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List of works by Claudio Sette

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.

scientific article published on 09 August 2013

Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development

scientific article

Activation of the mitogen-activated protein kinase ERK1 during meiotic progression of mouse pachytene spermatocytes

scientific article published on 01 November 1999

Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells.

scientific article published on 9 November 2017

Alternative splicing and cell survival: from tissue homeostasis to disease

scientific article

Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.

scientific article

Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68

scientific article

Alternative splicing: role in cancer development and progression.

scientific article published on 20 November 2013

Analysis of the gene expression profile of mouse male meiotic germ cells

scientific article

Androgen Receptor signaling promotes the neural progenitor cell pool in the developing cortex

scientific article published on 21 September 2020

Antagonists of IL-1R: a patent evaluation (WO2012122985).

scientific article published on 29 May 2013

Anti-proliferative effect of a triazole derivative (ST1959) on LNCaP human prostate cancer cells through down-regulation of cyclin and androgen receptor expression.

scientific article published on January 2011

Combinatorial control of Spo11 alternative splicing by modulation of RNA polymerase II dynamics and splicing factor recruitment during meiosis

scientific article published on 17 April 2020

Combined treatment with the histone deacetylase inhibitor LBH589 and a splice-switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells

scientific article published on 06 December 2019

Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis

scientific article published on 26 July 2018

Differential contribution of the MTOR and MNK pathways to the regulation of mRNA translation in meiotic and postmeiotic mouse male germ cells.

scientific article published on 23 June 2010

Drug resistance in pancreatic cancer: New player caught in act

scientific article published on 11 February 2019

Dynamic expression of the RNA-binding protein Sam68 during mouse pre-implantation development

scientific article published on 2 February 2008

Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis

scientific article

EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation

scientific article published on 01 April 2022

Expression of a truncated form of KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity

scientific article published on 3 July 2010

Expression of stemness markers in mouse parthenogenetic-diploid blastocysts is influenced by slight variation of activation protocol adopted

scientific article published on 8 April 2010

Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients.

scientific article

Expression, phosphorylation, and mRNA-binding of heterogeneous nuclear ribonucleoprotein K in Xenopus oocytes, eggs, and early embryos

scientific article published in January 2008

FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription

scientific article

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation.

scientific article

Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes

scientific journal article

Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway.

scientific article

Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin.

scientific article

Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse

scientific article published on 18 June 2008

Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene

scientific article

Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells

scientific article

Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas

scientific article

Involvement of phospholipase Cgamma1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa.

scientific article

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.

scientific article published on 03 August 2015

Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells.

scientific article published on 9 September 2013

PATZ1 gene has a critical role in the spermatogenesis and testicular tumours

scientific journal article

Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas.

scientific article

Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B

scientific article published on 08 March 2005

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients.

scientific article published on 25 August 2010

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

scientific article

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

scientific article published on 22 September 2008

Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes

scientific journal article

Phosphorylation-mediated regulation of alternative splicing in cancer

scientific article

Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound

scientific article published on 04 June 2007

Post-transcriptional control of gene expression in mouse early embryo development: a view from the tip of the iceberg

scientific article published on 06 April 2011

Rational design of MyD88 inhibitors--new pathways to inflammatory control: an interview with Dr. Claudio Sette by Helene F. Rosenberg

scientific article published on 3 August 2007

Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5' splice site selection

scientific article published on 7 October 2014

Regulation of cAMP-phosphodiesterases by phosphatidic acid binding

scientific article published on 01 January 1999

Role of RNA-binding proteins in mammalian spermatogenesis

scientific article published on 05 March 2009

SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophy

scientific article

Sam68 marks the transcriptionally active stages of spermatogenesis and modulates alternative splicing in male germ cells

scientific article

Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

scientific article

Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene.

scientific article

Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis

scientific article

Sam68: a new STAR in the male fertility firmament

scientific article published on 29 October 2009

Signalling pathways passing Src in pancreatic endocrine tumours: relevance for possible combined targeted therapies.

scientific article published on 21 March 2012

Spinal muscular atrophy: A new player joins the battle forSMN2exon 7 splicing ⬇️

scientific article published on October 26, 2010

Splicing Regulation: A Molecular Device to Enhance Cancer Cell Adaptation

scientific article (publication date: 2015)

Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells.

scientific article published on March 2007

Src kinase activity coordinates cell adhesion and spreading with activation of mammalian target of rapamycin in pancreatic endocrine tumour cells

scientific article published on 30 August 2011

TLR stimulation of prostate tumor cells induces chemokine-mediated recruitment of specific immune cell types.

scientific article

Targeting TLR/IL-1R signalling in human diseases.

scientific article published on 08 April 2010

Targeting the Toll-like receptor/interleukin 1 receptor pathway in human diseases: rational design of MyD88 inhibitors.

scientific article published on 13 March 2013

The RNA binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in Pancreatic Ductal Adenocarcinoma

scientific article published on 07 November 2020

The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs

scientific article

The RNA binding protein Sam68 controls T helper 1 differentiation and anti-mycobacterial response through modulation of miR-29

scientific article published on 26 September 2018

The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator ⬇️

scientific article published on October 7, 2011

The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells

scientific article

The RNA-binding protein Sam68 is a multifunctional player in human cancer

scientific article (publication date: August 2011)

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

scientific article

The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding. Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site

scientific article published on 01 October 2000

The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival

scientific article published on 24 December 2013

The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability

scientific article published on 15 April 2015

The mechanism of docosahexaenoic acid-induced phospholipase D activation in human lymphocytes involves exclusion of the enzyme from lipid rafts.

scientific article

The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes

scientific article published on 12 October 2005

The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells

scientific article published on 20 December 2021

The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis

scientific article published on 12 June 2015

The role of SRC family kinases in neuroendocrine tumors

scientific article published on 27 February 2012

The splicing landscape is globally reprogrammed during male meiosis

scientific article published on 12 September 2013

The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

scientific article

The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis

scientific article

The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells

scientific article published on 2 September 2013

Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase

scientific article

Transcriptome programs involved in the development and structure of the cerebellum

Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells

scientific article

cAMP-dependent induction of PDE5 expression in murine neuroblastoma cell differentiation

scientific article published on 01 March 1999

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