List of works - Martin Böttcher

A novel immunoregulatory function of beta-2-microglobulin as a promoter of myeloid derived suppressor cell induction

scientific article published on 11 January 2019

CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D.

scientific article published on 23 December 2016

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization.

scientific article published on 26 March 2018

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

scientific article published on 21 February 2019

Exploitable metabolic dependencies in MLL-ENL-induced leukemia

scientific article published on 01 August 2020

IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner

scientific article published on 7 February 2018

Impact of Nrf2 expression in reconstituting T-cells of allogeneic hematopoietic stem cell transplanted patients

scientific article published on 23 July 2020

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.

scientific article published on 22 November 2017

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress.

scientific article published on 28 October 2010

Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation

scientific article published on 24 January 2019

Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis

scientific article published on 4 September 2017

Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway

scientific article published on 28 March 2018

Mesenchymal Stromal Cells Disrupt mTOR-Signaling and Aerobic Glycolysis During T-Cell Activation

scientific article published on 20 October 2015

Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia

scientific article published on 01 July 2021

PD-L1/PD-1: new kid on the "immune metabolic" block.

scientific article published on 5 September 2017

Palmitoylated proteins on AML-derived extracellular vesicles promote myeloid-derived suppressor cell differentiation via TLR2/Akt/mTOR signaling

scientific article published on 30 June 2020

Polyol pathway links glucose metabolism to the aggressiveness of cancer cells

scientific article published on 17 January 2018

Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3

scientific article published on 10 August 2009

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.

scientific article

Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA

scientific article published on 11 November 2019

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.

scientific article published on 4 January 2018

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

scientific article published on March 2015

The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia.

scientific article published on August 2016

List of works by Martin Böttcher