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List of works by David Holmes

'Hot' and cold therapy reduces obesity

ASXL2—director of skeletal and metabolic homeostasis

Acinar-cell reprogramming generates functional β cells that persist for a long time

Acute kidney injury: renal hazards of anticoagulant therapy

scientific article

Adipocyte exosomes drive melanoma progression

Adipose tissue: Angiogenic factor regulates beiging

scientific article published on 26 August 2016

Adipose tissue: Key role for FGF21 in GLP1-mediated weight loss

scientific article published on 17 October 2016

Adipose tissue: Macrophage retention inhibits beige adipogenesis in obesity

Adipose tissue: New route to functional human beige adipocytes

scientific article published on 24 March 2017

Adrenal function: Paradigm shift for ACTH suppression

scientific article published on 2 September 2016

Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene

scientific article (publication date: 10 January 2002)

Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production

scientific article

Antidiabetic effects of a mAb targeting FABP4

Antiplatelet agent promotes bone formation

Attenuated incretin effect after glucose loading in monogenic HNF1A diabetes

BMI-increasing variant identified in Samoans

Benefits of brown adipose tissue transplantation

Biomarkers: Mannose levels predict insulin resistance

scientific article

Bone diseases: Dual sclerostin-DKK1 antibody outperforms monotherapy

scientific article published on 17 June 2016

Bone: Antifracture efficacy of growth hormone-confirmation at long last

scientific article published on 22 September 2015

Brain imaging: Cross-sex hormones alter grey matter structures

scientific article published on 21 October 2016

Breast cancer: Increased risk with concurrent dietary and EDC exposures

CSF-1 suppresses crystal formation

Calcium–T2DM link strengthens

Cancer target of mitotane identified

Cholesterol efflux capacity—inverse association with incident cardiovascular disease

Cholesterol metabolites regulate motor neuron function

Concerns about long-term use of GLP-1 analogues

Death-defying β cells

Diabetes. Genetically engineered Lactobacilli reprogram intestinal cells to secrete insulin and ameliorate hyperglycaemia

scientific article

Diabetes: Artificial pancreas--first head-to-head comparison of dual-hormone and single-hormone systems

scientific article

Diabetes: Natural autoantibodies protect against T1DM.

scientific article published on 5 August 2016

Diabetes: Plasma membrane key to diet-induced insulin resistance

scientific article

Diabetes: Protective role for fish-derived fatty acids

Direct beige-to-white conversion

Disease watch: Zika virus - concerns for male fertility

scientific article published on 18 November 2016

Don't stress dad — it's bad for your kids' health

article

Donor-derived bone marrow cells become adipocytes in recipients

Dual mode of action of SSRIs on bone remodelling

ERRγ–pre-eclampsia link strengthens

ERα signalling drives β-cell formation and replication

scientific article published on 16 June 2015

End-stage renal disease: Link between prehypertension and risk of ESRD grows stronger

scientific article published on 15 October 2013

Endocrine disruptors: Air pollution linked to insulin resistance

scientific article published on 17 October 2016

Endocrine disruptors: Childhood exposure predicts later adiposity

scientific article published on 19 August 2016

Endocrine disruptors: Reproductive consequences of analgesic use during pregnancy

scientific article published on 12 February 2016

Epigenetic reversal attenuates renal fibrosis

Exome sequencing aids targeted treatment of inborn errors of metabolism

article

FGF1 restores blood glucose levels and insulin sensitivity in diabetic mice

Fibroblasts reprogrammed to produce insulin

Fracture risk after bariatric surgery

Genetic insight into antithyroid drug-induced agranulocytosis in a European population

article published in 2016

Genetic variation underpins metformin response

Genetics: Founder mutations identified in an inherited form of the metabolic syndrome

scientific article

Genetics: Unlocking the secrets of adult human height

scientific article published on 17 February 2017

Glomerular disease: MN linked to improved prognosis in anti-GBM disease

scientific article published on 8 October 2013

Glucose levels on hospital admission predict risk of diabetes mellitus

Gut microbiota: Antidiabetic drug treatment confounds gut dysbiosis associated with type 2 diabetes mellitus

scientific article published on 15 December 2015

Hepatic insulin resistance—missing link identified

scholarly article by David Holmes published 24 February 2015 in Nature Reviews Endocrinology

