Search filters

List of works by Alexander E. Gorbalenya

50 years of the International Committee on Taxonomy of Viruses: progress and prospects.

scientific article

A Human RNA Viral Cysteine Proteinase That Depends upon a Unique Zn2+-binding Finger Connecting the Two Domains of a Papain-like Fold

scientific article published in Journal of Biological Chemistry

A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae.

scientific article published in November 2003

A complex zinc finger controls the enzymatic activities of nidovirus helicases

scientific article published on January 2005

A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses

scientific article published on 01 March 1990

A planarian nidovirus expands the limits of RNA genome size

scholarly article published by Amir Saberi in 2018

A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus

scientific article

A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus.

scholarly article

ADP-ribose-1"-monophosphatase: a conserved coronavirus enzyme that is dispensable for viral replication in tissue culture

scientific article published on October 2005

Additional changes to taxonomy ratified in a special vote by the International Committee on Taxonomy of Viruses (October 2018)

scientific article published on 01 March 2019

Alphavirus nucleocapsid protein contains a putative coiled coil alpha-helix important for core assembly

scientific article

An insect picornavirus may have genome organization similar to that of caliciviruses

scientific article published in February 1992

Analysis of the functional significance of amino acid residues in the putative NTP-binding pattern of the poliovirus 2C protein

scientific article published on August 1, 1992

Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology

scientific article published on June 2012

Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs

scientific article

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive

scientific article published on 22 October 2015

Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins

scientific article published on 3 June 2015

Arterivirus subgenomic mRNA synthesis and virion biogenesis depend on the multifunctional nsp1 autoprotease.

scientific article published on 11 July 2007

Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease

scientific article published on 18 March 2009

Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017).

scientific article published on 22 April 2017

Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018).

scientific article

Cloning and sequence analysis of cDNA for a human homolog of eubacterial ATP-dependent Lon proteases.

scientific article

Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages

scientific article published on 15 June 2012

Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses ⬇️

scientific article published on September 1, 1992

Consensus statement: Virus taxonomy in the age of metagenomics

scientific article

Conservation of the putative methyltransferase domain: a hallmark of the 'Sindbis-like' supergroup of positive-strand RNA viruses

scientific article

Construction of the full local similarity map for two biopolymers

scientific article published in January 1993

Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity

scientific article published on 16 April 2008

Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

scientific article

Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold

scientific article

Design and validation of consensus-degenerate hybrid oligonucleotide primers for broad and sensitive detection of corona- and toroviruses

scientific article

Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient

scientific article published on 29 July 2010

Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis

scholarly article

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

scientific article published on 24 August 2015

Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes

scientific article published in September 2011

Domain Organization and Evolution of the Highly Divergent 5' Coding Region of Genomes of Arteriviruses, Including the Novel Possum Nidovirus

scientific article published on 4 January 2017

Editorial [Hot Topic: Workshop on the Definition of Protein Domains and their Likelihood of Crystallization (Guest Editors: Oliviero Carugo, Kristina Djinovic, Sasha Gorbalenya and Paul Tucker)]

article by Oliviero Carugo et al published 1 April 2007 in Current Protein and Peptide Science

Encephalomyocarditis virus-specific polypeptide p22 is involved in the processing of the viral precursor polypeptides ⬇️

scientific article published on December 1, 1979

Euprosterna elaeasa virus genome sequence and evolution of the Tetraviridae family: emergence of bipartite genomes and conservation of the VPg signal with the dsRNA Birnaviridae family

scientific article published on December 2009

Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication

scientific article

Evidence for functional protein interactions required for poliovirus RNA replication

scientific article published on June 2006

Evidence for functional significance of the permuted C motif in Co2+-stimulated RNA-dependent RNA polymerase of infectious bursal disease virus

scientific article

Expression, purification, and in vitro activity of an arterivirus main proteinase

scientific article published on 9 March 2006

From Stockholm to Malawi: recent developments in studying human polyomaviruses

scientific article published on 19 December 2012

Functional Characterization of the Cleavage Specificity of the Sapovirus Chymotrypsin-Like Protease

scientific article (publication date: August 2008)

Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization

scientific article

Genetics-based classification of filoviruses calls for expanded sampling of genomic sequences

scientific article published on 31 August 2012

Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans

scientific article

Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription.

scientific article published on 25 February 2010

How to recognise and deal with dubious virus sequences?

scientific article published on 13 February 2020

Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication

scientific article published on 24 January 2007

ICTV Virus Taxonomy Profile: Picornaviridae

scientific article published on 8 September 2017

Identification of protease and ADP-ribose 1''-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3.

scientific article published on March 2006

Identification of tolerated insertion sites in poliovirus non-structural proteins

scientific article published on 23 October 2010

Increasing the number of available ranks in virus taxonomy from five to ten and adopting the Baltimore classes as taxa at the basal rank

scholarly article by Alexander E Gorbalenya published in October 2018

Induction of intracellular membrane rearrangements by HAV proteins 2C and 2BC.

scientific article

Interspecific adaptation by binary choice at de novo polyomavirus T antigen site through accelerated codon-constrained Val-Ala toggling within an intrinsically disordered region

scientific article published on 22 April 2015

LAMPA, LArge Multidomain Protein Annotator, and its application to RNA virus polyproteins

scientific article published on 31 January 2020

Limited variation during circulation of a polyomavirus in the human population involves the COCO-VA toggling site of Middle and Alternative T-antigen(s).

scientific article published on 28 October 2015

Major genetic marker of nidoviruses encodes a replicative endoribonuclease

scholarly article

Mechanisms and enzymes involved in SARS coronavirus genome expression

scientific article

Mesoniviridae: a proposed new family in the order Nidovirales formed by a single species of mosquito-borne viruses

scientific article

Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group

scientific article

Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus

scientific article published on 25 September 2015

Molecular analysis of three Ljungan virus isolates reveals a new, close-to-root lineage of the Picornaviridae with a cluster of two unrelated 2A proteins

scientific article

Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autoprocessing

scientific article

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

scientific article published on 11 May 2016

Nidovirales: evolving the largest RNA virus genome

scientific article

No novel coronaviruses identified in a large collection of human nasopharyngeal specimens using family-wide CODEHOP-based primers

scientific article

Non-canonical inteins.

scientific article

Norwalk virus N-terminal nonstructural protein is associated with disassembly of the Golgi complex in transfected cells

scientific article published on May 2004

One more conserved sequence motif in helicases ⬇️

scientific article published on August 11, 1988

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

scientific article

Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.

scientific article published on 28 January 2009

Organization and evolution of bacterial and bacteriophage primase-helicase systems

scientific article published on April 1, 1992

PCR assays for detection of human astroviruses: In silico evaluation and design, and in vitro application to samples collected from patients in the Netherlands

scientific article published on 13 September 2018

Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates

scientific article

Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses

scientific article published on 25 January 2012

Permutation of the active site of putative RNA-dependent RNA polymerase in a newly identified species of plant alpha-like virus.

scientific article

Picornavirales, a proposed order of positive-sense single-stranded RNA viruses with a pseudo-T = 3 virion architecture

scientific article

Picornavirus non-structural proteins as targets for new anti-virals with broad activity

scientific article

Poliovirus-encoded proteinase 3C: a possible evolutionary link between cellular serine and cysteine proteinase families

scientific article

Practical application of bioinformatics by the multidisciplinary VIZIER consortium

scientific article published on 11 February 2010

Proteolytic activity of the nonstructural polypeptide p22 of encephalomyocarditis virus ⬇️

scientific article published on February 27, 1981

Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7.

scientific article published on December 2006

RNA-binding properties of nonstructural polypeptide G of encephalomyocarditis virus ⬇️

scientific article

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2015).

scientific article

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016).

scientific article

SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro

scientific article

SNAD: Sequence Name Annotation-based Designer

scientific article

Severe acute respiratory syndrome coronavirus phylogeny: toward consensus

scientific article

Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group

scientific article published on 11 February 2020

Site-directed mutagenesis of La protease

scientific article published on 01 August 1991

Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle.

scientific article

Sobemovirus genome appears to encode a serine protease related to cysteine proteases of picornaviruses

scientific article published on 01 August 1988

Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19

controversial scientific article on COVID-19 origins published on 19 February 2020

Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93

scientific article

Structural and functional characterization of sapovirus RNA-dependent RNA polymerase

scientific article published on 22 November 2006

Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus

scientific article published on 02 May 2019

Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase ⬇️

scientific article

Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole

scientific article

Structure of the C-terminal domain of nsp4 from feline coronavirus

scientific article

Structure of the X (ADRP) domain of nsp3 from feline coronavirus

scientific article

Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relationship to positive strand RNA viral polymerases

scientific article

Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein

scientific article published on 14 October 2005

The "Bridge" in the Epstein-Barr virus alkaline exonuclease protein BGLF5 contributes to shutoff activity during productive infection

scientific article

The 2C putative helicase of echovirus 30 adopts a hexameric ring-shaped structure.

scientific article

The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs

scientific article

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

scientific article (publication date: July 2009)

The NS5A protein of hepatitis C virus is a zinc metalloprotein

scientific article published on 31 August 2004

The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond.

scientific article

The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase ⬇️

scientific article published on February 1, 1991

The footprint of genome architecture in the largest genome expansion in RNA viruses

scientific article

The in vitro RNA synthesizing activity of the isolated arterivirus replication/transcription complex is dependent on a host factor

scientific article

The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage

scientific article published in November 2002

The predicted metal-binding region of the arterivirus helicase protein is involved in subgenomic mRNA synthesis, genome replication, and virion biogenesis.

scientific article

The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.

scholarly article

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

scientific article published on 2 March 2020

Toward genetics-based virus taxonomy: comparative analysis of a genetics-based classification and the taxonomy of picornaviruses

scientific article (publication date: April 2012)

Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control.

scientific article

Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage

scientific article (publication date: 29 August 2003)

VP1 of infectious bursal disease virus is an RNA-dependent RNA polymerase

scientific article

Viral cysteine proteinases

scientific article published on 01 January 1996

What we know but do not understand about nidovirus helicases

scientific article

Paulina is supported by:

About Paulina

Help