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List of works by Peter-Michael Kloetzel

20 S proteasomes are imported as precursor complexes into the nucleus of yeast

scientific article

20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2L(d) epitope from a recombinant protein

scientific article published on 8 February 2007

A large fraction of HLA class I ligands are proteasome-generated spliced peptides.

scientific article published on 20 October 2016

Adult human liver contains intermediate-type proteasomes with different enzymatic properties

scientific article

Analysis of proteasome generated antigenic peptides by mass spectrometry

scientific article published in January 2013

Antitopes define preferential proteasomal cleavage site usage.

scientific article published on 18 April 2008

BSc2118 is a novel proteasome inhibitor with activity against multiple myeloma

scientific article published on 31 March 2010

Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features

scientific article published on 21 March 2017

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

scientific article

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma

scientific article

Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases

scientific article (publication date: October 2002)

Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells

scientific article published on August 2006

Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope

scientific article published on 17 January 2017

De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder

scientific article

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

scientific article published on January 10, 2011

Emerging roles of immunoproteasomes beyond MHC class I antigen processing ⬇️

scientific article published on 02 March 2012

Exposure to Melan-A/MART-126-35 tumor epitope specific CD8(+)T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)

scientific article published on 4 May 2016

Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis

scientific article

HLA-B27-restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis

scientific article

Herp Regulates Hrd1-mediated Ubiquitylation in a Ubiquitin-like Domain-dependent Manner ⬇️

scientific article published on December 13, 2010

Human immunodeficiency virus‐1 Tat protein interacts with distinct proteasomal α and β subunits ⬇️

scientific article published on October 9, 2003

Humoral anti-proteasomal autoimmunity in dilated cardiomyopathy

scientific article published in January 2010

IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response

scientific article

Immunoproteasomes are important for proteostasis in immune responses

scientific article published in February 2013

Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme ⬇️

scientific article published on January 31, 2012

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress

scientific article

Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes

scientific article published on 3 April 2003

Inhibition of the ubiquitin-proteasome pathway induces differential heat-shock protein response in cardiomyocytes and renders early cardiac protection

scientific article published in March 2002

Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing

scientific article

Lack of evidence for a pathogenic role of proteasome-directed autoimmunity in dilated cardiomyopathy

scientific article published on 25 March 2010

Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity

scientific article published on April 2002

Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination

scientific article

Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag ⬇️

scientific article published on May 3, 2012

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system

scientific article

Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities

scientific article published on 22 May 2013

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I‐binding peptides in vivo ⬇️

scientific article published on March 1, 2011

PI31 is a modulator of proteasome formation and antigen processing

scientific article

Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain

scientific article

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

scientific article published on 03 October 2016

Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver

scientific article

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia

scientific article

Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue

scientific article

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells

scientific article published on 17 May 2010

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma

scientific article published on 20 December 2007

T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomes

scientific article published on 31 October 2013

The FAT10- and ubiquitin-dependent degradation machineries exhibit common and distinct requirements for MHC class I antigen presentation ⬇️

scientific article published on February 19, 2012

The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing

scientific article

The effect of the interferon-gamma-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context

scientific article

The effects of the histone deacetylase inhibitor valproic acid on cell cycle, growth suppression and apoptosis in multiple myeloma.

scientific article published in February 2006

The proteasome and MHC class I antigen processing

scientific article

The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition

scientific article published on 24 September 2015

The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum

scientific article

The role of the proteasome activator PA28 in MHC class I antigen processing

scientific article (publication date: October 2002)

The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway

scientific article

Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines

scientific article published on 26 May 2005

Trypanosoma cruzi infection down-modulates the immunoproteasome biosynthesis and the MHC class I cell surface expression in HeLa cells

scientific article

Ubiquitin-proteasome pathway as a new target for the prevention of restenosis

scientific article published in January 2002

Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection

scientific article

α-Keto phenylamides as P1'-extended proteasome inhibitors

scientific article

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