List of works - Christophe Biot

1H-1,2,3-Triazole-Tethered Isatin–Ferrocene and Isatin–Ferrocenylchalcone Conjugates: Synthesis and in Vitro Antitubercular Evaluation

1H-1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation

scientific article published on 12 November 2016

4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation

scientific article

5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials

scientific article

7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation

scientific article published on 14 March 2014

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

scientific article

A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3

scientific article published on 27 September 2019

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

scientific article

A sequential bioorthogonal dual strategy: ManNAl and SiaNAl as distinct tools to unravel sialic acid metabolic pathways.

scientific article published on 5 January 2016

AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes

Alkynyl monosaccharide analogues as a tool for evaluating Golgi glycosylation efficiency: application to Congenital Disorders of Glycosylation (CDG).

scientific article

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

scientific article published on 12 October 2009

Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA.

scientific article published on April 2010

Antiprotozoal activity of ferroquine

scientific article published on 15 November 2012

Asking more from metabolic oligosaccharide engineering

Assessing ER and Golgi N-glycosylation process using metabolic labeling in mammalian cultured cells

scientific article

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure

scientific article

Azide–alkynecycloadditionen route towards 1H-1,2,3-triazole-tethered β-lactam–ferrocene and β-lactam–ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation

scientific article published on 29 October 2012

BLISS: A Bioorthogonal Dual-Labeling Strategy to Unravel Lignification Dynamics in Plants.

scientific article published on 20 February 2017

BLISS: Shining a light on lignification in plants

scientific article published on 8 August 2017

Base-Promoted Expedient Access to Spiroisatins: Synthesis and Antitubercular Evaluation of 1H-1,2,3-Triazole-Tethered Spiroisatin–Ferrocene and Isatin–Ferrocene Conjugates

Bioorganometallic Chemistry and Malaria

article

Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells.

scientific article published on 2 January 2018

Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii

scientific article

Correction: EPR imaging of sinapyl alcohol and its application to the study of plant cell wall lignification

scientific article published on 04 January 2021

Corrigendum to “Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones” [Bioorg. Med. Chem. Lett. 21 (2011) 2866–2868]

scholarly article by Aman Mahajan et al published June 2011 in Bioorganic & Medicinal Chemistry Letters

Deciphering the Resistance-Counteracting Functions of Ferroquine in Plasmodium falciparum-Infected Erythrocytes

scientific article

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

scientific article published on May 2006

Development of novel statistical potentials describing cation-pi interactions in proteins and comparison with semiempirical and quantum chemistry approaches.

scientific article

Double-drug development against antioxidant enzymes from Plasmodium falciparum

scientific article published on January 2003

Du cannabis aux agonistes sélectifs du récepteur CB2

scientific article published on 28 May 2013

EPR imaging of sinapyl alcohol and its application to the study of plant cell wall lignification

scientific article published on 16 December 2020

Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach

scientific article

Exploring the Potential of β-Catenin O-GlcNAcylation by Using Fluorescence-Based Engineering and Imaging

scientific article published on 01 October 2020

Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial.

scientific article published on March 2008

Ferrocene-based antimalarials

scientific article published in April 2012

Ferroquine as an oxidative shock antimalarial

scientific article published on January 2014

Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.

scientific article published on 20 November 2008

Ferroquine, the next generation antimalarial drug, has antitumor activity

scientific article published on 21 November 2017

Free-energy calculations of protein-ligand cation-pi and amino-pi interactions: from vacuum to proteinlike environments

scientific article published in November 2003

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation

scientific article published in Nature Communications

Histidine-Aromatic Interactions in Proteins and Protein-Ligand Complexes: Quantum Chemical Study of X-ray and Model Structures

scientific article published on 01 May 2005

Iminosugar-ferrocene conjugates as potential anticancer agents.

scientific article

Improved workflow for the efficient preparation of ready to use CMP-activated Salic acids

scientific article published on 19 August 2016

In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine ⬇️

scientific article published on March 1, 1998

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

scientific article published on 05 December 2011

In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum.

scientific article published on 13 January 2006

Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.

scientific article published on May 2005

Investigation of the redox behavior of ferroquine, a new antimalarial

scientific article published on 19 June 2008

Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies

scientific article

Medicinal potential of ciprofloxacin and its derivatives

scientific article published on January 2013

MicroPlate Sialyltransferase Assay: A Rapid and Sensitive Assay Based on an Unnatural Sialic Acid Donor and Bioorthogonal Chemistry

scientific article published on 20 September 2018

New heterocyclic compounds: Synthesis and antitrypanosomal properties.

