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List of works by David Bowtell

19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes

scientific article published on 09 September 2018

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

scientific article published on 06 December 2016

A binding motif for Siah ubiquitin ligase.

scholarly article

A c-Cbl Yeast Two Hybrid Screen Reveals Interactions with 14-3-3 Isoforms and Cytoskeletal Components ⬇️

scientific article published on November 7, 1997

A community-based model of rapid autopsy in end-stage cancer patients

scientific article published on 12 September 2016

A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival

scientific article published on 14 December 2015

A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment

scientific article published on 7 November 2011

A molecular diagnostic test for distinguishing lung adenocarcinoma from malignant mesothelioma using cells collected from pleural effusions.

scientific article

A role for common genomic variants in the assessment of familial breast cancer

scientific article published on 29 October 2012

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer

scientific article

AKT1 gene amplification as a biomarker of treatment response in ovarian cancer: mounting evidence of a therapeutic target

scientific article

ARID1A mutations in endometriosis-associated ovarian carcinomas

scientific article

Abstract 3276: A novel in vivo xenograft mouse model of human high-grade serous ovarian cancer, with clinical, molecular and functional annotation relevant for pre-clinical analysis

article

Acquired chemotherapy resistance in ovarian cancer.

scientific article published in November 2017

Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

scientific article

Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer

scientific article

Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer

scientific article

An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin

scientific article

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.

scientific article

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study

scientific article published on 30 July 2018

BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group

scientific article

Blood Worth Bottling: Circulating Tumor DNA as a Cancer Biomarker.

scientific article

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

scientific article

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

Commentary on "Epithelial-to-Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer".

scientific article

Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis

scientific article

Connecting patients, researchers and clinical genetics services: the experiences of participants in the Australian Ovarian Cancer Study (AOCS).

scientific article

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population

scientific article published on 10 September 2015

Copy number analysis identifies novel interactions between genomic loci in ovarian cancer

scientific article

Correction: The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".

scientific article published on 21 April 2017

Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.

scientific article published on 23 December 2013

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites.

scientific article

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

scientific article

Development and validation of a gene expression tumour classifier for cancer of unknown primary

scientific article published on 01 January 2015

Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE)

scientific article published on 17 June 2020

Differential expression of selected histone modifier genes in human solid cancers

scientific article published on 25 April 2006

Differentiating stage 1 epithelial ovarian cancer from benign ovarian tumours using a combination of tumour markers HE4, CA125, and CEA and patient's age

scientific article published on 13 March 2013

Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer

article

Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.

scientific article published on 12 October 2017

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

scientific article

Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation

scientific article published in March 2004

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

scientific article published on 10 September 2015

EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas

scientific article published on 23 June 2017

Efficient molecular subtype classification of high-grade serous ovarian cancer

scientific article published on 30 April 2015

Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer

scientific article published on 21 June 2017

Elucidation of the substrate binding site of Siah ubiquitin ligase

scientific journal article

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

scientific article published on 7 April 2015

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis

scientific article published on 26 August 2016

Erratum to: Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

scientific article published on 12 January 2017

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

scientific article

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

scientific article

Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia

scientific article

Generation and analysis of Siah2 mutant mice.

scientific article

Genes predisposed to DNA hypermethylation during acquired resistance to chemotherapy are identified in ovarian tumors by bivalent chromatin domains at initial diagnosis.

scientific article published on 16 January 2018

Genomewide gene expression analysis using cDNA microarrays

scientific article published on 01 January 2002

Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver

scientific article published on 14 October 2014

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer

scientific article published on 27 August 2015

Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer

scientific article

Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene

scientific article published on 3 March 2017

Germline whole exome sequencing of a family with appendiceal mucinous tumours presenting with pseudomyxoma peritonei

scientific article published on 01 May 2020

High levels of genomic aberrations in serous ovarian cancers are associated with better survival

scientific article

High resolution melting for mutation scanning of TP53 exons 5-8

scientific article

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer.

scientific article

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

scientific article

IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer

scientific article published on 22 February 2011

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

scientific article

Identification of novel therapeutic targets in microdissected clear cell ovarian cancers

scientific article (publication date: 2011)

Identifying Associations Between Genomic Alterations in Tumors

scientific article published on 01 January 2013

Inhibition of Siah ubiquitin ligase function.

scientific article

Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas

scientific article published on 03 February 2009

Integration of new or experimental treatment options and new approaches to clinical trials.

scientific article

International network of cancer genome projects

scientific article

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

scientific article

Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization

scientific article published on 21 February 2017

Long-term survival of patients with mismatch repair protein-deficient, high-stage ovarian clear cell carcinoma

scientific article published on 21 July 2016

Loss of heterozygosity: what is it good for?

scientific article published on August 2015

Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary

scientific article published on December 2013

Mechanisms and clinical implications of tumor heterogeneity and convergence on recurrent phenotypes.

scientific article

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.

scientific article

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

scientific article published in Nature Communications

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas.

