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List of works by Annette van der Helm-van Mil

2016 update of the EULAR recommendations for the management of early arthritis ⬇️

scientific article published on 15 December 2016

2017 EULAR recommendations for a core data set to support observational research and clinical care in rheumatoid arthritis

scientific article published on 4 January 2018

A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis

scientific article

A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis

scientific article published in March 2013

A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis

scientific article

A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis

scientific article published on 21 May 2013

A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

scientific article

A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.

scientific article

A new classification of HLA-DRB1 alleles based on acid-base properties of the amino acids located at positions 13, 70 and 71: impact on ACPA status or structural progression, and meta-analysis on 1235 patients with rheumatoid from two cohorts (ESPOI

scientific article

A search to the target tissue in which RA-specific inflammation starts: a detailed MRI study to improve identification of RA-specific features in the phase of clinically suspect arthralgia

scientific article published on 27 November 2019

A two-stage mixed-effects model approach for gene-set analyses in candidate gene studies

scientific article published on 14 October 2011

ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression

scientific article

Acute rheumatic fever and poststreptococcal reactive arthritis reconsidered

scientific article published on July 2010

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets

scientific article published on 31 March 2008

Aiming for a simpler early arthritis MRI protocol: can Gd contrast administration be eliminated?

scientific article

Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis

scientific article published in October 2013

An evaluation of molecular and clinical remission in rheumatoid arthritis by assessing radiographic progression

scientific article published on 3 January 2013

Anaemia to predict radiographic progression in rheumatoid arthritis

scientific article published on 26 April 2013

Arthritis of the large joints - in particular, the knee - at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis

scientific article

Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity

scientific article published on January 2006

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes

scientific article

Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis

scientific article published on October 2005

Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts

scientific article published in December 2013

Associations between APOE genotypes and disease susceptibility, joint damage and lipid levels in patients with rheumatoid arthritis

scientific article

Biomarkers for radiographic progression in rheumatoid arthritis

scientific article

Body mass index and extent of MRI-detected inflammation: opposite effects in rheumatoid arthritis versus other arthritides and asymptomatic persons

scientific article published on 22 October 2016

Brief Report: Clinical Trials Aiming to Prevent Rheumatoid Arthritis Cannot Detect Prevention Without Adequate Risk Stratification: A Trial of Methotrexate Versus Placebo in Undifferentiated Arthritis as an Example

scientific article published on 19 February 2017

Clinical factors, anticitrullinated peptide antibodies and MRI-detected subclinical inflammation in relation to progression from clinically suspect arthralgia to arthritis

scientific article published on 27 November 2015

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

scientific article published on 14 September 2008

Comparison of methodologies for analysing the progression of joint destruction in rheumatoid arthritis

scientific article published on 20 February 2013

Concordance between inflammation at physical examination and on MRI in patients with early arthritis

scientific article published on 12 December 2013

Correction: A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis

scientific article

Defining erosive disease typical of RA in the light of the ACR/EULAR 2010 criteria for rheumatoid arthritis; results of the data driven phase

scientific article

Development of clinically apparent synovitis: a longitudinal study at the joint level during progression to inflammatory arthritis

article

Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathways

scientific article published on 09 November 2020

Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis

scientific article published on 10 June 2011

Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia

Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example.

scientific article published on 3 May 2018

EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis

scientific article published on 6 October 2016

EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria

scientific article

EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis

scientific article published on 2 March 2012

Early intensive treatment normalises excess mortality in ACPA-negative RA but not in ACPA-positive RA

scientific article published on 22 June 2019

Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis

scientific article

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands

scientific article published on 22 September 2020

Evaluating joint destruction in rheumatoid arthritis: is it necessary to radiograph both hands and feet?