scientific article

One, Two, Three: A Bioorthogonal Triple Labelling Strategy for Studying the Dynamics of Plant Cell Wall Formation In Vivo

scientific article published in 2018

One, two, three: a bioorthogonal triple labelling strategy for studying the dynamics of plant cell wall formation in vivo

article

Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes

scientific article published on 15 June 2012

Organometallic complexes: new tools for chemotherapy.

scientific article published on January 2010

Pharmacokinetics of ferroquine, a novel 4-aminoquinoline, in asymptomatic carriers of Plasmodium falciparum infections

scientific article

Plasmodium falciparum apicoplast drugs: targets or off-targets?

scientific article

Platinum(II) and palladium(II) complexes with (N,N') and (C,N,N')- ligands derived from pyrazole as anticancer and antimalarial agents: synthesis, characterization and in vitro activities.

scientific article

Probing the CMP-Sialic Acid Donor Specificity of Two Human β-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins

scientific article published on 10 April 2017

Probing the energetic and structural role of amino acid/nucleobase cation-pi interactions in protein-ligand complexes

scientific article published on 06 August 2002

Sequence-structure signals of 3D domain swapping in proteins

scientific article published in July 2003

Stair motifs at protein-DNA interfaces: nonadditivity of H-bond, stacking, and cation-pi interactions.

scientific article

Statistical methodology for the detection of small changes in distances by EXAFS: application to the antimalarial ruthenoquine.

scientific article

Structural analysis of an unusual bioactive N-acylated lipo-oligosaccharide LOS-IV in Mycobacterium marinum

scientific article published on 21 October 2010

Structure-Based Design and Synthesis of Piperidinol-Containing Molecules as New Mycobacterium abscessus Inhibitors

scientific article published on 20 March 2020

Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure ⬇️

scientific article published on September 19, 2010

Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.

scientific article published on November 1997

Synthesis and in vitro anti-tubercular evaluation of 1,2,3-triazole tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone chimeric scaffolds

scientific article published on 3 April 2012

Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones.

scientific article

Synthesis of ferroquine enantiomers: first investigation of effects of metallocenic chirality upon antimalarial activity and cytotoxicity.

scientific article published on May 2002

Synthesis, characterization and in vitro anti-Trypanosoma cruzi and anti-Mycobacterium tuberculosis evaluations of cyrhetrenyl and ferrocenyl thiosemicarbazones

scholarly article by Rodrigo Arancibia et al published April 2014 in Journal of Organometallic Chemistry

Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents.

scientific article published on July 2000

Targeting malaria parasite at the level of apicoplast: an update

scientific article published on 27 February 2012

The Many Ways by Which -GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations

scientific article published on 02 November 2018

The antimalarial ferroquine is an inhibitor of hepatitis C virus.

scientific article published on 14 May 2013

The antimalarial ferroquine: from bench to clinic

scientific article

The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance

scientific article published on 7 January 2011

The apicoplast: a key target to cure malaria

scientific article published on January 1, 2012

The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition

scientific article published on 13 June 2013

The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action

scientific article

UDP-GLYCOSYLTRANSFERASE 72E3 Plays a Role in Lignification of Secondary Cell Walls in Arabidopsis

scientific article published on 24 August 2020

What is paradoxical about Levinthal paradox?

scientific article

α-L-fucosidase inhibition by pyrrolidine-ferrocene hybrids: rationalization of ligand-binding properties by structural studies

scientific article

List of works by Christophe Biot

1H-1,2,3-Triazole-Tethered Isatin–Ferrocene and Isatin–Ferrocenylchalcone Conjugates: Synthesis and in Vitro Antitubercular Evaluation

1H-1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation

4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation

5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials

7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

A sequential bioorthogonal dual strategy: ManNAl and SiaNAl as distinct tools to unravel sialic acid metabolic pathways.

AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes

Alkynyl monosaccharide analogues as a tool for evaluating Golgi glycosylation efficiency: application to Congenital Disorders of Glycosylation (CDG).

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA.

Antiprotozoal activity of ferroquine

Asking more from metabolic oligosaccharide engineering

Assessing ER and Golgi N-glycosylation process using metabolic labeling in mammalian cultured cells

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure

Azide–alkynecycloadditionen route towards 1H-1,2,3-triazole-tethered β-lactam–ferrocene and β-lactam–ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation

BLISS: A Bioorthogonal Dual-Labeling Strategy to Unravel Lignification Dynamics in Plants.

