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List of works by Mark H. Wilcox

A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption ⬇️

scientific article published on 13 June 2016

A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of Intravenous Iclaprim Vs Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed to be Due to Gram-Positiv ⬇️

scientific article published on 21 December 2017

A Phase 3, Randomized, double-blind, multicenter study to EValuate the safety and efficacy of intravenous Iclaprim versus Vancomycin for the trEatment of acute bacterial skin and skin structure infections suspected or confirmed to be due to Gram-pos ⬇️

scientific article published on 12 March 2018

A Phase II Randomized, Double-blind, Multicenter Study to Evaluate Efficacy and Safety of Intravenous Iclaprim Versus Vancomycin for the Treatment of Nosocomial Pneumonia Suspected or Confirmed to be Due to Gram-positive Pathogens ⬇️

scientific article

A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated PCR Ribotype 078

scientific article published on 12 March 2019

A pilot study of rapid benchtop sequencing of Staphylococcus aureus and Clostridium difficile for outbreak detection and surveillance

scientific article (publication date: 2012)

A role for tetracycline selection in the evolution ofClostridium difficilePCR-ribotype 078

Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model

scientific article

An Enhanced DNA Fingerprinting Service To Investigate Potential Clostridium difficile Infection Case Clusters Sharing the Same PCR Ribotype ⬇️

scientific article published on September 28, 2011

An In Vitro Model of the Human Colon: Studies of Intestinal Biofilms and Clostridium difficile Infection ⬇️

scientific article published on January 2016

Antibiotic prescribing as a risk factor for MRSA.

scientific article

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe

scientific article published on 02 December 2019

Antibiotic strategies in the era of multidrug resistance ⬇️

scientific article

Antibiotic therapy and Clostridium difficile infection - primum non nocere - first do no harm ⬇️

scientific article

Antibodies for treatment of Clostridium difficile infection

scientific article published on 30 April 2014

Antimicrobial activity of LFF571 and three treatment agents against Clostridium difficile isolates collected for a pan-European survey in 2008: clinical and therapeutic implications ⬇️

scientific article published on February 18, 2013

Antimicrobial-resistant pathogens in animals and man: prescribing, practices and policies

scientific article

Are methicillin-resistant Staphylococcus aureus that produce Panton-Valentine leucocidin (PVL) found among residents of care homes?

scientific article published on 27 August 2008

Assessment of best single sample for finding chlamydia in women with and without symptoms: a diagnostic test study ⬇️

scientific article published on December 12, 2012

Assessment of self taken swabs versus clinician taken swab cultures for diagnosing gonorrhoea in women: single centre, diagnostic accuracy study ⬇️

scientific article published on December 12, 2012

Association of Fidaxomicin with C. difficile Spores: Effects of Persistence on Subsequent Spore Recovery, Outgrowth and Toxin Production ⬇️

scientific article

Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection ⬇️

scientific article published on January 2017

CANVAS 1: the first Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections

scientific article published on November 2010

CANVAS 2: the second Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections

scientific article published on November 2010

Can rapid integrated polymerase chain reaction-based diagnostics for gastrointestinal pathogens improve routine hospital infection control practice? A diagnostic study

scientific article

Caution is warranted in using cephamycin antibiotics against recurrent Clostridioides difficile infection

scientific article published on 27 January 2020

Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing ⬇️

scientific article

Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production

scientific article published on 25 September 2009

Clarifying the management of Clostridium difficile infection ⬇️

scientific article published on 19 November 2015

Clinical Clostridium difficile: clonality and pathogenicity locus diversity

scientific article

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

article

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).

scientific article published in March 2018

Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA).

scientific article

Clostridium difficile in England: can we stop washing our hands? - Authors' reply ⬇️

scientific article published in May 2017

Clostridium difficile infection in Europe: a hospital-based survey

scientific article published in The Lancet

Clostridium difficile infection: epidemiology, diagnosis and understanding transmission ⬇️

scientific article published on 9 March 2016

Clostridium difficile mixed infection and reinfection

scientific article published on 9 November 2011

Clostridium difficile ribotype 126 in southern Taiwan: a cluster of three symptomatic cases

scientific article published on 21 June 2014

Clostridium difficile trehalose metabolism variants are common and not associated with adverse patient outcomes when variably present in the same lineage

scientific article

Clostridium difficile: Investigating Transmission Patterns Between Infected and Colonized Patients Using Whole Genome Sequencing ⬇️

article

Clostridium difficile: biological therapies

scientific article published on October 2013

Clostridium difficile: changing epidemiology and new treatment options

scientific article

Co-amoxiclav induces proliferation and cytotoxin production of Clostridium difficile ribotype 027 in a human gut model

scientific article published on 25 January 2012

Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model

scientific article published on 4 September 2008

Comparison of planktonic and biofilm-associated communities of Clostridium difficile and indigenous gut microbiota in a triple-stage chemostat gut model

scientific article

Comparison of the 2010 and 2017 Infectious Diseases Society of America guidelines on the diagnosis and treatment of Clostridium difficile infection ⬇️

Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

scientific article

Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study

scientific article

Correlation between enterococcal biofilm formation in vitro and medical-device-related infection potential in vivo

scientific article published in July 2003

Covert dissemination of carbapenemase-producing Klebsiella pneumoniae (KPC) in a successfully controlled outbreak: long- and short-read whole-genome sequencing demonstrate multiple genetic modes of transmission. ⬇️

scientific article published on 7 August 2017

Decreased effectiveness of metronidazole for the treatment of Clostridium difficile infection?

scientific article published in July 2008

Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents

scientific article

Descriptive study of intravenous immunoglobulin for the treatment of recurrent Clostridium difficile diarrhoea

scientific article published on 8 April 2004

Development and validation of a chemostat gut model to study both planktonic and biofilm modes of growth of Clostridium difficile and human microbiota ⬇️

scientific article

Diagnosis of Clostridium difficile-associated diarrhea and odor

scientific article

Diagnostic pitfalls in Clostridium difficile infection

scientific article

Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection

scientific article published on 03 September 2013

Diverse sources of C. difficile infection identified on whole-genome sequencing

scientific article published on September 2013

Diverse temperate bacteriophage carriage in Clostridium difficile 027 strains ⬇️

scientific article

Diversity of Clostridium difficile PCR ribotypes in Europe: results from the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID), 2012 and 2013. ⬇️

scientific article published on July 2016

Each lumen is a potential source of central venous catheter-related bloodstream infection

scientific article published in June 2003

Editorial Commentary: Critically Ill Patients With Clostridium difficile Infection: Are 2 Antibiotics Better Than One?

scientific article published on 29 May 2015

Editorial Commentary: the trials and tribulations of treating Clostridium difficile infection-one step backward, one step forward, but still progress

scientific article published on 5 May 2014

Effect of metronidazole on growth and toxin production by epidemic Clostridium difficile PCR ribotypes 001 and 027 in a human gut model

scientific article published on 5 May 2007

Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut.

scientific article published on 29 May 2003

Effects of control interventions on Clostridium difficile infection in England: an observational study ⬇️

scientific article published on 24 January 2017

Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model

scientific article published on 18 August 2008

Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model

scientific article published on 28 April 2005

Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study ⬇️

scientific article

Efficacy evaluation of iclaprim in a neutropenic rat lung infection model with methicillin-resistant Staphylococcus aureus entrapped in alginate microspheres ⬇️

scientific article published on 8 December 2017

Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains

scientific article published on 15 June 2007

Efficacy of linezolid versus comparator therapies in Gram-positive infections ⬇️

scientific article published on May 1, 2003

Efficacy of vancomycin extended-dosing regimens for treatment of simulated Clostridium difficile infection within an in vitro human gut model ⬇️

scientific article published on 10 January 2016

Emergence of reduced susceptibility to metronidazole in Clostridium difficile

scientific article

Emerging drugs for treating methicillin-resistant Staphylococcus aureus

scientific article published on 01 September 2019

Enhanced surveillance of Clostridium difficile infection occurring outside hospital, England, 2011 to 2013. ⬇️

scientific article published on July 2016

Enterococcal intravascular catheter-related bloodstream infection: management and outcome of 61 consecutive cases

scientific article published in October 2002

Epidemiology of Clostridium difficile in infants in Oxfordshire, UK: Risk factors for colonization and carriage, and genetic overlap with regional C. difficile infection strains ⬇️

scientific article published on 16 August 2017

European Practice for CDI Treatment ⬇️

scientific article published in January 2018

Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection

scientific article

Evaluation of antimicrobial activity of ceftaroline against Clostridium difficile and propensity to induce C. difficile infection in an in vitro human gut model

scientific article published on 3 April 2013

Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model

scientific article published on 18 April 2011

Evolutionary history of the Clostridium difficile pathogenicity locus ⬇️

scientific article

Factors affecting removal of bacterial pathogens from healthcare surfaces during dynamic wiping ⬇️