scientific article

Evaluating processes underlying the predictive value of baseline erosions for future radiological damage in early rheumatoid arthritis

scientific article

Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts

scientific article published on 5 January 2015

Evaluation of magnetic resonance imaging-detected tenosynovitis in the hand and wrist in early arthritis

scientific article published in April 2015

Evaluation of the diagnostic accuracy of hand and foot MRI for early Rheumatoid Arthritis

scientific article published on 27 April 2017

Factors that influence biological survival in rheumatoid arthritis: results of a real-world academic cohort from the Netherlands

scientific article published on 07 January 2021

Fatigue in rheumatoid arthritis; a persistent problem: a large longitudinal study

scientific article

Functional limitations in the phase of clinically suspect arthralgia are as serious as in early clinical arthritis; a longitudinal study

scientific article published on 29 June 2017

Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort

scientific article published on 09 November 2020

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

scientific article published on 5 October 2012

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

scientific article

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

scientific article

Genome-wide single-nucleotide polymorphism studies in rheumatology: hype or hope?

scientific article published on September 2008

How do general practitioners identify inflammatory arthritis? A cohort analysis of Dutch general practitioner electronic medical records

scientific article published on 7 January 2016

How to avoid phenotypic misclassification in using joint destruction as an outcome measure for rheumatoid arthritis?

scientific article published on 04 March 2010

IL2RA is associated with persistence of rheumatoid arthritis

scientific article

Imaging detected tenosynovitis of metacarpophalangeal and wrist joints: an increasingly recognised characteristic of rheumatoid arthritis

scholarly article published in Clinical and Experimental Rheumatology

Improved early identification of arthritis: evaluating the efficacy of Early Arthritis Recognition Clinics

scientific article published on 5 September 2012

Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis

scientific article published on 16 January 2020

Improving the feasibility of MRI in clinically suspect arthralgia for prediction of rheumatoid arthritis by omitting scanning of the feet

scientific article published on 30 September 2019

Increased frequency of intermetatarsal and submetatarsal bursitis in early rheumatoid arthritis: a large case-controlled MRI study

scientific article published on 23 November 2020

Is Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Still a More Severe Disease Than Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis? A Longitudinal Cohort Study in Rheumatoid Arthritis Patients Diagnosed From 2000

scientific article published on 20 December 2017

Is joint pain in patients with arthralgia suspicious for progression to rheumatoid arthritis explained by subclinical inflammation? A cross-sectional MRI study

scholarly article by Leonie E Burgers et al published 1 January 2019 in Rheumatology

Is shoulder involvement in clinically suspect arthralgia an early feature of rheumatoid arthritis? A longitudinal ultrasound study

scientific article published on 02 March 2020

Long-term outcome of rheumatoid arthritis defined according to the 2010-classification criteria

scientific article

Loss of metacarpal bone density predicts RA development in recent-onset arthritis

scientific article published on 18 January 2012

Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis.

scientific article published on 5 March 2013

MR signal intensity: staying on the bright side in MR image interpretation.

scientific article

MRI of hand and foot joints of patients with anticitrullinated peptide antibody positive arthralgia without clinical arthritis

scientific article published on 19 January 2013

MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF.

scientific article published on 02 August 2016

Macrophage migration inhibitory factor (MIF) -173 polymorphism is associated with clinical erythema nodosum in Löfgren's syndrome

scientific article published on 17 June 2014

Magnetic resonance imaging-detected inflammation is associated with functional disability in early arthritis-results of a cross-sectional study

scientific article

Mucocutaneous abnormalities in Chlamydia trachomatis-induced reactive arthritis

scientific article published on January 2010

No increased risk of valvular heart disease in adult poststreptococcal reactive arthritis

scientific article

No influence of melatonin on cerebral blood flow in humans

scientific article published in December 2003

Older age is associated with more MRI-detected inflammation in hand and foot joints

scientific article published on 29 September 2016

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

scientific article published on 01 November 2020

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development

scholarly article

Reappraisal of the diagnostic and prognostic value of morning stiffness in arthralgia and early arthritis: results from the Groningen EARC, Leiden EARC, ESPOIR, Leiden EAC and REACH.

