List of works - Emanuele Amata

(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

scientific article published on 8 December 2017

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects

scientific article

4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes

scholarly article in RSC Advances, vol. 5 no. 58, 2015

A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach

A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands

scientific article published on 14 October 2018

Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells

scientific article published on 25 October 2016

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

scientific article

C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.

scientific article published on 9 March 2015

Caspase-3 activation in human melanoma A375 cell line by a novel selective sigma-2 agonist

scientific article published on March 2016

Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis.

scientific article published on 29 May 2017

Evaluation of N-substitution in 6,7-benzomorphan compounds.

scientific article published on 9 June 2010

Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

scientific article published on May 2015

Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist

scientific article published on 23 March 2020

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.

scientific article published on 14 July 2017

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign

scientific article (publication date: October 2014)

Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

scientific article published on 17 January 2016

Identification of potentially potent Heme Oxygenase-1 inhibitors through 3D-QSAR coupled to scaffold hopping analysis.

scientific article

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands

scientific article published on 23 January 2019

Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.

scientific article published on 27 November 2017

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

scientific article published on 18 May 2018

Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery.

scientific article published on 8 July 2015

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.

scientific article

Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors

scientific article

Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.

scientific article

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands

scientific article (publication date: 2017)

Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation

scientific article published on 04 September 2018

Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

scientific article published on 5 May 2018

Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents

scientific article published on 01 July 2019

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines

scientific article published on 17 September 2018

Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis

scientific article published on 18 December 2019

List of works by Emanuele Amata

(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects

4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes

A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach

A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands

Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.

Caspase-3 activation in human melanoma A375 cell line by a novel selective sigma-2 agonist

Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis.

Evaluation of N-substitution in 6,7-benzomorphan compounds.

Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign

Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

Identification of potentially potent Heme Oxygenase-1 inhibitors through 3D-QSAR coupled to scaffold hopping analysis.

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands

Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery.

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.

Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors

Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands

Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation

Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines

Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis