List of works by Miguel López

"Mens sana in corpore sano": exercise and hypothalamic ER stress.

scientific article

3-Iodothyronamine Induces Tail Vasodilation Through Central Action in Male Mice

scientific article published on 23 March 2017

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.

scientific article published on 10 August 2016

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages.

scientific article

A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat

scientific journal article

ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

scientific article published on 05 May 2020

AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction

scientific article published on 04 December 2020

AMPK Wars: the VMH Strikes Back, Return of the PVH.

scientific article published on 5 February 2018

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

scientific article published on 31 August 2015

AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin

scientific article published on 21 August 2020

AMPK: a metabolic gauge regulating whole-body energy homeostasis

scientific article

AMP‐activated protein kinase: ‘a cup of tea’ against cholesterol‐induced neurotoxicity ⬇️

scientific article published on December 1, 2010

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance

scientific article (publication date: November 2006)

Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation

scientific article published on 16 May 2020

Acute but not chronic activation of brain glucagon-like peptide-1 receptors enhances glucose-stimulated insulin secretion in mice

scientific article published on 11 May 2015

Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat.

scientific article published on 12 July 2011

Acute stimulation of brain mu opioid receptors inhibits glucose-stimulated insulin secretion via sympathetic innervation

scientific article

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity

scientific article

Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner.

scientific article published in January 2010

Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence

scientific article published on 16 November 2018

Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function

scientific article published on 11 September 2018

Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus

scientific article published in February 2003

Analyzing AMPK Function in the Hypothalamus

scientific article published on 01 January 2018

Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery.

scientific article published on 9 March 2017

BAT Expansion: A Panacea against Obesity? Lessons from LKB1.

scientific article

BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions

scientific article

Brain Ceramide Metabolism in the Control of Energy Balance

scientific article published on 12 October 2017

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

scientific article published in September 2007

Brain lipogenesis and regulation of energy metabolism

scientific article published on July 2008

Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects

scientific article published on 11 May 2020

Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability

scientific article

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.

scientific article

Caffeine treatment regulates neuropeptide S system expression in the rat brain.

scientific article published on 19 October 2006

Cellular energy sensors: AMPK and beyond.

scientific article published on 18 November 2014

Central Oxytocin and Energy Balance: More Than Feelings.

scientific article published in September 2017

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance

scientific article published on 02 October 2014

Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion

scientific article

Central leptin and autonomic regulation: A melanocortin business

scientific article published on 9 January 2018

Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin

scientific article published on 28 April 2013

Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways

scientific article published on 6 November 2012

Central nicotine induces browning through hypothalamic κ opioid receptor

scientific article published on 06 September 2019

Central regulation of energy metabolism by estrogens

scientific article published on 23 May 2018

Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion

scientific article published on 22 May 2008

Ceramide sensing in the hippocampus: The lipostatic theory and Ockham's razor

scientific article

Come to Where Insulin Resistance Is, Come to AMPK Country.

scientific article

Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

scientific article published on 03 March 2020

Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance.

scientific article published on November 2016

Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes).

scientific article published on 3 August 2009

Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity.

scientific article published on 17 January 2017

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

scientific article published on 31 October 2019

Differential Role of Hypothalamic AMPKα Isoforms in Fish: an Evolutive Perspective

scientific article published on 20 November 2018

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity

scientific article published in May 2009

EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?

scientific article

Effects of neonatal programming on hypothalamic mechanisms controlling energy balance.

scientific article published on 02 August 2013

Energy balance regulation by thyroid hormones at central level

scientific article published on 23 May 2013

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

scientific article published on 10 February 2016

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

scientific article published on 01 October 2018

Estradiol Regulation of Brown Adipose Tissue Thermogenesis.

scientific article published in January 2017

Estradiol and brown fat.

scientific article

Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment?

scientific article published on 25 March 2017

Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK

scientific article

Estrogens and the control of energy homeostasis: a brain perspective

scientific article published on 27 June 2015

Expression of neuropeptide W in rat stomach mucosa: regulation by nutritional status, glucocorticoids and thyroid hormones.

scientific article published on 4 September 2007

Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.

scientific article

Ferritin regulates organismal energy balance and thermogenesis

scientific article published on 21 March 2019

Firing up brown fat with brain amylin

scientific article published in July 2013

GPR55 and the regulation of glucose homeostasis.

scientific article

Gastrointestinal peptides controlling body weight homeostasis.

scientific article

Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

article

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.

scientific article

Ghrelin and lipid metabolism: key partners in energy balance

scientific article published on 15 February 2011

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

scientific article published on 24 March 2010

Ghrelin requires p53 to stimulate lipid storage in fat and liver

scientific article published on 5 July 2013

Ghrelin.

scientific article

Glucagon, GLP-1 and Thermogenesis

scientific article published on 13 July 2019

Glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets

scientific article published on 6 April 2016

HYPOTHesizing about central comBAT against obesity

scientific article published on 16 December 2019

Hepatic p63 regulates steatosis via IKKβ/ER stress

scientific article

Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet

scientific article

Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

scientific article published on 18 February 2012

Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance

scientific article published on September 2011

Hypothalamic AMPK and energy balance

scientific article published on 30 July 2018

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

scientific article

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

scientific article

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

scientific article published on 20 May 2016

Hypothalamic AMPKα2 regulates liver energy metabolism in rainbow trout through vagal innervation

scientific article published on 06 November 2019

Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues

scientific article published on 12 July 2020

Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance.

scientific article published on 22 October 2015

Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat.

scientific article published on 7 January 2015

Hypothalamic GRP78, a new target against obesity?

scientific article published on 20 December 2017

Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP

scientific article

Hypothalamic Leptin Resistance: From BBB to BBSome.

scientific article

Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance.