scientific article published on 23 April 2015

Reasons for medical help-seeking behaviour of patients with recent-onset arthralgia

scientific article published on 6 September 2012

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins

scientific article

Relationship of multi-biomarker disease activity score and other risk factors with radiographic progression in an observational study of patients with rheumatoid arthritis

scientific article

Response to: "Does ACPA-negative RA consist of subgroups related to sustained DMARD-free remission and serological markers at disease presentation" by Masi and Fleischmann

scientific article published on 20 March 2020

Rheumatoid Arthritis and Tenosynovitis at the Metatarsophalangeal Joints: An Anatomic and MRI Study of the Forefoot Tendon Sheaths

scientific article published on 11 February 2020

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy

scientific article published on July 2010

Risk estimation in rheumatoid arthritis: from bench to bedside

scientific article published on 28 January 2014

Risk of rheumatoid arthritis development in patients with unclassified arthritis according to the 2010 ACR/EULAR criteria for rheumatoid arthritis

scientific article published on 7 March 2013

Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis

scientific article published on 25 January 2013

SPP1 rs9138 variant contributes to the severity of radiological damage in anti-citrullinated protein autoantibody-negative rheumatoid arthritis

scientific article

Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles

scientific article published on 13 July 2005

Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis

scientific article

Subclinical inflammation on MRI of hand and foot of anticitrullinated peptide antibody-negative arthralgia patients at risk for rheumatoid arthritis

scientific article

Subclinical synovitis in arthralgia: how often does it result in clinical arthritis? Reflecting on starting points for disease-modifying anti-rheumatic drug treatment

scientific article published on 17 December 2020

Substitution of the quantitative serological component in the 2010 criteria for RA with qualitative presence of three autoantibodies yields similar performance: response to the article by Regueiro et al

scientific article published on 15 April 2020

TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies

scientific article

TREAT Early Arthralgia to Reverse or Limit Impending Exacerbation to Rheumatoid arthritis (TREAT EARLIER): a randomized, double-blind, placebo-controlled clinical trial protocol

scientific article published on 16 October 2020

The 2010 ACR/EULAR criteria are not sufficiently accurate in the early identification of autoantibody-negative rheumatoid arthritis: Results from the Leiden-EAC and ESPOIR cohorts

scientific article

The 2010 ACR/EULAR criteria for rheumatoid arthritis: do they affect the classification or diagnosis of rheumatoid arthritis?

scientific article

The ACPA isotype profile reflects long-term radiographic progression in rheumatoid arthritis

scientific article

The ACPA recognition profile and subgrouping of ACPA-positive RA patients

scientific article published on 13 October 2011

The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level

scientific article published on 17 December 2015

The PTPN22 susceptibility risk variant is not associated with the rate of joint destruction in anti-citrullinated protein antibody-positive rheumatoid arthritis

scientific article

The preclinical phase of rheumatoid arthritis: what is acknowledged and what needs to be assessed?

scientific article

The prognostic value of baseline erosions in undifferentiated arthritis

scientific article published on 15 October 2009

The relation between physical joint examination and MRI-depicted inflammation of metatarsophalangeal joints in early arthritis

scientific article published on 03 April 2020

The value of the squeeze test for detection of subclinical synovitis in patients with arthralgia suspicious for progression to RA

scientific article published on 16 March 2020

To what extent do autoantibodies help to identify high-risk patients in systemic sclerosis?

scientific article published on 18 July 2018

Treat-to-Target Strategies in Rheumatoid Arthritis

scientific article published on 01 July 2019

Understanding the genetic contribution to rheumatoid arthritis

scientific article

Using a reference when defining an abnormal MRI reduces false-positive MRI results-a longitudinal study in two cohorts at risk for rheumatoid arthritis

scientific article published in October 2017

Validation of the EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis

scientific article published on 31 August 2017

Views on clinically suspect arthralgia: a focus group study

scientific article published on 15 August 2015

Walking disabilities are associated with tenosynovitis at the metatarsophalangeal joints: A longitudinal MRI-study in early arthritis

scientific article published on 22 September 2020

What is rheumatoid arthritis? Considering consequences of changed classification criteria

scientific article published on 22 September 2016

What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review

scientific article published on 09 April 2013

[Early recognition of rheumatoid arthritis]

scientific article published on 01 January 2011

[Progress due to genetic research on rheumatoid arthritis: hype or hope?]

scientific article published on 01 January 2009

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