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List of works by Costas A Lyssiotis

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

scientific article published on 14 April 2013

A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth

scientific article published on 28 November 2019

A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling.

scientific article

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

scientific article published on 23 September 2009

A guide to interrogating immunometabolism

scientific article published in 2021

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics

scientific article published on 09 July 2019

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

scientific article published on 30 March 2016

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

scientific article published on 30 October 2017

ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer

scientific article published in 2021

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

scientific article published on 01 April 2019

Acetate fuels the cancer engine.

scientific article

Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer

scientific article published on 7 June 2016

Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.

scientific article

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1

publication published on 28 May 2021

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma

scientific article published on 25 June 2019

Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

scientific article published on 01 June 2020

Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors

scientific article published on 12 November 2018

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

scientific article published on 02 September 2020

Chemical control of stem cell fate and developmental potential

scientific article published on January 2011

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

scientific article published on 04 March 2019

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

scientific article published on 22 August 2012

Cysteine depletion induces pancreatic tumor ferroptosis in mice

scientific article published on 01 April 2020

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma

scientific article published on 27 April 2018

Dysregulated metabolism contributes to oncogenesis

scientific article

Emerging concepts: linking hypoxic signaling and cancer metabolism.

scientific article published on 3 May 2012

Emerging concepts: linking hypoxic signaling and cancer metabolism.

scientific article published on 21 June 2012

Emerging roles for SIRT5 in metabolism and cancer

scientific article

Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

scientific article published on January 2017

Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes

scientific article published on 19 March 2020

Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function

scientific article published on 25 March 2019

Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

scientific article published on 05 October 2016

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS

scientific article published on 01 February 2019

FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS

scientific article published on 01 April 2021

Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation.

scientific article published on 22 April 2018

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

scientific article published on 06 September 2013

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

scientific article published on 11 August 2021

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

scientific article published on 06 December 2016

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

scientific article published on 27 March 2013

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

scientific article published on 18 April 2016

High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions

scientific article published on 29 May 2020

Human Norovirus Triggers Primary B Cell Immune Activation <i>In Vitro</i>

scientific article published on 11 April 2022

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells

scientific article published on 18 June 2019

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

scientific article published on 01 February 2019

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

scientific article published in February 2016

Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.

scientific article published on 27 February 2017

Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress

scientific article published on 18 November 2019

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

scientific article published in September 2017

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

scientific article published in July 2017

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

scientific article published on 28 February 2019

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

scientific article published on 26 May 2021

Menin regulates the serine biosynthetic pathway in Ewing sarcoma.

scientific article published on 19 April 2018

Meta-analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics: Supplemental Tables

scholarly article published 2 January 2019

Metabolic Interactions in the Tumor Microenvironment

scientific article

Metabolic Regulation of Redox Balance in Cancer

scientific article published on 08 July 2019

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

scientific article

Metabolic regulation of ferroptosis in the tumor microenvironment

scientific article published in 2022

Metabolic syndrome: F stands for fructose and fat.

scientific article

Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors

scientific article published on 01 March 2019

Metabolism and Epigenetics of Pancreatic Cancer Stem Cells

scientific article published on 28 September 2018

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant KRAS-Driven Cancers

scientific article published on 3 October 2016

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

scientific article published on 25 January 2018

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

scientific article published on 21 November 2019

New tricks for an old drug

article

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

scientific article published on 01 June 2019

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

scientific article

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

scientific article published in Nature Communications

Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.

scientific article published on 30 October 2017

Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells

scientific article

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

scientific article published on 10 June 2013

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

scientific article published on 10 August 2016

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

scientific article published on January 2016

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

scientific article published on 08 July 2016

Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation

scientific article published on 02 May 2013

Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation

scientific article

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

scientific article published on 30 July 2020

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

scientific article published on 07 January 2020

Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer

scientific article published on 04 November 2019

SIRT6 puts cancer metabolism in the driver's seat.

scientific article

TUMOR CROSSTALK NETWORKS PROMOTE GROWTH AND SUPPORT IMMUNE EVASION IN PANCREATIC CANCER.

scientific article published on 15 March 2018

Targeting metabolic scavenging in pancreatic cancer

scientific article published on 28 October 2013

The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

scientific article published on 01 May 2018

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

scientific article published on 02 January 2020

Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.

scientific article published on 3 October 2015

When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade.

scientific article published in December 2017

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