scientific article published in January 2013

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

scientific article

Molecular medicine: a clinician's primer on microarrays.

scientific article published in September 2004

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

scientific article published on 19 October 2015

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

scientific journal article

Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

scientific article published on 10 June 2009

Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

scientific article published on 7 August 2015

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

scientific article published in March 2018

Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations

scientific article published on 30 April 2013

Normal p53 function in primary cells deficient for Siah genes.

scientific article

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome

scientific article

Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization

scientific article published in March 2005

Oncogenic pathway combinations predict clinical prognosis in gastric cancer.

scientific article published on 02 October 2009

Options available--from start to finish--for obtaining data from DNA microarrays II.

scientific article

Options available--from start to finish--for obtaining expression data by microarray.

scientific article

Osteopenia in Siah1a mutant mice.

scientific article

PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations

scientific article published on 27 January 2016

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

scientific article

Pericytes Promote Malignant Ovarian Cancer Progression in Mice and Predict Poor Prognosis in Serous Ovarian Cancer Patients.

scientific article published on 20 November 2015

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer

scientific article published on 16 June 2020

Pre-invasive ovarian mucinous tumors are characterized by CDKN2A and RAS pathway aberrations

scientific article published on 13 August 2012

Primary treatment patterns in women recruited to the Australian Ovarian Cancer Study.

scientific article published on 12 April 2012

Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.

scientific article

Processed pseudogenes acquired somatically during cancer development

scientific article published on 09 April 2014

Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome

scientific article

Profiling the cancer genome.

scientific article published on January 2010

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

scientific article

RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary.

scientific article

Reclassifying ovarian cancer: origins, subtypes and resistance to therapy

scientific article published on 12 April 2012

Reducing time to diagnosis does not improve outcomes for women with symptomatic ovarian cancer: a report from the Australian Ovarian Cancer Study Group.

scientific article

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

scientific article published on 28 July 2020

Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah

scientific article

Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer

scientific article published on 4 September 2013

Response rates to second-line platinum-based therapy in ovarian cancer patients challenge the clinical definition of platinum resistance

scientific article published on 26 May 2018

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

scientific article

Rethinking ovarian cancer: recommendations for improving outcomes

scientific article

Reversion of BRCA1/2 Germline Mutations Detected in Circulating Tumor DNA From Patients With High-Grade Serous Ovarian Cancer.

scientific article published on 13 February 2017

Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer.

scientific article published on May 2011

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer

scientific article

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

scientific article published on 6 June 2017

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.

scientific article published on 23 September 2016

Serous ovarian and primary peritoneal cancers: A comparative analysis of clinico-pathological features, molecular subtypes and treatment outcome

scientific article published on 18 July 2016

Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon.

scientific article published on 12 November 2007

Siah proteins: novel drug targets in the Ras and hypoxia pathways

scientific article

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

scientific article

Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.

scientific article

Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.

scientific article published on 6 May 2013

Siah2-deficient mice show impaired skin wound repair.

scientific article published on 29 April 2013

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

scientific article

Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis

scientific article

Stress-induced decrease in TRAF2 stability is mediated by Siah2

scientific article

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

scientific article published on 3 September 2013

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

scientific article

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

scientific article

The Australian Ovarian Cancer Study

The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity

scientific article

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene.

scientific article published on 14 February 2011

The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.

scientific article published on 25 October 2016

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".

scientific article

The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo

scientific article

The challenges of gene expression microarrays for the study of human cancer

scientific article

The changing view of high-grade serous ovarian cancer

scientific article

The experiences of research participants offered genetic test results as a result of taking part in a population based ovarian cancer research study?

article by MA Young et al published 2012 in Hereditary Cancer in Clinical Practice

The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

scientific article

The genesis and evolution of high-grade serous ovarian cancer ⬇️

scientific article published on October 14, 2010

The molecular origin and taxonomy of mucinous ovarian carcinoma

scientific article published on 02 September 2019

The responses of research participants and their next of kin to receiving feedback of genetic test results following participation in the Australian Ovarian Cancer Study

scientific article published on 28 February 2013

The retinoid anticancer signal: mechanisms of target gene regulation.

scientific article published on August 2005

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

scientific article

The ubiquitin ligase Siah2 regulates obesity-induced adipose tissue inflammation

scientific article

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

scholarly article

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice

scientific journal article

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

scientific article

Topological and Functional Discovery in a Gene Coexpression Meta-Network of Gastric Cancer

scientific article published in January 2006

Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach

scientific article published on 11 April 2017

Transducin-Like Enhancer of Split 3 (TLE3) expression is associated with taxane sensitivity in non-serous ovarian carcinoma in a three-cohort study

scientific article published on 12 March 2018

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

scientific article published on 15 December 2015

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

scientific article published on 21 February 2012

Whole-genome characterization of chemoresistant ovarian cancer

scientific article published in May 2015

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.

scientific article published in February 2005

p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study

scientific article published on 22 March 2023

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