High-intensity interval training benefits patients with T2DM

Hydration status linked to risk of contrast-induced AKI

Hypoglycaemia risk with dual use of DPP-4 inhibitors and sulphonylureas

Identification of glucose-regulated genes in human mesangial cells by mRNA differential display

scientific article

Immunometabolism: ER stress drives obesity by reducing energy expenditure

Incidence trends in the USA

Increased complexity of the glomerular extracellular matrix

Inflammation: Immune recovery drives bone loss

scientific article published on 13 October 2015

Inflammation: Leptin deficiency protects against SLE.

scientific article published on 17 October 2016

Irisin boosts bone mass

Key role for S1P in bone remodelling

Link between T1DM and epilepsy strengthens

MSC transplant prevents β-cell dysfunction

Metabolism: Adipose and nonadipose effects of FGF21 delineated

Metabolism: Exercise resistance decoded

scientific article published on 17 March 2017

Metabolism: Fasting induces FGF21 in humans

scientific article published on 20 November 2015

Metabolism: kisspeptin signalling linked to obesity

scientific article

Metformin linked to vitamin B12 deficiency

article published in 2016

Mortality risk in the CRISTAL trial

Mortality unaffected by rise in use of imaging tests

article published in 2016

Neuroendocrinology: Leptin attenuates HPA-axis activation and stress responses

scientific article

Neuronal origin of osteogenic effects of magnesium

scholarly article by David Holmes published 16 September 2016 in Nature Reviews Endocrinology

New spine BMD loci associated with fractures

Novel protective role of H-Ferritin

Obesity: Medicinal mushroom reduces obesity by modulating microbiota

scientific article published on 14 July 2015

On-off switch for obesity

PTH regulates bone marrow progenitor fate

Pancreas: FGF21 gets the juices flowing

scientific article

Paradigm shift in genetic testing for neonatal diabetes mellitus—new framework for clinical care

Parathyroid function: Key role for dicer-dependent miRNAs

scientific article

Physiologic role of IL-1β in glucose homeostasis

Pituitary gland: Sex difference in comorbidity burden associated with nonfunctioning pituitary adenomas

scientific article published on 20 May 2016

Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors

scientific article

Predicting the benefits and risks of PCSK9 inhibition

Reproductive endocrinology: Acquisition of kisspeptin responsiveness is key to reversal of hypogonadotropic hypogonadism

scientific article published on 10 June 2016

Reproductive endocrinology: Puberty timing and cancer risk

scientific article

Reprogrammed pancreatic δ-cells restore insulin production

article

Reversal of age-related decline in fracture repair—the benefits of a youthful circulation

SDF-1 dysregulation mediates diabetic stem cell mobilopathy

SOCS-3 expression detrimental in AKI

Saturated fatty acids—not all bad news

Sclerostin levels linked to CKD outcomes

Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor

scientific article

Stem cells: Budding renal progenitors.

scientific article published on 3 December 2013

Stem cells: Decorin has role in differentiation

scientific article published on 17 December 2013

Stones: Higher risk of cardiovascular events

scientific article published on 24 December 2013

Sugar drug reverses atherosclerosis

article by David Holmes published 22 April 2016 in Nature Reviews Endocrinology

Sweat-sensing patch for glucose monitoring and drug delivery

article published in 2016

Systems genetics links Bicc1 to bone development

article

Targeting fat deposits—one step closer

article by David Holmes published 19 August 2014 in Nature Reviews Endocrinology

The renoprotective role of miR-126

The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease

scientific article

Time to rethink intensive treatment for all?

Transplantation comBATs obesity

Transplantation: Paradigm shift in graft evaluation

scientific article published on 19 November 2013

Unlocking the potential of thyroid autoantibodies

Unravelling the path to steatohepatitis

Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2.

scientific article published on 26 November 2007

Vascular endothelial growth factor synergistically enhances induction of E-selectin by tumor necrosis factor-alpha

scientific article

Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.

scientific article

Vitamin D-induced autophagy prevents steatosis

WAT browning—key feature of cancer-associated cachexia

miR-92a hits the mark

β-cell heterogeneity — key to unlocking islet regeneration

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