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List of works by Hermann-Georg Holzhütter

2,3-Biphosphoglycerate, inorganic phosphate, pH and hemoglobin concentration in chronic renal failure of man

scientific article published on 01 January 1981

A Study on UV Filter Chemicals from Annex VII of European Union Directive 76/768/EEC, in the In Vitro 3T3 NRU Phototoxicity Test.

scientific article published on September 1998

A compartment model to calculate time-dependent concentration profiles of topically applied chemical compounds in the anterior compartments of the rabbit eye.

scientific article

A computational analysis of protein interactions in metabolic networks reveals novel enzyme pairs potentially involved in metabolic channeling

scientific article published on 5 October 2007

A computer assisted method to control the steady state of an ATP-regenerating assay.

scientific article published in January 1989

A conceptual mathematical model of the dynamic self-organisation of distinct cellular organelles

scientific article

A hypothetical model of cargo-selective rab recruitment during organelle maturation

scientific article published in May 2012

A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes

scientific article

A kinetic model for the interaction of nitric oxide with a mammalian lipoxygenase

scientific article published in May 1997

A kinetic model of phosphofructokinase from Plasmodium berghei. Influence of ATP and fructose-6-phosphate

scientific article published in January 1988

A kinetic model of vertebrate 20S proteasome accounting for the generation of major proteolytic fragments from oligomeric peptide substrates

scientific article published on September 2000

A mathematical model for the cell age-dependent decline of creatine in human cell cells

scientific article published on January 1984

A mathematical model to study short-term regulation of mitochondrial energy transduction

scientific article published in November 1985

A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism

scientific article published on 15 February 2018

A new method of parameter estimation from progress curves.

scientific article published in January 1984

A study of anoxia in rat hepatocytes

scientific article published on 01 January 1994

A theoretical approach to the evolution and structural design of enzymatic networks: linear enzymatic chains, branched pathways and glycolysis of erythrocytes

scientific article published in January 1987

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20 S proteasome

scientific article published in March 1999

A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis

scientific article

ATP-dependence of proteolysis in the pulp of rabbit molar teeth

scientific article published on January 1, 1991

An estimate on the effect of point mutation and natural selection on the rate of amino acid replacement in proteins

scientific article published in January 1984

Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

scientific article

Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test

scientific article (publication date: 2013)

Assessment of proteasomal cleavage probabilities from kinetic analysis of time-dependent product formation

scientific article

Balance of glucose utilization in rabbit reticulocytes.

scientific article published in January 1981

Both lysine-clusters of the NH2-terminal prion-protein fragment PrP23-110 are essential for t-PA mediated plasminogen activation

scientific article published in March 2004

CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases

scientific article published on 11 November 2021

Calculation of kinetic parameters of a reversible enzymatic reaction in states of maximal activity

scientific article published in January 1990

CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism

scientific article

Characterization of Lipid and Lipid Droplet Metabolism in Human HCC.

scientific article published on 27 May 2019

Characterizing the N-terminal processing motif of MHC class I ligands

scientific article

Combining bioinformatics resources for the structural modelling of eukaryotic metabolic networks

scientific article published in January 2005

Compartmental analysis: theoretical aspects and application

scientific article published in January 1985

Composition of metabolic flux distributions by functionally interpretable minimal flux modes (MinModes).

scientific article published in January 2006

Computational analysis of protein-protein interactions in metabolic networks of Escherichia coli and yeast.

scientific article

Computational design of reduced metabolic networks

scientific article published in October 2004

Computational lipidology: predicting lipoprotein density profiles in human blood plasma

scientific article

Computer aided optimization of carbon atom labeling for tracer experiments.

scientific article published in January 2008

Computer simulations suggest a key role of membranous nanodomains in biliary lipid secretion

scientific article

Correction: The importance of membrane microdomains for bile salt-dependent biliary lipid secretion (doi:10.1242/jcs.211524)

scientific article published on 19 March 2018

Corrigendum to "Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species"

scholarly article published in International Journal of Cell Biology

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

scholarly article by Astrid Borchert published in September 2018

CySBML: a Cytoscape plugin for SBML ⬇️

scientific article published on 05 July 2012

Dermal and inhalation acute toxic class methods: test procedures and biometric evaluations for the Globally Harmonized Classification System

scientific article published on 12 March 2003

Dual role of oxygen during lipoxygenase reactions

scientific article published in May 2005

Dynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones

EEC/COLIPA project on in vitro phototoxicity testing: First results obtained with a Balb/c 3T3 cell phototoxicity assay ⬇️

scientific article published on August 1, 1994

Effects of reactive oxygen species on eicosanoid metabolism in human endothelial cells ⬇️

scientific article published on March 1, 1992

Efficiency and design of simple metabolic systems

scientific article published on January 1985

Enzymatic features of the glucose metabolism in tumor cells

scientific article published on 10 June 2011

Enzyme maintenance effort as criterion for the characterization of alternative pathways and length distribution of isofunctional enzymes

scientific article published on 2 June 2011

Estimation of metabolic flux rates in liver purine catabolism of tumour-bearing mice by computer simulation of radioactive tracer experiments

scientific article published in January 1994

Estimation of steady-state flux rates in metabolic systems by computer simulations of radioactive tracer experiments.

