List of works - Anthony V. Moorman

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

scientific article

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia.

scientific article published on 23 June 2014

A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin

scientific article published on 25 September 2008

A population-based cytogenetic study of adults with acute lymphoblastic leukemia

scientific article published on 06 November 2009

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.

scientific article published on 18 October 2012

Acute leukemia in children with Down's syndrome: the importance of population based study

scientific article published on 02 June 2008

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

scientific article

Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials

scientific article

Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion

scientific article published on 14 September 2020

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

scientific article published on 01 November 2003

Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.

scientific article

Amplification of the ABL gene in T-cell acute lymphoblastic leukemia

article

An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

scientific article

Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII study

scientific article published on 04 November 2009

Association of 17p loss with late-stage or refractory disease in hematologic malignancy.

scientific article

Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): a randomised controlled trial

scientific article published on 9 June 2014

Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

scientific article published in Nature Communications

BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia

scientific article published on 17 July 2012

Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome

scientific article published on 01 August 2005

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia

scientific article

Characterization of leukemias with ETV6-ABL1 fusion

scientific article published on 26 May 2016

Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia.

scientific article

Complex hypodiploidy in acute myeloid leukaemia: a United Kingdom Cancer Cytogenetics Group study.

scientific article published on December 1995

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

scientific article

Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements.

scientific article

Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.

scientific article

Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial

scientific article published on 24 November 2010

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

scientific article published on 29 July 2009

Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia

scientific article published on 01 April 2005

Does TP53 guard ALL genomes?

scientific article

ETV6/RUNX1 fusion at diagnosis and relapse: Some prognostic indications

article

Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial

scientific article

Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity

scientific article

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia.

scientific article

Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features ⬇️

scientific article published on March 18, 2013

Genetic variegation of clonal architecture and propagating cells in leukaemia

scientific article published on 15 December 2010

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia ⬇️

scientific article published on 9 April 2018

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

scientific article

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia ⬇️

scientific article published on April 28, 2011

Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.

scientific article published on 16 October 2008

High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome.

scientific article published on 19 December 2013

Hyperdiploidy with 49–65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome

scientific article published on 01 July 2013

IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome.

scientific article

IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia

scientific article

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

scientific article published on 25 November 2019

Immunophenotype and cytogenetic characteristics in the relationship between birth weight and childhood leukemia.

scientific article published on 16 June 2011

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial.

scientific article published on 3 July 2012

Incidence of childhood acute lymphoblastic leukaemia in Yorkshire, UK

scientific article published on 01 August 2001

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

scientific article published on 26 May 2016

International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.

scientific article published on 2 May 2018

Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study.

scientific article

Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle.

scientific article published in April 2007

Involvement of the MLL gene in T-lineage acute lymphoblastic leukemia

article

Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia?

scientific article published on 01 January 2004

Isochromosomes in acute lymphoblastic leukaemia: i(21q) is a significant finding

scientific article published on 01 September 1996

Karyotype and age in acute myeloid leukemia. Are they linked?

scientific article published in April 2001

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial

scientific article

Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor

scientific article published on 2 May 2013

MLL translocations with concurrent 3' deletions: interpretation of FISH results

scientific article published in November 2004

Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia.

scientific article

Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/ECOG2993.

scientific article published on 26 October 2009

Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.

scientific article published in May 2007

No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

scientific article published on 01 April 2005

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

scientific article published on 08 April 2014

Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia

scientific article published on 26 June 2003

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

scientific article published on 22 March 2012

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol

scientific article published on 15 January 2014

Outcome of central nervous system relapses in childhood acute lymphoblastic leukaemia--prospective open cohort analyses of the ALLR3 trial

scientific article

Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial

scientific article

Patients entered into MRC AML trials are biologically representative of the totality of the disease in the UK

scientific article published on 01 August 2002

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. ⬇️

scientific article

Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia

scientific article published in October 2000

Population-based demographic study of karyotypes in 1709 patients with adult acute myeloid leukemia

scientific article published on 01 March 2006

Probes for hidden hyperdiploidy in acute lymphoblastic leukaemia

scientific article published on 01 May 1996

Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21).

scientific article published on 9 November 2006

Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial

scientific article published on 19 April 2010

Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International

scientific article

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

scientific article

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

scientific article published on 12 April 2010

Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials

scientific article published on 01 December 2007

Sex ratios and the risks of haematological malignancies

scientific article published on 01 September 2002

Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups.

scientific article published on January 2002

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

scientific article

Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001.

scientific article

The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A ⬇️

scientific article

The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial

scientific article published on 24 January 2013

The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia ⬇️

scientific article published on March 20, 2012

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia

article

Time for ALL adults to catch up with the children

scientific article

Treating childhood acute lymphoblastic leukemia in Malawi

scientific article

Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

scientific article

UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia

scientific article

Unravelling the prognostic effect of IKZF1 deletions and IGH@-CRLF2 in adult acute lymphoblastic leukaemia.

scientific article published in October 2013

Validation of the United Kingdom copy-number alteration classifier in 3239 children with B-cell precursor ALL

scientific article published on 01 January 2019

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

scientific article

t(14;19)(q32;q13): A recurrent translocation in B-cell precursor acute lymphoblastic leukemia

scientific article published on 01 January 2004

t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

scientific article

List of works by Anthony V. Moorman

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia.

A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin

A population-based cytogenetic study of adults with acute lymphoblastic leukemia

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.

Acute leukemia in children with Down's syndrome: the importance of population based study

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials

Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.

Amplification of the ABL gene in T-cell acute lymphoblastic leukemia

An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII study

Association of 17p loss with late-stage or refractory disease in hematologic malignancy.

Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): a randomised controlled trial

Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia

Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia

Characterization of leukemias with ETV6-ABL1 fusion

Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia.

Complex hypodiploidy in acute myeloid leukaemia: a United Kingdom Cancer Cytogenetics Group study.

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements.

Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.

Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia

Does TP53 guard ALL genomes?

ETV6/RUNX1 fusion at diagnosis and relapse: Some prognostic indications

Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial

Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia.

Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features ⬇️

Genetic variegation of clonal architecture and propagating cells in leukaemia

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia ⬇️

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia ⬇️

Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.

High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome.

Hyperdiploidy with 49–65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome

IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome.

IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

Immunophenotype and cytogenetic characteristics in the relationship between birth weight and childhood leukemia.

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial.

Incidence of childhood acute lymphoblastic leukaemia in Yorkshire, UK

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.

Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study.

Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle.

Involvement of the MLL gene in T-lineage acute lymphoblastic leukemia

Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia?

Isochromosomes in acute lymphoblastic leukaemia: i(21q) is a significant finding

Karyotype and age in acute myeloid leukemia. Are they linked?

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial

Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor

MLL translocations with concurrent 3' deletions: interpretation of FISH results

Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia.

Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/ECOG2993.

Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.

No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol

Outcome of central nervous system relapses in childhood acute lymphoblastic leukaemia--prospective open cohort analyses of the ALLR3 trial

Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial

Patients entered into MRC AML trials are biologically representative of the totality of the disease in the UK

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. ⬇️

Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia

Population-based demographic study of karyotypes in 1709 patients with adult acute myeloid leukemia

Probes for hidden hyperdiploidy in acute lymphoblastic leukaemia

Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21).

Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial

Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.