List of works - Alba Chimirri

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

scientific article published on 27 November 2010

3-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]-1,3-oxazolidin-2-one ⬇️

scientific article published on April 13, 2011

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

scientific article

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

scientific article published on 20 February 2014

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

scientific article published on 8 April 2008

A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus

scientific article

AMPA receptor antagonists as potential anticonvulsant drugs

scientific article

Anti-HIV agents: design and discovery of new potent RT inhibitors

scientific article

Binding modes of noncompetitive AMPA antagonists: a computational approach

scientific article

Combined strategies for the discovery of ionotropic glutamate receptor antagonists

scientific article

Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodents

scientific article

Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents

scientific article published in February 2003

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

scientific article published in May 2005

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

scientific article published in October 2008

Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

scientific article published in February 2002

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 30 December 2013

Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents

scientific article

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents

scientific article published on November 2002

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

scientific article published on 31 December 2008

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process

scientific article published on 25 March 2014

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

scientific article

Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

scientific article published on 19 January 2007

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions

scientific article

Efficient 3D database screening for novel HIV-1 IN inhibitors

scientific article published in July 2004

Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy

scientific article published on 2 June 2008

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

scientific article

From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands

scientific article published on 15 November 2013

Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants ⬇️

scientific article published on January 1, 2012

Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block

scientific article published in September 2002

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

scientific article

Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS

scientific article

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies

scientific article

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

scientific article published on 2 June 2013

Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.

scientific article published in September 2009

Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75 ⬇️

scientific article published on April 19, 2011

Molecular dynamics studies of the full-length integrase-DNA complex

scientific article published in November 2005

Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistance

scientific article

New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors

scientific article

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action

scientific article published on 22 June 2010

Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors

scientific article

Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

scientific article published on March 2003

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

scientific article published on November 2005

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

scientific article published in August 2009

Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors

scientific article published on 9 June 2008

Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation

scientific article published on 20 March 2010

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

scientific article published on 17 September 2010

Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides

scientific article published on 7 March 2008

Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents

scientific article

Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides

scientific article

Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors

scientific article

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors

scientific article

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives

scientific article published in September 2002

Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles

scientific article published on October 2002

Synthesis and anticonvulsant activity of N-3 substituted 2,3-benzodiazepines

scientific article published in May 2004

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

scientific article published on 29 November 2007

Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives

scientific article published in January 2004

Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors

scientific article published on 16 November 2011

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors

scientific article published on 16 July 2013

Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

scientific article published on 7 April 2009

Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives

scientific article published in August 2003

Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants

scientific article published on December 2010

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

scientific article published in January 2004

Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors

scientific article

Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors

scientific article

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

scientific article published on 12 March 2008

Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode

scientific article published on 14 September 2007

List of works by Alba Chimirri

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

3-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]-1,3-oxazolidin-2-one ⬇️

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus

AMPA receptor antagonists as potential anticonvulsant drugs

Anti-HIV agents: design and discovery of new potent RT inhibitors

Binding modes of noncompetitive AMPA antagonists: a computational approach

Combined strategies for the discovery of ionotropic glutamate receptor antagonists

Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodents

Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions

Efficient 3D database screening for novel HIV-1 IN inhibitors

Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands

Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants ⬇️

Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.

Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75 ⬇️

Molecular dynamics studies of the full-length integrase-DNA complex

Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistance

New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action

Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors

Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors

Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides

Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents

Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides

Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives

Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles

Synthesis and anticonvulsant activity of N-3 substituted 2,3-benzodiazepines

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives

Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors

Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives

Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors

Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode