List of works by David Malkin

"A change in perspective": Exploring the experiences of adolescents with hereditary tumor predisposition

scientific article published on 11 September 2018

A common molecular mechanism underlies two phenotypically distinct 17p13.1 microdeletion syndromes

scientific article

A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma

scientific article published on August 2005

A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study

scientific article

A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: A Children's Oncology Group (COG) Phase II study NCT00061893.

scientific article

Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers

scientific article

Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk.

scientific article published on 13 December 2016

Attitudes of Canadian researchers toward the return to participants of incidental and targeted genomic findings obtained in a pediatric research setting

scientific article (publication date: July 2013)

Attitudes of parents toward the return of targeted and incidental genomic research findings in children

BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma

scientific article

Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study

scientific article published on 19 May 2011

Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

scientific article

Cancer surveillance for individuals with Li-Fraumeni syndrome

scientific article published on 19 August 2020

Characterization of bone marrow stromal abnormalities in a patient with constitutional trisomy 8 mosaicism and myelodysplastic syndrome

scientific article published on April 2004

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

scientific article published on 01 May 2019

Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study

scientific article published on 10 March 2016

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

scientific article

Copy number variations and cancer

scientific article published on 16 June 2009

Copy number variations and cancer susceptibility

scientific article published on January 2010

Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article published in Nature

Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes

scientific article published on May 2015

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

DNA methylation signature is prognostic of choroid plexus tumor aggressiveness

scientific article published on 13 August 2019

Differentiation of rhabdomyosarcoma cell lines using retinoic acid

scientific article published on November 2006

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article (publication date: 29 January 2012)

Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome

scholarly article

Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors

scientific article published on 12 September 2008

Factors influencing survival in children with recurrent neuroblastoma

scientific article published on April 2004

Gastrointestinal Findings in the Largest Series of Patients With Hereditary Biallelic Mismatch Repair Deficiency Syndrome: Report from the International Consortium

scientific article published on 5 January 2016

Genetics of childhood cancer.

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency

scientific article published on 06 January 2022

Germ-line and somatic DICER1 mutations in pineoblastoma

scientific article

High frequency of mismatch repair deficiency among pediatric high grade gliomas in Jordan

scientific article published on 8 August 2015

Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma

scientific article

Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction

scientific article

Imaging of cancer predisposition syndromes in children

scientific article published on January 2011

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.

scientific article

Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma

scientific article published on 10 February 2014

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

scientific article

Intellectual Outcome in Molecular Subgroups of Medulloblastoma

scientific article published on 9 August 2016

JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma

scientific article published on 26 May 2009

Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium

scientific article published on 29 August 2012

Low prevalence of complications in severe neutropenic children with cancer in the unprotected environment of an overnight camp

scientific article

Lymphomatous involvement of the heart in children: two cases and a review of the literature.

scientific article

Management of Acute Myeloblastic Leukemia in a Child With Biallelic Mismatch Repair Deficiency

scientific article published on 12 August 2015

Medulloblastoma

scientific article published on 14 February 2019

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

scientific article published on 05 April 2016

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

scientific article

Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups

scientific article published on 21 October 2014

Monoallelic expression determines oncogenic progression and outcome in benign and malignant brain tumors

scientific article published on 5 December 2011

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

scientific article published on 07 August 2020

NCO-10INTELLECTUAL OUTCOME IN MOLECULAR SUBGROUPS OF MEDULLOBLASTOMA.

scientific article

Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition

scientific article published in January 2011

Oncogenic ILK, tumor suppression and all that JNK.

scientific article published on 15 December 2009

Oncologic surveillance for subjects with biallelic mismatch repair gene mutations-10 year follow-up in a kindred

scientific article published on 10 March 2011

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

scientific article

PM-10GENETICALLY ENGINEERED MOUSE MODELS OF CHOROID PLEXUS TUMORS.

scientific article published on 21 April 2015

PNR-08NEWLY DISCOVERED ONCOGENES DRIVING AND MAINTAINING CHOROID PLEXUS CARCINOMA PROVIDE POTENTIALLY DRUGGABLE TARGETS.

scientific article published on 30 May 2016

Pediatric Cancer Predisposition and Surveillance: An Overview, and a Tribute to Alfred G. Knudson Jr.

scientific article

Phenotypic and genotypic characterisation of biallelic mismatch repair deficiency (BMMR-D) syndrome

scientific article published on 13 April 2015

Postoperative fevers in pediatric solid tumor patients: how should they be managed?

scientific article published on July 2009

Predisposition to pediatric and hematologic cancers: a moving target

scientific article published on January 2014

Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study

scientific article published on 12 January 2015

Processed pseudogenes acquired somatically during cancer development

scientific article published on 09 April 2014

Proteomic analyses of CSF aimed at biomarker development for pediatric brain tumors

scientific article published on 26 April 2014

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

scientific article published on 19 June 2014

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

scientific article published on 6 November 2011

Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors

scientific article published in Science

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice

scientific article

Retrospective evaluation of a decision-support algorithm (MIPOGG) for genetic referrals for children with neuroblastic tumors

scientific article published on 16 August 2018

Spatial heterogeneity in medulloblastoma

scientific article published on 10 April 2017

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

scientific article

Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth

scientific article published on October 2008

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Super-Transactivation TP53 Variant in the Germline of a Family with Li-Fraumeni Syndrome

scientific article published on 14 June 2016

Surveillance for children at genetic risk for cancer: are we ready?

scientific article published on 11 April 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

TMOD-13GENETICALLY ENGINEERED MOUSE MODELS OF CHOROID PLEXUS TUMORS.

scientific article

TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors

scientific article published on 22 March 2010

Telomere dysfunction and chromothripsis

scientific article published on 9 February 2016

The CXCR4-SDF1alpha axis is a critical mediator of rhabdomyosarcoma metastatic signaling induced by bone marrow stroma

scientific article published on September 2007

The estrogen receptor pathway in rhabdomyosarcoma: a role for estrogen receptor-beta in proliferation and response to the antiestrogen 4'OH-tamoxifen

scientific article published in May 2008

The role of telomere maintenance in the spontaneous growth arrest of pediatric low-grade gliomas

scientific article published in February 2006

The transcriptional landscape of Shh medulloblastoma

scientific article published on 19 March 2021

Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping

scientific article (publication date: October 2010)

Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network

scientific article published on 6 July 2016

Tumor necrosis in pediatric osteosarcoma: impact of modern therapies

scientific article published in July 2006

Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations

scientific article published on 8 February 2010

Unusual ocular presentation of von Hippel-Lindau disease

scientific article published in October 2005

Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid

scientific article published on December 2005

Vitamin E: the evidence for multiple roles in cancer

scientific article

Vulnerability of white matter to insult during childhood: evidence from patients treated for medulloblastoma

scientific article

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

scientific article

p53 and hereditary cancer

scientific article published on January 2014

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