April 2017

Cross Metathesis of α-Methylene Lactones II: γ- and δ-Lactones

scientific article published on 04 April 2007

Cross Metathesis with Strained Exocyclic Enones: Synthesis of 3-Alkylideneoxetan-2-ones from 3-Methyleneoxetan-2-ones

scientific article published on 01 May 2006

Design and Synthesis of an Activity-Based Probe Template for Protein Kinases

Directed ring-opening of 1,5-dioxaspiro[3.2]hexanes: selective formation of 2,2-disubstituted oxetanes

scientific article published in February 2003

Glycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T Cells

scientific article

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

scientific article

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

scientific article

Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation

scientific article published on June 2009

Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation

scientific article published on 27 May 2015

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

scientific article

Multiphoton excited fabrication of collagen matrixes cross-linked by a modified benzophenone dimer: bioactivity and enzymatic degradation

scientific article published in May 2005

Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells

scientific article

Natural killer T-cell autoreactivity leads to a specialized activation state

scientific article published on 08 September 2008

Pd-Catalyzed Acyl C-O Bond Activation for Selective Ring-Opening of α-Methylene-β-lactones with Amines

scientific article published on 4 April 2017

Preparation of 2-alkylidene oxetanes: An investigation of the Paterno-Büchi reaction between aliphatic aldehydes and allenes

Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d

scientific article published on 5 April 2007

Pt-catalyzed rearrangement of oxaspirohexanes to 3-methylenetetrahydrofurans: scope and mechanism

scientific article

Recent Applications of Oxetanes in the Synthesis of Heterocyclic Compounds

scientific article published on 19 August 2015

Recognition of lyso-phospholipids by human natural killer T lymphocytes

scientific article

Rh-Catalyzed Conjugate Addition of Aryl and Alkenyl Boronic Acids to α-Methylene-β-lactones: Stereoselective Synthesis of trans-3,4-Disubstituted β-Lactones

scientific article published in 2017

Rhodium-Catalyzed Addition of Aryl Boronic Acids to 2,2-Disubstituted Malononitriles

scientific article

Scaling Proteome-Wide Reactions of Activity-Based Probes.

scientific article published in June 2017

Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation

scientific article published on 9 September 2015

Silicon acceleration of a tandem alkene isomerization/electrocyclic ring-opening of 2-methyleneoxetanes to α,β-unsaturated methylketones

scientific article

Stereospecificity of 2-methylpiperidine binding to a nicotinic up-regulatory site in the rat brain P2 preparation

scientific article published in October 1985

Straightforward synthesis of sphinganines via a serine-derived Weinreb amide

scientific article published in April 2004

Synthesis and Reactions of 2-Alkylidene Thiiranes and Thietanes

Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.

scientific article published on 6 June 2009

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.

scientific article published on 18 May 2009

Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.

scientific article published in December 2005

Synthesis of a 2"-deoxy-β-GalCer

scientific article

Synthesis of epi-oxetin via a serine-derived 2-methyleneoxetane

scientific article

Synthesis ofd-erythro-Dihydrosphingosine andd-xylo-Phytosphingosine from a Serine-Derived 1,5-Dioxaspiro[3.2]hexane Template

scientific article published on 01 May 2002

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire

scientific article

T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells

scientific article published on 15 December 2005

The Alpha and Omega of Galactosylceramides in T Cell Immune Function

scientific article published on 6 May 2015

The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition

scholarly article

The alpha and omega of galactosylceramides in T cell immune function.

scientific article published in August 2015

The molecular bases of δ/αβ T cell-mediated antigen recognition.

scientific article

The reaction of dimethyltitanocene with N-substituted-β-lactams

Toward a formal synthesis of laureatin: unexpected rearrangements involving cyclic ether nucleophiles

scientific article published on 5 September 2012

Unexpected cleavage of 2-azido-2-(hydroxymethyl)oxetanes: conformation determines reaction pathway?

scientific article published on 18 October 2010

Unusual, Strained Heterocycles: 3-Alkylidene-2-methyleneoxetanes from Morita−Baylis−Hillman-type Adducts†

scientific article published on 01 February 2003

V 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

scientific article

Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents

scientific article

List of works by Amy R. Howell

1,4-Dicarbofunctionalization of 4-Fluoroaryl Grignard and Lithium Reagents with Disubstituted Malononitriles

A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase

A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

A Solvent-free Approach to Glycosyl Amides: Towards the Synthesis of α-N-Galactosyl Ceramides

A Versatile Preparation of 2-Methyleneoxetanes

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.

A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids

Access to Oxetane-Containingpsico-Nucleosides from 2-Methyleneoxetanes: A Role for Neighboring Group Participation?

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation

Amide-Linked C4″-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model

An unusual and efficient reaction of 2-methylene-3-phenyloxetane in the presence of lithium and 4,4′-di-tert-butylbiphenyl in THF

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.

Cloning and characterization of a hybridoma secreting a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-specific monoclonal antibody and recombinant F(ab)

Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases

Contact sensitizers trigger human CD1-autoreactive T-cell responses

Cross Metathesis of α-Methylene Lactones II: γ- and δ-Lactones

Cross Metathesis with Strained Exocyclic Enones: Synthesis of 3-Alkylideneoxetan-2-ones from 3-Methyleneoxetan-2-ones

Design and Synthesis of an Activity-Based Probe Template for Protein Kinases

Design and Synthesis of an Activity-Based Probe Template for Protein Kinases

Directed ring-opening of 1,5-dioxaspiro[3.2]hexanes: selective formation of 2,2-disubstituted oxetanes

Glycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T Cells

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation

Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

Multiphoton excited fabrication of collagen matrixes cross-linked by a modified benzophenone dimer: bioactivity and enzymatic degradation

Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells

Natural killer T-cell autoreactivity leads to a specialized activation state

Pd-Catalyzed Acyl C-O Bond Activation for Selective Ring-Opening of α-Methylene-β-lactones with Amines

Preparation of 2-alkylidene oxetanes: An investigation of the Paterno-Büchi reaction between aliphatic aldehydes and allenes

Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d

Pt-catalyzed rearrangement of oxaspirohexanes to 3-methylenetetrahydrofurans: scope and mechanism

Recent Applications of Oxetanes in the Synthesis of Heterocyclic Compounds

Recognition of lyso-phospholipids by human natural killer T lymphocytes

Rh-Catalyzed Conjugate Addition of Aryl and Alkenyl Boronic Acids to α-Methylene-β-lactones: Stereoselective Synthesis of trans-3,4-Disubstituted β-Lactones

Rhodium-Catalyzed Addition of Aryl Boronic Acids to 2,2-Disubstituted Malononitriles

Scaling Proteome-Wide Reactions of Activity-Based Probes.

Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation

Silicon acceleration of a tandem alkene isomerization/electrocyclic ring-opening of 2-methyleneoxetanes to α,β-unsaturated methylketones

Stereospecificity of 2-methylpiperidine binding to a nicotinic up-regulatory site in the rat brain P2 preparation

Straightforward synthesis of sphinganines via a serine-derived Weinreb amide

Synthesis and Reactions of 2-Alkylidene Thiiranes and Thietanes

Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.

Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.

Synthesis of a 2"-deoxy-β-GalCer

Synthesis of epi-oxetin via a serine-derived 2-methyleneoxetane

Synthesis ofd-erythro-Dihydrosphingosine andd-xylo-Phytosphingosine from a Serine-Derived 1,5-Dioxaspiro[3.2]hexane Template

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire

T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells

The Alpha and Omega of Galactosylceramides in T Cell Immune Function

The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition

The alpha and omega of galactosylceramides in T cell immune function.

The molecular bases of δ/αβ T cell-mediated antigen recognition.

The reaction of dimethyltitanocene with N-substituted-β-lactams

Toward a formal synthesis of laureatin: unexpected rearrangements involving cyclic ether nucleophiles

Unexpected cleavage of 2-azido-2-(hydroxymethyl)oxetanes: conformation determines reaction pathway?

Unusual, Strained Heterocycles: 3-Alkylidene-2-methyleneoxetanes from Morita−Baylis−Hillman-type Adducts†

V 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents