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List of works by Jean-François Riou

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

scientific article published on 12 May 2009

5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES

scientific article

A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells

scientific article

A carbamate analogue of amsacrine with activity against non-cycling cells stimulates topoisomerase II cleavage at DNA sites distinct from those of amsacrine

scientific article published on 01 February 1997

A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells.

scientific article published on 22 June 2007

A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres

scientific article

Affinity and selectivity of G4 ligands measured by FRET.

scientific article

Altered topoisomerase I activity and recombination activating gene expression in a human leukemia cell line resistant to doxorubicin.

scientific article published on September 1993

Alternative splicing directs the expression of two D2 dopamine receptor isoforms.

scientific article

An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G-Quadruplex Topologies

scientific article published on 02 August 2011

Another link between phospholipid transmembrane migration and ABC transporter gene family, inferred from a rare inherited disorder of phosphatidylserine externalization

scientific article published on 01 December 1997

Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability

scientific journal article

Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

scientific article

Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines

scientific article

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

scientific article

Cellular effects of a new farnesyltransferase inhibitor, RPR-115135, in a human isogenic colon cancer cell line model system HCT-116.

scientific article published in January 1999

Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.

scientific article

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins

scientific article published on 29 June 2021

DNA and RNA quadruplex ligands.

scientific article

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

scientific article published on 8 February 2013

DNA topoisomerase I changes the mode of interaction between camptothecin drugs and DNA as probed by UV-resonance Raman spectroscopy

scientific article published on 4 November 1996

Detection of telomerase inhibitors based on g-quadruplex ligands by a modified telomeric repeat amplification protocol assay.

scientific article

Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene ⬇️

scientific article published on June 1, 1992

Effects of Taxotere on murine and human tumor cell lines

scientific article published on August 31, 1992

Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells

scientific article

Effects of two distamycin-ellipticine hybrid molecules on topoisomerase I and II mediated DNA cleavage: relation to cytotoxicity.

scientific article published in July 1995

From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): selectivity for topoisomerases I and II among acridine derivatives

scientific article published on 01 April 1996

Further SAR in the new antitumor 1-amino-substituted gamma-carbolines and 5H-benzo[e]pyrido[4,3-b]indoles series

scientific article published on 01 June 1992

G4 motifs affect origin positioning and efficiency in two vertebrate replicators

scientific article published on 12 February 2014

Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.

scientific article

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline

scientific article published on 5 August 2009

Identification of a new metabolite of CPT-11 (irinotecan): pharmacological properties and activation to SN-38 ⬇️

scientific article published on July 1, 1998

Inhibition of eukaryotic DNA topoisomerase I and II activities by indoloquinolinedione derivatives ⬇️

scientific article published on November 1, 1991

Interaction of an acridine dimer with DNA quadruplex structures.

scientific article

Interaction of telomestatin with the telomeric single-strand overhang.

scientific article

Interactions of cryptolepine and neocryptolepine with unusual DNA structures.

scientific article

Intracellular molecular interactions of antitumor drug amsacrine (m-AMSA) as revealed by surface-enhanced Raman spectroscopy

scientific article published on 01 November 1996

Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)

scientific article published on 06 February 2019

Kinetics of lactone hydrolysis in antitumor drugs of camptothecin series as studied by fluorescence spectroscopy.

scientific article published in March 1998

Metabolic and genomic adaptations to winter fattening in a primate species, the grey mouse lemur (Microcebus murinus).

scientific article

Modulation in Kinetics of Lactone Ring Hydrolysis of Camptothecins upon Interaction with Topoisomerase I Cleavage Sites on DNA ⬇️

scientific article published on May 19, 1998

Modulation of DNA Topoisomerase I Activity byp53

scientific article published in 1996

Molecular Interactions of DNA-Topoisomerase I and II Inhibitor with DNA and Topoisomerases and in Ternary Complexes: Binding Modes and Biological Effects for Intoplicine Derivatives

scientific article published in August 1994

Multiple hPOT1-TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3' toward 5', a feature due to a 3'-end binding preference and to structuring of telomeric DNA

scientific article published on 01 October 2021

Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

scientific article

Preclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors.

scientific article published on 15 April 2013

Presence of dopamine D-2 receptors in human tumoral cell lines

scientific article published in 1989

Purification and characterization of human DNA topoisomerase IIIalpha

scientific article

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

scientific article published on 13 July 2012

Repression of TERRA Expression by Subtelomeric DNA Methylation Is Dependent on NRF1 Binding

scientific article published on 07 June 2019

Resistance to anticancer drugs. Some strong tendencies in current research

scientific article published on January 1, 1992

Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase ⬇️

scientific article published on October 1, 2003

Salen-anthraquinone conjugates. Synthesis, DNA-binding and cleaving properties, effects on topoisomerases and cytotoxicity.

scientific article published on August 1996

Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis.

scientific article

Selective interactions of ethidiums with G-quadruplex DNA revealed by surface-enhanced Raman scattering.

scientific article published in August 2003

Senescence and cellular immortality

scientific article

Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad

scientific article

Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.

scientific article

Spectroscopic and Biochemical Characterisation of Self-Aggregates Formed by Antitumor Drugs of the Camptothecin Family

scientific article published in April 1998

Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase.

scientific article

Structure-activity relation in camptothecin antitumor drugs: why a detailed molecular characterisation of their lactone and carboxylate forms by Raman and SERS spectroscopies?

scientific article published on 01 March 1997

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

scientific article

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent

scientific article

Synthesis and biological properties of new benz[h]isoquinoline derivatives

scientific article published on 01 April 1994

Synthesis and evaluation of new 6-amino- substituted benzo[c]phenanthridine derivatives

scientific article published on 01 November 1993

Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel).

scientific article published on August 1994

Synthesis, DNA binding, topoisomerase II inhibition and cytotoxicity of two guanidine-containing anthracene-9,10-diones

scientific article published on 01 July 1998

Targeting human telomerase for cancer therapeutics.

scientific article

Targeting telomeres and telomerase

scientific article published on 24 July 2007

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.

scientific article published on 16 January 2004

Telomerase: a dimeric ménage à trois

scientific article published on 01 September 2007

Telomerase: a therapeutic target for the third millennium?

scientific article

Telomere regulation during ageing and tumorigenesis of the grey mouse lemur.

scientific article published on 14 April 2015

Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

scientific article

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.

scientific article published on 17 September 2010

The Bloom's syndrome gene product interacts with topoisomerase III

scientific article (publication date: 31 March 2000)

The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells

scientific article

The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells

scientific article

The benzophenanthridine alkaloid fagaronine induces erythroleukemic cell differentiation by gene activation.

scientific article

The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units

scientific article published on 27 November 2017

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.

scientific article published on 14 September 2017

[G-quadruplex DNA: myth or reality?]

scientific article published on 01 April 2003

[Telomeres and telomerase, new targets for anticancer chemotherapy]

scientific article published on 01 March 2006

in Vitro reconstitution of human telomerase activity

scientific article published on 01 February 1998

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