scientific article published in October 1993

Evaluation of 41 candidate gene variants for obesity in the EPIC-Potsdam cohort by multi-locus stepwise regression

scientific article

Evidence for the existence of a non-catalytic modifier site of peptide hydrolysis by the 20 S proteasome

scientific article published on 01 July 2000

Experience with the particulate prostaglandin endoperoxide synthase assay for testing non-steroidal antiinflammatory drugs

scientific article published in November 1991

FASIMU: flexible software for flux-balance computation series in large metabolic networks

scientific article

Finding one's way in proteomics: a protein species nomenclature

scientific article published on 9 September 2009

Fluxviz - Cytoscape plug-in for visualization of flux distributions in networks

scientific article

HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology.

scientific article published on 19 June 2018

Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.

scientific article published in January 2003

How an inhibitor of the HIV-I protease modulates proteasome activity

scientific article

Human T cell responses to endogenously presented HLA-A*0201 restricted peptides of Simian virus 40 large T antigen

scientific article

IRAG working group 2. CAM-based assays. Interagency Regulatory Alternatives Group

scientific article published on 01 January 1997

Identification and characteristics of a novel mitochondrial 5'-nucleotidase in rat liver.

scientific article published in April 1989

Identification and characteristics of a novel mitochondrial ATPase in rat liver

scientific article published on 01 July 1987

Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases

scientific article published on October 2001

Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.

scientific article

In vitro phototoxicity testing: development and validation of a new concentration response analysis software and biostatistical analyses related to the use of various prediction models.

scientific article

Inactivation of 15-lipoxygenases by acetylenic fatty acids

scientific article published on January 1, 1991

Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks

scientific article

Influence of erythropoietin treatment on 2,3-bisphosphoglycerate and O2-affinity of red blood cells in children with renal anemia

scientific article published on 01 January 1990

Infrared spectroscopic ellipsometry (IRSE) and X-ray photoelectron spectroscopy (XPS) monitoring the preparation of maleimide-functionalized surfaces: from Au towards Si (111)

Interpretation of non-invasive breath tests using (13)C-labeled substrates--a preliminary report with (13)C-methacetin

scientific article published on January 2009

Interpretation of the inotropic effect of 2,3-butanedione monoxime on the isometric twitch of guinea-pig papillary muscle

scientific article published in October 1994

Interrelations between glycolysis and the hexose monophosphate shunt in erythrocytes as studied on the basis of a mathematical model

scientific article published in January 1988

Joint effect of unlinked genotypes: application to type 2 diabetes in the EPIC-Potsdam case-cohort study

scientific article published on 23 April 2015

Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

scientific article published on 10 June 2012

Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28.

scientific article

Kinetic hybrid models composed of mechanistic and simplified enzymatic rate laws--a promising method for speeding up the kinetic modelling of complex metabolic networks

scientific article published in January 2009

Kinetic model of glucose-6-phosphate dehydrogenase from red blood cells. Parameter estimation from progress curves and simulation of regulatory properties

scientific article

Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy

scientific article published on 12 September 2012

MAPPP: MHC class I antigenic peptide processing prediction.

scientific article

METANNOGEN: compiling features of biochemical reactions needed for the reconstruction of metabolic networks

scientific article

Macrophage cholesteryl ester hydrolases and hormone-sensitive lipase prefer specifically oxidized cholesteryl esters as substrates over their non-oxidized counterparts

scientific article

Mathematical Modeling of Cellular Metabolism

scientific article

Mathematical analysis of enzymic reaction systems using optimization principles

scientific article published on October 1991

Mathematical model of pyruvate kinase of chicken erythrocytes.

scientific article published in January 1983

Mathematical modelling of energy and redox metabolism of G6PD-deficient erythrocytes

scientific article published in January 1990

Mathematical modelling of metabolic pathways affected by an enzyme deficiency.

scientific article published in January 1990

Mathematical modelling of metabolic pathways affected by an enzyme deficiency. A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells

scientific article published in May 1985

Mathematical modelling of metabolic pathways affected by an enzyme deficiency. Energy and redox metabolism of glucose-6-phosphate-dehydrogenase-deficient erythrocytes

scientific article published in July 1989

Mathematical modelling of the purine metabolism of the rat liver

scientific article published in September 1990

Metabolic Consequences of TGFb Stimulation in CulturedPrimary Mouse Hepatocytes Screened from Transcript Data with ModeScore

scientific article

Metabolic gradients as key regulators in zonation of tumor energy metabolism: a tissue-scale model-based study

scientific article

Metannogen: annotation of biological reaction networks

scientific article published on 08 August 2011

Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach

scientific article published on 19 September 2014

Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics

scientific article published on 8 February 2008

Modelling the reaction mechanism of the reticulocyte lipoxygenase

scientific article published on 01 January 1987

Models for the regulation of purine metabolism in rat hepatocytes: evaluation of tracer kinetic experiments

scientific article published in July 1997

Modern biostatistical methods for assessing in vitro/in vivo correlation of severely eye irritating chemicals in a validation study of in vitro alternatives to the Draize eye test

scientific article published on August 1995

Molecular and cellular regulation of pyruvate kinase in red blood cells.

