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List of works by Tomohiro Numata

"TRP inflammation" relationship in cardiovascular system

scientific article

A novel inhibitor of hypertonicity-induced cation channels in HeLa cells

scientific article published on 28 June 2007

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure

scientific article

Acid-sensitive outwardly rectifying (ASOR) anion channels in human epithelial cells are highly sensitive to temperature and independent of ClC-3.

scientific article published on 26 May 2013

Active Zone Protein Bassoon Co-Localizes with Presynaptic Calcium Channel, Modifies Channel Function, and Recovers from Aging Related Loss by Exercise ⬇️

scientific article published on June 6, 2012

Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells.

scientific article published on 27 June 2016

Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.

scientific article published on 22 March 2018

Characterization of single L-type Ca2+ channels in myocytes isolated from the cricket lateral oviduct.

scientific article published on 19 April 2005

Characterization of stretch-activated calcium permeable cation channels in freshly isolated myocytes of the cricket (Gryllus bimaculatus) lateral oviduct

scientific article published in May 2005

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

scientific article

Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.

scientific article published on 20 June 2014

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

scientific article published on 15 May 2020

Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line.

scientific article

Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry

scientific article

Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin.

scientific article

Distinct contributions of LRRC8A and its paralogs to the VSOR anion channel from those of the ASOR anion channel

scientific article

Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel

scientific article published on 08 January 2016

Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis.

scientific article published on 28 October 2010

Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels

scientific article published on 29 October 2019

Hypertonicity-induced cation channels rescue cells from staurosporine-elicited apoptosis.

scientific article published on July 2008

Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models

scientific article

Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing.

scientific article

Involvements of the ABC protein ABCF2 and α‐actinin‐4 in regulation of cell volume and anion channels in human epithelial cells ⬇️

scientific article published on October 1, 2012

Mutations in EFHC1 cause juvenile myoclonic epilepsy

scientific article

Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner

scientific article

Optical control of neuronal firing via photoinduced electron transfer in donor-acceptor conjugates

scientific article published on 17 February 2016

Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel.

scientific article published on 26 January 2009

Proton conductivity through the human TRPM7 channel and its molecular determinants

scientific article published on 4 April 2008

Role of acid-sensitive outwardly rectifying anion channels in acidosis-induced cell death in human epithelial cells

scientific article published on 22 December 2006

Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells

scientific article published on 16 September 2015

Signalling events employed in the hypertonic activation of cation channels in HeLa cells

scientific article published on 01 January 2007

TRP channels as sensors of oxygen availability ⬇️

scientific article published on February 17, 2013

TRPM1: a vertebrate TRP channel responsible for retinal ON bipolar function.

scientific article published on August 2010

TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation

scientific article published on 17 November 2015

TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development

scientific article published on 09 April 2019

TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells.

scientific article published on 30 August 2006

TRPM7 is involved in acid-induced necrotic cell death in a manner sensitive to progesterone in human cervical cancer cells

scientific article published on 01 July 2019

Targeting TRPs in neurodegenerative disorders.

scientific article published on January 2013

Temperature sensitivity of acid-sensitive outwardly rectifying (ASOR) anion channels in cortical neurons is involved in hypothermic neuroprotection against acidotoxic necrosis

scientific article

The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death.

scientific article published on 4 January 2012

The ΔC splice-variant of TRPM2 is the hypertonicity-induced cation channel in HeLa cells, and the ecto-enzyme CD38 mediates its activation

scientific article published on 04 January 2012

Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic Nanoparticles

scientific article published on 6 August 2015

Transient receptor potential melastatin 2 protects mice against polymicrobial sepsis by enhancing bacterial clearance

scientific article published in August 2014

Transnitrosylation directs TRPA1 selectivity in N-nitrosamine activators

scientific article published on 7 November 2013

Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches

scientific article

Utilization of Photoinduced Charge-Separated State of Donor–Acceptor-Linked Molecules for Regulation of Cell Membrane Potential and Ion Transport

scientific article published on 2 April 2012

V₂ receptor-mediated autocrine role of somatodendritic release of AVP in rat vasopressin neurons under hypo-osmotic conditions

scientific article published on 25 January 2011

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