scientific article

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

scientific article published on 14 March 2013

Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins

scientific article published on 17 May 2011

Hypothalamic dopamine signaling regulates brown fat thermogenesis

scientific article published on 19 August 2019

Hypothalamic effects of thyroid hormones on metabolism.

scientific article published on 25 April 2014

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

scientific article published in May 2008

Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress.

scientific article published on 7 July 2016

Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin.

scientific article published in August 2003

Hypothalamic lipids and the regulation of energy homeostasis.

scientific article published on 03 April 2009

Hypothalamic lipotoxicity and the metabolic syndrome

scientific article published on 29 September 2009

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.

scientific article published on 17 February 2012

Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin

scientific article

Hypothalamic mTOR: the rookie energy sensor.

scientific article published on January 2014

Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice.

scientific article published on 3 May 2017

Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin

scientific article

Hypothalamic-autonomic control of energy homeostasis

scientific article published on 19 June 2015

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT.

scientific article

Impaired Ca2+ handling in resistance arteries from genetically obese Zucker rats: Role of the PI3K, ERK1/2 and PKC signaling pathways.

scientific article

Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation

article

Irisin, two years later

scientific article

Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression.

scientific article

Lack of Ovarian Secretions Reverts the Anabolic Action of Olanzapine in Female Rats

scientific article published on 14 August 2017

Lipopolysaccharide (LPS)-induced septic shock causes profound changes in myocardial energy metabolites in pigs

scientific article published on 25 September 2018

Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure.

scientific article

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

scientific article published on 11 January 2006

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

scientific article published on 16 September 2019

Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.

scientific article published on 27 November 2017

Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

article published in the Proceedings of the National Academy of Sciences of the United States of America

Molecular mechanisms of appetite and obesity: a role for brain AMPK.

scientific article

Myostatin expression is regulated by underfeeding and neonatal programming in rats.

scientific article published on 9 June 2012

Neuromedin s as novel putative regulator of luteinizing hormone secretion.

scientific article

Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus

scientific article published on 01 January 2002

New insights in ghrelin orexigenic effect

scientific article published on 05 July 2010

Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats

scientific article published on 11 February 2014

Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase

scientific article published on 7 February 2012

Nicotine treatment regulates neuropeptide S system expression in the rat brain.

scientific article

Nicotine' actions on energy balance: Friend or foe?

scientific article published on 25 September 2020

Obesity Paradox in Ischemic Stroke: Clinical and Molecular Insights

scientific article published on 13 April 2019

Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects.

scientific article

Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats.

scientific article published on 19 August 2011

Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation

scientific article

Oral pharmacological activation of hypothalamic guanylate cyclase 2C receptor stimulates brown fat thermogenesis to reduce body weight

scientific article published on 17 January 2020

Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis.

scientific article published on 5 February 2004

Orexin expression is regulated by alpha-melanocyte-stimulating hormone

scientific article published on September 2007

Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus

scientific article

Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis

scientific article published on 21 September 2009

Orexins (hypocretins) and energy balance: More than feeding.

scientific article published on 23 July 2015

Orexins/Hypocretins: Key Regulators of Energy Homeostasis

scientific article published on 10 December 2019

Peripheral tissue-brain interactions in the regulation of food intake

scientific article published on February 2007

Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice

scientific article published on 16 May 2016

Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.

scientific article

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.

scientific article published on 15 December 2017

Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats

scientific article

Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status.

scientific article

Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids

scientific article published in August 2005

Recent Updates on Obesity Treatments: Available Drugs and Future Directions

scientific article published on 29 April 2020

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

scientific article

Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors.

scientific article published on 27 December 2013

Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency

scientific article published on 03 March 2014

Regulation of lipid metabolism by energy availability: a role for the central nervous system.

scientific article published on 21 October 2009

Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue

scientific article published on 25 October 2011

Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue.

scientific article published on 26 May 2009

Review of novel aspects of the regulation of ghrelin secretion

scientific article published on January 2014

Role of ghrelin in reproduction.

scientific article published on March 2007

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

scientific article published on 13 August 2018

Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue

scientific article published on 07 April 2017

Similarities between acylcarnitine profiles in large for gestational age newborns and obesity

scientific article published on 24 November 2017

Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA.

scientific article published in May 2006

Temperature but not leptin prevents semi-starvation induced hyperactivity in rats: implications for anorexia nervosa treatment

scientific article published on 24 March 2020

The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition, and Cognitive Function

scientific article published on 7 June 2017

The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction.

scientific article

The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats.

scientific article

The brain and brown fat

scientific article

The cellular and molecular bases of leptin and ghrelin resistance in obesity

scientific article

The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin

scientific article

The endocannabinoid system: role in glucose and energy metabolism

scientific article published on 14 April 2009

The kallikrein-kinin pathway as a mechanism for auto-control of brown adipose tissue activity

scientific article published on 01 May 2020

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

scientific article published on 4 September 2009

The opioid system and food intake: homeostatic and hedonic mechanisms

scientific article published on 19 April 2012

The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis.

scientific article published on 16 July 2013

Thyroid hormones induce browning of white fat ⬇️

scientific article published on 02 December 2016

Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus

scientific article published in October 2002

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

scientific article published on 01 June 2019

Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis

scientific article published in July 2005

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

scientific article

UCP1 and T3: A key "(un)couple" in energy balance

scientific article published on 5 August 2016

Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways

scientific article

Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice

scientific article published on 30 March 2019

Using brown adipose tissue to treat obesity - the central issue.

scientific article published on 24 May 2011

Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status.

scientific article published in August 2009

What is the real relevance of endogenous ghrelin?

scientific article published on 20 May 2015

dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe

scientific article published in 2024

mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol

scientific article published on 18 June 2018

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

scientific article published in Nature Communications

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