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List of works by Zeger Debyser

2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance

article

2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance

scientific article

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

scientific article published on 27 November 2010

4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors

scientific article

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

scientific article

A PET brain reporter gene system based on type 2 cannabinoid receptors

scientific article

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

scientific article published on 20 February 2014

A novel surgical approach for intratracheal administration of bioactive agents in a fetal mouse model

scientific article

A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression

scientific article published on 30 November 2007

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

scientific article published on 8 April 2008

A short course on virology / vectorology / gene therapy

scientific article published in December 2003

A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication

scientific article

A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors

scientific article published on 18 January 2011

Alteration of Cardiac Progenitor Cell Potency in GRMD Dogs ⬇️

scientific article published in September 2012

Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75.

scientific article published on August 2008

Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression

scientific article published on September 2011

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

scientific article published on 29 July 2014

Bioluminescence imaging of stroke-induced endogenous neural stem cell response

scientific article published on 27 May 2014

Bioluminescence imaging of therapy response does not correlate with FDG-PET response in a mouse model of Burkitt lymphoma

scientific article published on 10 July 2012

Biosafety of lentiviral vectors

scientific article published on December 2003

Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration

scientific article published on 17 March 2020

Cellular co-factors of HIV-1 integration

scientific article

Cellular cofactors of lentiviral integrase: from target validation to drug discovery

scientific article published on 7 August 2012

Characterization of lentiviral vector-mediated gene transfer in adult mouse brain

scientific article

Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors

scientific article

Chemical crosslinking of the subunits of HIV-1 reverse transcriptase.

scientific article published on February 1996

Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF.

scientific article published on 31 July 2012

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

scientific article published in March 2007

Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation

scientific article published on 7 June 2011

Comparison of lentiviral vector titration methods

scientific article published on 12 July 2006

Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis

scientific article published on 2 November 2006

Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7

scientific article published on 01 April 1994

DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy

scientific article

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

scientific article published on 8 March 2011

Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase

scientific article published on 30 July 2014

Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity

scientific article

Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors

scientific article published on 24 June 2013

Design of reverse transcriptase-specific nucleosides to visualize early steps of HIV-1 replication by click labeling

scientific article published on 14 June 2019

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

scientific article

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

scientific article published on 30 April 2012

Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors

scientific article published on 14 February 2012

Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

scientific article published on November 2003

Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction

scientific article published in May 2010

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

scientific article

Diffusion of myelin oligodendrocyte glycoprotein in living OLN-93 cells investigated by raster-scanning image correlation spectroscopy (RICS).

scientific article

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process

scientific article published on 25 March 2014

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

scientific article published on 22 June 2015

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction

scientific article published on 2 August 2013

Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions

scientific article published on 20 December 2012

Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors

scientific article published on 10 October 2007

Discovery of small molecule HIV-1 integrase dimerization inhibitors

scientific article published on 21 March 2012

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions

scientific article

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication

scientific article published on October 2017

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry

scientific article published on 10 November 2016

Efficient 3D database screening for novel HIV-1 IN inhibitors

scientific article published in July 2004

Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2.

scientific article published on 27 July 2010

Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction.

scientific article published in November 2007

Elvitegravir: a once daily alternative to raltegravir

scientific article published on 18 October 2011

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

scientific article published on 12 April 2017

Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof

scientific article published on March 2003

Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells.

scientific article

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex

scientific article published on 27 May 2015

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors

scientific article

Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication

scientific article published on March 2004

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T

scientific article

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease

scientific article published on 21 January 2015

Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain.

scientific article published in March 1998

Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model.

scientific article published in April 2007

Fetal surgery is a clinical reality

scientific article

Five-drug antiretroviral therapy for primary HIV infection?

scientific article published on 18 February 2015

Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity

scientific article published on 2 June 2008

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

scientific article

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction

scientific article published on 18 March 2013

Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa.

scientific article published in April 1999

Galectin-1 in melanoma biology and related neo-angiogenesis processes.

scientific article published on 24 May 2012

HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.

scientific article

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

scientific article (publication date: 3 January 2003)

HIV-1 integrase inhibition: looking at cofactor interactions

scientific article published on 15 December 2015

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

scientific article

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort

scientific article published on 12 November 2014

HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins

scientific article

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

scientific article

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease

scientific article published on 24 November 2015

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region

scientific article

Highly efficient multicistronic lentiviral vectors with peptide 2A sequences

scientific article published on August 2009

Host factors for retroviral integration site selection

scientific article published on 31 December 2014

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75

scientific article

Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein

scientific article

Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor

scientific article published on 27 August 2013

Identification of the LEDGF/p75 binding site in HIV-1 integrase

scientific article

Immunohistochemical detection of transgene expression in the brain using small epitope tags

scientific article

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways

scientific article published on 26 March 2014

Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction

scientific article

In search of authentic inhibitors of HIV-1 integration

scientific article

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer

scientific article published on October 2009

In search of small molecules blocking interactions between HIV proteins and intracellular cofactors

scientific article published on 16 October 2008

In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75.

scientific article

In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma.

scientific article published on 12 September 2008

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

scientific article published in February 2010

Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives

scientific article

Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.

scientific article

Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import

scientific article published on 12 January 2018

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis

scientific article published on 10 March 2008

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection

scientific article published on January 2017

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

scientific article published on 25 April 2005

Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)

scientific article

Interplay between HIV entry and transportin-SR2 dependency

scientific article

Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors

scientific article published on 14 May 2014

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

scientific article

Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

scientific article published on 11 September 2015

LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin

scientific article

LEDGF/p75 is critical but not essential for multiple-round HIV 1 replication.

