List of works by Megan K. Levings

27 Effects of IL-17 On Effector and Regultory T Cell Subsets

scholarly article by Sarah Q. Crome et al published July 2007 in Cytokine

3rd Keystone Symposium on T regulatory cells

scientific article published on 01 July 2009

A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression

scientific article published on 01 May 2019

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

scientific article published on 19 January 2016

A composite immune signature parallels disease progression across T1D subjects

scientific article published on 05 December 2019

A method for expansion and retroviral transduction of mouse regulatory T cells

scientific article published on 19 November 2020

A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells

scientific article

A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies

scientific article published on 06 December 2018

ATG-induced expression of FOXP3 in human CD4(+) T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells.

scientific article

ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation

scientific article published on 26 October 2012

Acidity promotes the differentiation of immunosuppressive regulatory T cells

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

scientific article published on 27 February 2007

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses

scientific article

Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production.

scientific article published on 14 December 2010

Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk.

scientific article

Alleviating graft-versus-host disease by directing regulatory T cells to the gut … it is all about location, location, location

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

scientific article

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

An optimized method to measure human FOXP3+ regulatory T cells from multiple tissue types using mass cytometry.

scientific article published on 20 April 2018

Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease

scientific article published on 30 November 2019

Antigen-specific regulatory T cells: are police CARs the answer?

scientific article published on 19 June 2017

Biomarker-guided stratification of autoimmune patients for biologic therapy

scientific article published on 17 October 2017

Building a CAR-Treg: Going from the basic to the luxury model

scientific article published on 28 September 2020

CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance.

scientific article published in January 2015

CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC

scientific article published on 01 August 2010

CD4+ T-regulatory cells: toward therapy for human diseases.

scientific article published on June 2008

CD4+Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation

scientific article published on 10 November 2011

Can we throw the master-switch in autoimmune disease?

Cancer immunotherapies repurposed for use in autoimmunity

scientific article published on 01 April 2019

Cellular magnetic resonance imaging of monocyte-derived dendritic cell migration from healthy donors and cancer patients as assessed in a scid mouse model

scientific article

Characterization of regulatory T cells in obese omental adipose tissue in humans

scientific article published on 08 January 2019

Chemokine Induced Tolerance in Mouse Islet Allografts

scholarly article by Joel Montane et al published October 2012 in Canadian Journal of Diabetes

Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease.

scientific article published on 7 March 2017

Consequences of adjusting cell density and feed frequency on serum-free expansion of thymic regulatory T cells

Control of tissue-localized immune responses by human regulatory T cells

scientific article

Cross talk between human regulatory T cells and antigen presenting cells: Lessons for clinical applications

scientific article published on 10 December 2020

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

scientific article published on 03 December 2019

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells

scientific article published on 23 September 2010

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

scientific article published on 01 September 2010

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells

scientific journal article

Deconvolution and chromatic aberration corrections in quantifying colocalization of a transcription factor in three-dimensional cellular space

scientific article

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

scientific article

Development of GMP-Compatible Protocols for Thymus-Derived Regulatory T Cell Expansion

article

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells

scientific article

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

scientific article published on 28 September 2015

Discoveries in sphingolipid metabolism, spinocerebellar ataxia and autoimmune disease

article published in 2003

Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients

scientific article published on 19 January 2020

Ectopic germline recombination activity of the widely used Foxp3-YFP-Cre mouse: a case report

scientific article published on 03 December 2019

Effect of Ex Vivo-Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques.

scientific article published on 15 November 2016

Emerging strategies for treating autoimmune disorders with genetically modified Treg cells

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

scientific article published on 3 November 2017

Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs.

scientific article published on 30 March 2018

Environmental influences on T regulatory cells in inflammatory bowel disease

scientific article published on 03 February 2011

Erratum to “Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study” [Bi

article

Evaluating the Role of Tregs in the Progression of Multiple Myeloma

Evaluating the role of Tregs in the progression of multiple myeloma

scientific article published on 18 February 2019

Expression of RORC2 Controls the Development of Human Th17 Cells

article

F.75. Molecular and Functional Studies in T Cells from Healthy Carriers of FOXP3 Mutations

scholarly article by Rosa Bacchetta et al published January 2008 in Clinical Immunology

Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Enhances Adaptive Immunity to C difficile Toxin B

Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study.

scientific article published on 3 May 2016

Flagellin-specific human CAR Tregs for immune regulation in IBD

Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells.

scientific article

Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity.

scientific article published on January 2006

Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

scientific article published on 01 August 2020

Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.

scientific article published on 6 November 2007

Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells

scientific article published on September 2006

Graft-versus-host disease: suppression by statins.

scientific article published in November 2008

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

scientific article published in August 2002

Guidelines for standardizing T‐cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

scholarly article

Guiding regulatory T cells to the allograft

scientific article published on 14 November 2017

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation

scientific article

Helios is a marker, not a driver, of human Treg stability

Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans

scientific article published on 28 January 2013

Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells

scientific article published on 28 March 2016

How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity

scientific article published on 3 June 2016

Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.

scientific article

Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils

scientific article published on 11 January 2011

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

scientific article published on 01 December 2005

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

scientific article published in June 2001

IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.

scientific article published on May 2001

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance.

scientific article

Identifying the 'Achilles Heel' of type 1 diabetes

scientific article published on 24 December 2020

Impaired Th17 immunity in recurrent C. difficile infection is ameliorated by fecal microbial transplantation

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

In vitro generation of human T regulatory cells: generation, culture, and analysis of FOXP3-transduced T cells.

scientific article published on January 2013

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3

scientific article published on 01 December 2008

Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Monkeys

scholarly article by Paula Alonso Guallart et al published February 2015 in Biology of Blood and Marrow Transplantation

Induction of stable human FOXP3 + Tregs by a parasite‐derived TGF‐β mimic

Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo

scientific article

Inflammatory effects of ex vivo human Th17 cells are suppressed by regulatory T cells.

scientific article published on 18 August 2010

Innate Control of Tissue-Reparative Human Regulatory T Cells

scientific article published on 08 March 2019

Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity.

scientific article

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

scientific article published on January 1997

Integration of exogenous and endogenous co-stimulatory signals by CAR-Tregs

Interactions between islets and regulatory immune cells in health and type 1 diabetes

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

scientific article

Isolation, Expansion, and Characterization of Human Natural and Adaptive Regulatory T Cells

Isolation, expansion, and characterization of human natural and adaptive regulatory T cells

scientific article published on January 2007

Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections

scientific article published in 2021

Leishmania Exosomes Modulate Innate and Adaptive Immune Responses through Effects on Monocytes and Dendritic Cells

scientific article published on September 29, 2010

MASTering Treg function to promote tolerance

scientific article published on 01 October 2009

Manufacturing next-generation regulatory T-cell therapies

Megadose Bone Marrow and Regulatory T cells for the Induction of Immune Tolerance in Non-Human Primates Through Durable Mixed Hematopoietic Chimerism Across MHC-barriers

Methods to manufacture regulatory T cells for cell therapy

scientific article published on 15 April 2019

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

scientific article published on 25 March 2014

Migration Capacity of Thymic Regulatory T Cells can be Tuned by Expansion in Cytokine-Enriched Culture Conditions

article

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

scientific article published in January 2017

Molecular Regulation ofCellular Immunity by FOXP3

Molecular regulation of cellular immunity by FOXP3.

scientific article published on January 2009

Moving to tolerance: clinical application of T regulatory cells

scientific article published on 28 May 2011

Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation

Novel T regulatory cells come of age: The curious incident of a mouse in Tennessee, delayed thymectomy and chimeric receptors!

scientific article published on 03 December 2020

OR.7. Human CD4+CD25+ T Regulatory Cells Have Altered PKB Signalling Which Correlates with Suppressive Function

OR42 Expanded thymic regulatory T cells (Tregs) have low class I HLA expression levels and are HLA-DR negative – Potential for ‘Off-The-Shelf’ Cellular Therapy?

scholarly article by Esme Dijke et al published September 2017 in Human Immunology

Obesity-Associated Adipose Tissue Inflammation and Transplantation

scientific article

Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identity

Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity

PHLPP Regulates the Development, Function and Molecular Signaling Pathways of T Regulatory Cells

article

PHLPP Signaling in Immune Cells

PTEN is required for human Treg suppression of costimulation

PTEN is required for human Treg suppression of costimulation in vitro

Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function

scientific article published on 10 May 2020

Phenotype, Function and Expansion of Regulatory T Cells in the Cynomolgus Macaque (Macaca fascicularis)

scholarly article by Paula Alonso Guallart et al published February 2015 in Biology of Blood and Marrow Transplantation

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells

scientific article published on 30 October 2010

Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

scientific article

Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers

Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells

scientific article published in January 2008

Quantifying colocalization of a conditionally active transcription factor FOXP3 in three-dimensional cellular space

Recurrent Clostridioides difficile infection is associated with impaired Th17 immunity to TcdB

scientific article published on 27 November 2020

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis.

scientific article published on 10 February 2015

Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers

scientific article published on June 2012

Regulatory T-cells drive immune dysfunction in CLL

scientific article published on 02 June 2017

Repeated stimulation or tonic-signaling chimeric antigen receptors drive regulatory T cell exhaustion

Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells.

scientific article

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.

scientific article

SHIP regulates the reciprocal development of T regulatory and Th17 cells

scientific article

SHIP-deficient dendritic cells, unlike wild type dendritic cells, suppress T cell proliferation via a nitric oxide-independent mechanism

scientific article (publication date: 2011)

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

scientific article published on 12 February 2008

Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location

Su.98. Defining a Role for FOXP3 in Human Cd4+ T-Cells

Suppression assays with human T regulatory cells: a technical guide.

scientific article published on 12 December 2011

Suppression of Human Dendritic Cells by Regulatory T Cells

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells

scientific article published on 21 March 2019

T Regulatory Cells and Cancer Immunotherapy

T reg-specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome

scientific article published on 01 August 2020

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression

scientific article published on 8 February 2016

T regulatory cell therapy in transplantation: stability, localization and functional specialization

scientific article published on August 2012

T-Cell Specificity Matters in IBD: Impaired IL10 Production Revealed by OmpC-Tetramers

scientific article published on 06 July 2020

T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties.

scientific article published in July 2000

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

scientific article published on 04 June 2012

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis

scientific article published in March 2010

Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions

scientific article published on 13 June 2018

Taking regulatory T-cell therapy one step further

scientific article published on 01 October 2018

Targeting regulatory T cell metabolism in disease: Novel therapeutic opportunities

The Inflammatory Effects of ex vivo Human T Helper 17 Cells are Suppressed by T Regulatory Cells

scholarly article by Sarah Crome et al published January 2010 in Clinical Immunology

The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function

scientific article published on 13 August 2012

The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies

The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome

scientific article published in 2015

The outstanding questions in transplantation: It's about time….

scientific article published on 31 July 2017

The parasite cytokine mimic Hp ‐TGM potently replicates the regulatory effects of TGF‐β on murine CD4 + T cells

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

scientific article published on 6 October 2005

The role of FOXP3 in autoimmunity

scientific article

The role of FOXP3 in regulating immune responses

scientific article published on 15 August 2013

The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells

scientific article

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease

scientific article published on October 2008

The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells.

scientific article published in June 2009

The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells

scientific article published on 18 August 2010

Thymic progenitors of TCRαβ+ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development

scientific article published on 26 June 2017

Thymus-Derived Treg Infusion to Prevent Graft Rejection in Heart-Transplanted Children

Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice.

scientific article

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism

scientific article published on 8 June 2015

Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin

scientific article

Transduction of Human T Cell Subsets with Lentivirus

Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease.

scientific article

Treg gene signatures predict and measure type 1 diabetes trajectory

article

Type 1 T Regulatory Cells and Their Relationship with CD4+ CD25+ T Regulatory Cells

Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells

scientific article published on January 1, 2003

Type 1 T regulatory cells.

scientific article

What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies?

scientific article published on 01 September 2020

mRNA vaccines take on immune tolerance