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List of works by Zeger Debyser

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

scientific article (publication date: 3 January 2003)
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

scientific article
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

scientific article
Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

scientific article published on October 2010
Transportin-SR2 imports HIV into the nucleus

scientific article
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

scientific article published in March 2007
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

scientific article
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

scientific article published on 25 April 2005
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

scientific article
Cellular co-factors of HIV-1 integration

scientific article
The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites

scientific article
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

scientific article
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin

scientific article
Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

scientific article
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

scientific article published on 8 March 2011
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

scientific article published on 30 May 2013
LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

scientific article
Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction

scientific article
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

scientific article published in March 2007
Comparison of lentiviral vector titration methods

scientific article published on 12 July 2006
Highly efficient multicistronic lentiviral vectors with peptide 2A sequences

scientific article published on August 2009
Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75

scientific article
Upscaling of lentiviral vector production by tangential flow filtration

scientific article
Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction

scientific article published in May 2010
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain

scientific article
Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7

scientific article published on 01 April 1994
Novel targets for HIV therapy

scientific article
Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity

scientific article
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

scientific article published on January 5, 2013
Identification of the LEDGF/p75 binding site in HIV-1 integrase

scientific article
Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

scientific article
Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain

scientific article published in December 2003
miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors

scientific journal article
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

scientific article published in August 2009
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

scientific article published on 17 August 2006
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

scientific article published on November 2003
Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

scientific article published on 12 July 2007
Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain

scientific article
Host factors for retroviral integration site selection

scientific article published on 31 December 2014
Single-cell imaging of HIV-1 provirus (SCIP).

scientific article published on 19 March 2013
Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.

scientific article published on December 2009
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering

scientific article
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

scientific article published on June 1999
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region

scientific article
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

scientific article published on November 2005
Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis

scientific article published on 2 November 2006
Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo

scientific article published in June 2006
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

scientific article
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.

scientific article published in October 2004
The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

scientific article published on 03 May 2013

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