scientific article published in January 1984

Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels

scholarly article

Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis

scientific article

Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism

scientific article published on 31 August 2012

Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species

scientific article

Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site

scientific article published on December 1998

Oxidation of a methionine residue in subtilisin-type proteinases by the hydrogen peroxide/borate system--an active site-directed reaction

scientific article published in January 1988

Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network

scientific article published on 21 November 2012

Phosphorus-31 magnetic resonance spectroscopy of the heart. New perspectives and development trends

scientific article published in September 1991

Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients

scientific article

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome

scientific article published on 25 January 2009

Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices

scholarly article by Nikolaus Berndt et al published October 2018 in Archives of Toxicology

Prediction of temporal gene expression. Metabolic opimization by re-distribution of enzyme activities

scientific article published in November 2002

Pruning genome-scale metabolic models to consistent ad functionem networks

scientific article published in January 2007

Pyruvate utilization of rabbit reticulocytes--a compartmental study

scientific article published in January 1990

Quantification of pathways of glucose utilization and balance of energy metabolism of rabbit reticulocytes.

scientific article published in June 1982

Quantifying the contribution of defective ribosomal products to antigen production: a model-based computational analysis

scientific article

Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism

scientific article

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

scientific article

Rapid degradation of solid-phase bound peptides by the 20S proteasome

scientific article published on 28 July 2013

Rapid flip-flop of phospholipids in endoplasmic reticulum membranes studied by a stopped-flow approach

scientific article

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Red cell creatine in steady state and stimulated erythropoiesis.

scientific article published on January 1983

Red cell creatine in term and preterm, adequate and small for gestational age newborns after normal pregnancy or risk conditions. I. Statistical analysis of creatine in various groups of newborns

scientific article published on January 1983

Regulation of liver metabolism by the endosomal GTPase Rab5.

scientific article published on 30 April 2015

Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione

scientific article published on 11 November 2017

SEE: structured representation of scientific evidence in the biomedical domain using Semantic Web techniques

scientific article

SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry.

scientific article published in January 1990

Sequential metabolic phases as a means to optimize cellular output in a constant environment

scientific article

Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing

scientific article published on January 1997

Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110.

scientific article published in May 2003

Stochastic simulation of hemagglutinin-mediated fusion pore formation

scientific article published on September 2001

Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure.

scientific article

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team

scientific article

The ECVAM Prevalidation Study on the Use of EpiDerm for Skin Corrosivity Testing.

scientific article published in May 2000

The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy ⬇️

scientific article published on November 1, 2013

The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test.

scientific article

The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity

scientific article published on 13 January 2017

The energy metabolism of pyruvate kinase deficient red blood cells.

scientific article published in January 1983

The generalized flux-minimization method and its application to metabolic networks affected by enzyme deficiencies

scientific article published on 17 October 2005

The importance of membrane microdomains for bile salt-dependent biliary lipid secretion

scientific article published on 2 February 2018

The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model

scientific article published on 2 February 2011

The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere

scientific article published in July 1999

The mechanism of inactivation of lipoxygenases by acetylenic fatty acids

scientific article published on March 1984

The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks

scientific article published in July 2004

The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes.

scientific article published on September 1999

The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling

scientific article

The speciation of the proteome

scientific article published on 18 July 2008

The stability and robustness of metabolic states: identifying stabilizing sites in metabolic networks

scientific article published on 13 November 2007

The structure of metabolic systems: a theoretical approach

scientific article published on January 1990

The use of progress curves for the estimation of inactivation rate constants of enzymes

scientific article published on 01 January 1985

The virtual liver: a multidisciplinary, multilevel challenge for systems biology

scientific article published on 13 January 2012

The virtual liver: state of the art and future perspectives

scientific article

Transitions of hepatic purine metabolism of Ehrlich ascites tumor bearing mice in different phases of tumor growth.

scientific article published in October 1994

Uncovering metabolic objectives pursued by changes of enzyme levels

scientific article published in March 2009

Use of mathematical models for predicting the metabolic effect of large-scale enzyme activity alterations. Application to enzyme deficiencies of red blood cells

scientific article published on 01 April 1995

[Immunologic determination of glucose-6-phosphate dehydrogenase concentration of red blood cells of G6PD defect carriers]

scientific article published on 01 January 1985

[Results of the first phase of the ECVAM project "prevalidation and validation of three in vitro embryotoxicity tests"]

scientific article published on 01 January 1998

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