article

Fidaxomicin: a new option for the treatment of Clostridium difficile infection ⬇️

scientific article published on 03 August 2012

Fluoroquinolones in the treatment of severe community-acquired

scientific article published on December 1, 2011

Future gazing in the management of multiply drug-resistant Gram-positive infection

scientific article published on September 2009

Gastrointestinal disorders and the critically ill. Clostridium difficile infection and pseudomembranous colitis

scientific article

Guidance document for prevention of Clostridium difficile infection in acute healthcare settings

scientific article published on 2 March 2018

Hash-Based Core Genome Multilocus Sequence Typing for Clostridium difficile

scientific article published on 23 December 2019

Health-care-associated infection: morbidity, mortality and costs.

scientific article published on February 2004

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection ⬇️

scientific article

Impact of recurrent Clostridium difficile infection: hospitalization and patient quality of life ⬇️

scientific article published on 13 June 2017

Impact of toxin gene PCR result on decisions to de-isolate patients: Do the ends justify the means?

article

In Vitro Activities of MCB3681 and Eight Comparators against Clostridium difficile Isolates with Known Ribotypes and Diverse Geographical Spread ⬇️

scientific article published on 19 December 2016

In situ diagnosis of intravascular catheter-related bloodstream infection: a comparison of quantitative culture, differential time to positivity, and endoluminal brushing

scientific article published in April 2005

In vitro susceptibility of genotypically distinct and clonal Clostridium difficile strains to oritavancin

scientific article published on 7 July 2008

International Clostridium difficile animal strain collection and large diversity of animal associated strains ⬇️

scientific article

Irritable bowel syndrome following Clostridium difficile infection ⬇️

Lack of evidence for an unmet need to treat Clostridium difficile infection in infants aged <2 years: expert recommendations on how to address this issue

scientific article published on 24 November 2014

Long-term surveillance of cefotaxime and piperacillin-tazobactam prescribing and incidence of Clostridium difficile diarrhoea

scientific article published on 26 May 2004

Measurement of ampicillin, vancomycin, linezolid and gentamicin activity against enterococcal biofilms

scientific article published on 7 February 2006

Mecillinam: a low-risk antimicrobial agent for induction of Clostridium difficile infection in an in vitro human gut model

scientific article published on 11 February 2009

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome

scientific article published on 27 May 2020

Microbiological Characterization and Clinical Outcomes After Extended-Pulsed Fidaxomicin Treatment for Clostridioides difficile Infection in the EXTEND Study

scientific article published on 06 November 2019

Microevolutionary analysis of Clostridium difficile genomes to investigate transmission

scientific article

Models for the study of Clostridium difficile infection

scientific article

Molecular epidemiology of endemic Clostridium difficile infection and the significance of subtypes of the United Kingdom epidemic strain (PCR ribotype 1)

scientific article

Molecular versus culture-based testing for gastrointestinal infection ⬇️

scientific article published on 25 October 2017

Multilocus sequence typing of Clostridium difficile

scientific article

Mycobacterial DNA extraction for whole-genome sequencing from early positive liquid (MGIT) cultures

scientific article published on 28 January 2015

Oritavancin does not induce Clostridium difficile germination and toxin production in hamsters or a human gut model

scientific article published on 16 August 2012

Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes

scientific article published on 21 September 2015

Parameters for the mathematical modelling of Clostridium difficile acquisition and transmission: a systematic review ⬇️

scientific article

Patient and strain characteristics associated with Clostridium difficile transmission and adverse outcomes ⬇️

scientific article published on 12 April 2018

Point-Counterpoint: What Is the Optimal Approach for Detection of Clostridium difficile Infection? ⬇️

scientific article published on 11 January 2017

Policy development for Clostridium difficile ⬇️

scientific article published on July 1, 2012

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

scientific article published on 26 September 2018

Predictors of first recurrence of Clostridium difficile infection: implications for initial management ⬇️

scientific article

Preface: Clostridium difficile Infection

scientific article published in March 2015

Prevalence of methicillin-resistant Staphylococcus aureus colonization among older residents of care homes in the United Kingdom

scientific article published on 24 May 2007

Probiotics and diarrhea: Data are not widely applicable

scientific article published on July 2007

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis ⬇️

scientific article

Progress with a difficult infection ⬇️

scientific article published on February 8, 2012

Pulsed-field gel electrophoresis can yield DNA fingerprints of degradation-susceptible Clostridium difficile strains

scientific article published on September 2002

Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study ⬇️

scientific article

Real-Life Evidence for Tedizolid Phosphate in the Treatment of Cellulitis and Wound Infections: A Case Series ⬇️

scholarly article by Sergey Shlyapnikov et al published 12 July 2018 in Infectious diseases and therapy

Recent initiatives to reduce the spread of meticillin-resistant Staphylococcus aureus

scientific article published on July 2009

Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing

scientific article published on 29 November 2012

Recurrence of dual-strain Clostridium difficile infection in an in vitro human gut model ⬇️

scientific article published on 29 April 2015

Regarding "Clostridium difficile ribotype does not predict severe infection".

scientific article published on 18 February 2013

Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection ⬇️

scientific article published on 5 March 2013

Renal failure and leukocytosis are predictors of a complicated course of Clostridium difficile infection if measured on day of diagnosis ⬇️

scientific article published on August 2012

Reply to 'Clostridium difficile period of increased incidence in hospitals'

scientific article published on 5 January 2015

Reply to Joseph et al.

scientific article published on 26 March 2018

Ridinilazole: a novel therapy for Clostridium difficile infection ⬇️

scientific article

Risk Factors for Clostridium difficile Acquisition in Infants: Importance of Study Design

scientific article published on 26 February 2013

Risk factors for Clostridium difficile infection in hospitalized patients with community-acquired pneumonia ⬇️

scientific article

Role of surface energy and nano-roughness in the removal efficiency of bacterial contamination by nonwoven wipes from frequently touched surfaces ⬇️

scientific article published on 14 March 2017

Screening for MRSA.

scientific article published on 16 April 2008

Short-term genome stability of serial Clostridium difficile ribotype 027 isolates in an experimental gut model and recurrent human disease ⬇️

scientific article (publication date: 2013)

Standardised surveillance of Clostridium difficile infection in European acute care hospitals: a pilot study, 2013. ⬇️

scientific article published on July 2016

Summary of Ceftaroline Fosamil Clinical Trial Studies and Clinical Safety ⬇️

scientific article published on September 1, 2012

Surveillance for resistance to metronidazole and vancomycin in genotypically distinct and UK epidemic Clostridium difficile isolates in a large teaching hospital

scientific article

Surveillance of iclaprim activity: In vitro susceptibility of gram-positive pathogens collected from 2012 to 2014 from the United States, Asia Pacific, Latin American and Europe ⬇️

scientific article published on 7 December 2017

Survey of Clostridium difficile infection surveillance systems in Europe, 2011. ⬇️

scientific article published on July 2016

Survey of diagnostic and typing capacity for Clostridium difficile infection in Europe, 2011 and 2014. ⬇️

scientific article published on July 2016

Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators ⬇️

scientific article

Susceptibility testing and reporting of new antibiotics with a focus on tedizolid: an international working group report ⬇️

scientific article published on 16 August 2017

The Control of Methicillin-Resistant Staphylococcus aureus Blood Stream Infections in England ⬇️

scientific article

The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens ⬇️

scientific article published on 20 September 2017

The potential for airborne dispersal of Clostridium difficile from symptomatic patients

scientific article published in June 2010

The predictive value of quantitative nucleic acid amplification detection of Clostridium difficile toxin gene for faecal sample toxin status and patient outcome ⬇️

scientific article published in PLoS ONE

The tide of antimicrobial resistance and selection

scientific article published on August 2009

The use of a rapid in situ test in the detection of central venous catheter-related bloodstream infection: a prospective study

scientific article published in March 2003

Tigecycline and the need for a new broad-spectrum antibiotic class

scientific article

Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model

scientific article published on 8 October 2006

Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection

scientific article published on 17 February 2009

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

scientific article published on February 2008

Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: a study of electronic health records

scientific article published on 17 August 2018

Two Distinct Patterns of Clostridium Difficile Diversity Across Europe Indicates Contrasting Routes of Spread ⬇️

scientific article published on 6 April 2018

Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID). ⬇️

scientific article published on 7 November 2014

Understanding Clostridium difficile Colonization ⬇️

scientific article published on 14 March 2018

Update on linezolid: the first oxazolidinone antibiotic

scientific article

What is the current role of algorithmic approaches for diagnosis of Clostridium difficile infection?

scientific article published on 27 October 2010

Whole genome sequencing and de novo assembly identifies Sydney-like variant noroviruses and recombinants during the winter 2012/2013 outbreak in England ⬇️

scientific article

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