scientific article

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

scientific article published on 30 October 2017

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

scientific article

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

scientific article

LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

scientific article published on 13 May 2016

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

scientific article published on 30 May 2013

LEDGINs, a novel class of antivirals targeting HIV integrase during integration and assembly.

scientific article published on 19 September 2013

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

scientific article published on 25 March 2014

Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

scientific article

Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model.

scientific article published on 14 February 2012

Lentiviral nuclear import: a complex interplay between virus and host

scientific article

Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain

scientific article published in December 2003

Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo

scientific article published in June 2006

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia

scientific article

Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1.

scientific article published on 22 May 2007

Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy

scientific article

Long-term stability of human immunodeficiency virus viral load and infectivity in whole blood.

scientific article published in May 1999

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors

scientific article published on 17 December 2014

Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function

scientific article published on 2 March 2011

Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75.

scientific article published on 23 March 2005

Mode of Interaction of G-Quartets with the Integrase of Human Immunodeficiency Virus Type 1 ⬇️

scientific article published on November 1, 1997

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI.

scientific article published on 19 February 2010

Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.

scientific article published in October 2004

Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology

scientific article published on January 2005

Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.

scientific article

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

scientific article published on April 2003

N-terminal half of transportin SR2 interacts with HIV integrase.

scientific article published on 29 March 2017

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.

scientific article published on December 2009

Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein

scientific article published in July 2003

New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent

scientific article published on 26 May 2010

New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors

scientific article

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action

scientific article published on 22 June 2010

New class of HIV integrase inhibitors that block viral replication in cell culture

scientific article published on July 2002

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays

scientific article published on 9 August 2013

Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity

scientific article published on 11 January 2012

Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression

scientific article published on 19 January 2006

Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector

scientific article published on 15 November 2015

Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging

scientific article published on 3 July 2008

Novel targets for HIV therapy

scientific article

Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors

scientific article published on 03 July 2007

Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

scientific article published on June 1999

Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging.

scientific article

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors

scientific article published on 2 May 2015

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

scientific article

PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide

scientific article published on 23 June 2015

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

scientific article published on 17 August 2006

Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells.

scientific article

Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

scientific article

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

scientific article published on November 2005

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

scientific article published in August 2009

Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors.

scientific article published on March 2005

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

scientific article published on 19 May 2016

Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors

scientific article published on 9 June 2008

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer

scientific article

Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.

scientific article

Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets

scientific article published in June 2017

Quad's in it for antiretroviral therapy?

scientific article published on 01 June 2012

Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain

scientific article

Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors

scientific article published on 19 February 2008

Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

scientific article published on October 2010

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors

scientific article published on 25 July 2016

Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection

scientific article published on December 2013

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

scientific article

Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.

scientific article

Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system

scientific article

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection

scientific article

Rilpivirine: a step forward in tailored HIV treatment

scientific article published on 01 July 2011

Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting

scientific article published on 10 October 2011

Seeing genes at work in the living brain with non-invasive molecular imaging

scientific article

Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

scientific article

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex

scientific article published on July 2015

Simple criterion for selection of flavonoid compounds with anti-HIV activity

scientific article

Single-cell imaging of HIV-1 provirus (SCIP).

scientific article published on 19 March 2013

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

scientific article published on 17 September 2010

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

scientific article

State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations

scientific article published on December 2009

Structural Modification of Diketo Acid Portion in 1H-Benzylindole Derivatives HIV-1 Integrase Inhibitors

article

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran

scientific article

Structure, mechanics, and binding mode heterogeneity of LEDGF/p75–DNA nucleoprotein complexes revealed by scanning force microscopy

scientific article published on 01 May 2014

Switching STRATEGIES in HIV treatment

scientific article published on 5 June 2014

Synthesis and antiviral properties of some polyphenols related to Salvia genus

scientific article

Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging.

scientific article

Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging

scientific article published on 30 March 2007

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors

scientific article published on 16 July 2013

Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography

scientific article published on 8 January 2008

Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography

scientific article published on 14 February 2007

Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging

scientific article published on 16 June 2011

Targeting Virus-host Interactions of HIV Replication

scientific article published on September 2015

Targeting the HIV integration process in antiviral therapy

scientific article published on December 2008

Tenofovir prodrugs: similar but not the same

scientific article published on March 2017

The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites

scientific article

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import

scientific article

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy ⬇️

scientific article published on January 5, 2013

The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy

scientific article published on 12 January 2006

The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication

scientific article published on 31 August 2006

The free energy landscape of retroviral integration

scientific article published on 18 October 2019

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

scientific article

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection

scientific article published on 29 August 2019

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

scientific article published on 03 May 2013

The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity

scientific article published on 24 January 2012

The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.

scientific article published on 27 December 2007

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering

scientific article

Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies

scientific article published on 11 August 2007

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

scientific article published on 22 June 2011

Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD.

scientific article published on 5 March 2013

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

scientific article

Transportin-SR2 imports HIV into the nucleus

scientific article

Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration

scientific article published on 07 May 2011

Upscaling of lentiviral vector production by tangential flow filtration

scientific article

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo

scientific article published on 16 November 2013

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

scientific article

env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors

scientific article

miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors

scientific journal article

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice

scientific article published on 28 October 2015

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