BLISS: Shining a light on lignification in plants

Base-Promoted Expedient Access to Spiroisatins: Synthesis and Antitubercular Evaluation of 1H-1,2,3-Triazole-Tethered Spiroisatin–Ferrocene and Isatin–Ferrocene Conjugates

Bioorganometallic Chemistry and Malaria

Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells.

Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii

Correction: EPR imaging of sinapyl alcohol and its application to the study of plant cell wall lignification

Corrigendum to “Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones” [Bioorg. Med. Chem. Lett. 21 (2011) 2866–2868]

Deciphering the Resistance-Counteracting Functions of Ferroquine in Plasmodium falciparum-Infected Erythrocytes

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

Development of novel statistical potentials describing cation-pi interactions in proteins and comparison with semiempirical and quantum chemistry approaches.

Double-drug development against antioxidant enzymes from Plasmodium falciparum

Du cannabis aux agonistes sélectifs du récepteur CB2

EPR imaging of sinapyl alcohol and its application to the study of plant cell wall lignification

Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach

Exploring the Potential of β-Catenin O-GlcNAcylation by Using Fluorescence-Based Engineering and Imaging

Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial.

Ferrocene-based antimalarials

Ferroquine as an oxidative shock antimalarial

Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.

Ferroquine, the next generation antimalarial drug, has antitumor activity

Free-energy calculations of protein-ligand cation-pi and amino-pi interactions: from vacuum to proteinlike environments

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation

Histidine-Aromatic Interactions in Proteins and Protein-Ligand Complexes: Quantum Chemical Study of X-ray and Model Structures

Iminosugar-ferrocene conjugates as potential anticancer agents.

Improved workflow for the efficient preparation of ready to use CMP-activated Salic acids

In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine ⬇️

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum.

Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.

Investigation of the redox behavior of ferroquine, a new antimalarial

Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies

Medicinal potential of ciprofloxacin and its derivatives

MicroPlate Sialyltransferase Assay: A Rapid and Sensitive Assay Based on an Unnatural Sialic Acid Donor and Bioorthogonal Chemistry

New heterocyclic compounds: Synthesis and antitrypanosomal properties.

One, Two, Three: A Bioorthogonal Triple Labelling Strategy for Studying the Dynamics of Plant Cell Wall Formation In Vivo

One, two, three: a bioorthogonal triple labelling strategy for studying the dynamics of plant cell wall formation in vivo

Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes

Organometallic complexes: new tools for chemotherapy.

Pharmacokinetics of ferroquine, a novel 4-aminoquinoline, in asymptomatic carriers of Plasmodium falciparum infections

Plasmodium falciparum apicoplast drugs: targets or off-targets?

Platinum(II) and palladium(II) complexes with (N,N') and (C,N,N')- ligands derived from pyrazole as anticancer and antimalarial agents: synthesis, characterization and in vitro activities.

Probing the CMP-Sialic Acid Donor Specificity of Two Human β-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins

Probing the energetic and structural role of amino acid/nucleobase cation-pi interactions in protein-ligand complexes

Sequence-structure signals of 3D domain swapping in proteins

Stair motifs at protein-DNA interfaces: nonadditivity of H-bond, stacking, and cation-pi interactions.

Statistical methodology for the detection of small changes in distances by EXAFS: application to the antimalarial ruthenoquine.

Structural analysis of an unusual bioactive N-acylated lipo-oligosaccharide LOS-IV in Mycobacterium marinum

Structure-Based Design and Synthesis of Piperidinol-Containing Molecules as New Mycobacterium abscessus Inhibitors

Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure ⬇️

Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.

Synthesis and in vitro anti-tubercular evaluation of 1,2,3-triazole tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone chimeric scaffolds

Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones.

Synthesis of ferroquine enantiomers: first investigation of effects of metallocenic chirality upon antimalarial activity and cytotoxicity.

Synthesis, characterization and in vitro anti-Trypanosoma cruzi and anti-Mycobacterium tuberculosis evaluations of cyrhetrenyl and ferrocenyl thiosemicarbazones

Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents.

Targeting malaria parasite at the level of apicoplast: an update

The Many Ways by Which -GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations

The antimalarial ferroquine is an inhibitor of hepatitis C virus.

The antimalarial ferroquine: from bench to clinic

The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance