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List of works by Markus G Manz

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

A comprehensive surface proteome analysis of myeloid leukemia cell lines for therapeutic antibody development.

scientific article published on 30 January 2014

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

scientific article published in Nature Communications

A mouse model for the human pathogen Salmonella typhi

scientific article published on October 2010

A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies

scientific article

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

scientific article published on 11 January 2017

A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

scientific journal article

Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development

scientific article

Acute central nervous system complications and ammonium levels in adult patients with acute lymphoblastic leukemia receiving l-asparaginase

Allo-SCT for multiple myeloma in the era of novel agents: a retrospective study on behalf of Swiss Blood SCT.

scientific article published on 3 September 2012

Allogeneic hematopoietic cell transplantation in patients with GATA2 deficiency—a case report and comprehensive review of the literature

scientific article published on 13 June 2018

Amyloid Fibrils Enhance Transport of Metal Nanoparticles in Living Cells and Induced Cytotoxicity

scientific article

Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells

scientific article published on 01 May 2020

Author Correction: Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

scientific article published on 26 November 2019

BIOLOGY OF HEMATOPOIETIC STEM CELLS AND PROGENITORS: Implications for Clinical Application

scientific article (publication date: April 2003)

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

scientific article published on 17 March 2014

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

scientific article published on 2 February 2015

Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes

scientific article published on 09 September 2011

CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection

scientific article

CD34CD38 leukemic stem cell frequency to predict outcome in acute myeloid leukemia

scientific article published on 12 December 2018

CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions.

scientific article published on 6 April 2018

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

scientific article published on 25 April 2016

Cladribine, cytarabine and idarubicin (CLA-Ida) salvage chemotherapy in relapsed acute myeloid leukemia (AML).

scientific article published on 13 October 2016

Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments

scientific article

Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation

scientific article published on 16 March 2020

Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations

scientific article published on 22 November 2004

Comparative therapeutic value of post-remission approaches in patients with acute myeloid leukemia aged 40-60 years.

scientific article

Comparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratio

scientific article published on 15 July 2016

Continuously infused amphotericin B deoxycholate for primary treatment of invasive fungal disease in acute myeloid leukaemia

scientific article published on 12 February 2018

Correction: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS

scientific article published on 30 July 2020

Corrigendum: Development and function of human innate immune cells in a humanized mouse model

scientific article published in December 2017

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

scientific article published on 14 May 2012

DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis

scientific article

Daratumumab for relapsed or refractory AL amyloidosis with high plasma cell burden

scientific article published on 06 November 2019

Dendritic cell development from common myeloid progenitors.

scientific article published in June 2001

Dendritic cell homeostasis

scientific article published on 27 January 2009

Dendritic cell homeostasis is maintained by nonhematopoietic and T-cell-produced Flt3-ligand in steady state and during immune responses.

scientific article

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

scientific article published on 18 April 2004

Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals.

scientific article published on 15 August 2017

Development and function of human innate immune cells in a humanized mouse model

scientific article

Development of CD8 -Positive Dendritic Cells from a Common Myeloid Progenitor

scientific article published in Science

Development of a human adaptive immune system in cord blood cell-transplanted mice

scientific article published in April 2004

Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia

scientific article published on 27 June 2019

Development of monocytes, macrophages, and dendritic cells

scientific article (publication date: 5 February 2010)

Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors

scientific article published in February 2005

Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue.

scientific article published on 3 November 2006

Distinct factors determine the kinetics of disease relapse in adults transplanted for acute myeloid leukaemia.

scientific article published on 7 December 2017

Dynamic regulation of hematopoietic stem cell cycling

scientific article published on 15 July 2011

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

scientific article (publication date: 14 February 2011)

EBV renders B cells susceptible to HIV-1 in humanized mice

scientific article published on 23 June 2020

Early Defect Prethymic in Bone Marrow T Cell Progenitors in Athymic nu/nu Mice

scientific article published on 01 August 2003

Efficacy of Azacitidine in De Novo and Relapsed Acute Myeloid Leukemia: A Retrospective Comparative Study

scientific article published on 25 September 2015

Efficacy of anti-fungal but not anti-bacterial prophylaxis in intensive primary AML therapy: a real-world, retrospective comparative single-centre study

scientific article published on 23 July 2014

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

scientific article published on 25 July 2011

Emergency granulopoiesis

scientific article published on 22 April 2014

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

scientific article

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

scientific article

Engineered humanized bone organs maintain human hematopoiesis in vivo.

scientific article published on 2 February 2018

Engineering of a functional bone organ through endochondral ossification

scientific article published on 11 February 2013

Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo.

scientific article published on 4 May 2016

Ex vivo expansion of hematopoietic stem cells: mission accomplished?

scientific article published on 29 December 2011

Fas (CD95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance

scientific article published on January 2014

Fate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs

scientific article published on 07 August 2019

Finally: development of humanized lymph nodes

article

Flt3 in regulation of type I interferon-producing cell and dendritic cell development

scientific article published on 14 March 2007

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo

scientific article

Flt3L, DCs, and NTregs: team contra GVHD?

scientific article published on 01 June 2009

Generation of Humanized Mice for Analysis of Human Dendritic Cells

scientific article published in January 2016

Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation

scientific article published on 01 December 2019

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells

scientific article published on 01 November 2018

HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice

scientific article

HTLV-1 propels thymic human T cell development in “human immune system” Rag2-/- IL-2R γc-/- Mice.

scientific article published on 6 June 2011

Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice

scientific article published in 2013

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.

scientific article published on 24 March 2016

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

scientific article

Human adaptive immune system Rag2-/-gamma(c)-/- mice

scientific article

Human hemato-lymphoid system mice: current use and future potential for medicine

scientific article

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

scientific article

Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges

Humanised mouse models for haematopoiesis and infectious diseases

scientific article published on 9 November 2017

Humanized hemato-lymphoid system mice

scientific article

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

scientific article published on July 2009

Humanized mice: are we there yet?

scientific article published on November 2005

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms

scientific article

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

scientific article published on 7 October 2007

Impact of a Patient Blood Management monitoring and feedback programme on allogeneic blood transfusions and related costs

scientific article published on 25 August 2019

Impact of inflammation on early hematopoiesis and the microenvironment

scientific article published on 30 May 2017

Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs

scientific article published on 11 August 2015

Improvement of relative survival in elderly patients with acute myeloid leukaemia emerging from population-based cancer registries in Switzerland between 2001 and 2013.

scientific article published on 6 December 2017

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

scientific article published on 21 June 2011

In vitro-differentiated T/natural killer-cell progenitors derived from human CD34+ cells mature in the thymus.

scientific article

In vivo divisional tracking of hematopoietic stem cells ⬇️

scientific article published on August 1, 2012

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth

scientific article published on 22 August 2017

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

scientific article

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

scientific article published in 2021

Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?

scientific article

Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity

scientific article

Instructive cytokine signals in dendritic cell lineage commitment

scientific article published on March 2010

Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow

scientific article published in January 2010

LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance

scientific article published on 11 November 2015

Langerhans cells renew in the skin throughout life under steady-state conditions

scientific article published on 4 November 2002

Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS

scientific article published on 04 February 2020

Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice

scientific article published on 22 April 2015

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

scientific article published on 01 November 2019

Long-Term Follow-Up of Antibody Titers Against Measles, Mumps, and Rubella in Recipients of Allogenic Hematopoietic Cell Transplantation

scientific article published on 01 November 2019

Lymphocyte development from hematopoietic stem cells.

scientific article

Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis.

scientific article

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

scientific article

Macrophage tolerance: CD47–SIRP-α–mediated signals matter

Marginal Zone Lymphoma Complicated by Protein Losing Enteropathy

scientific article published on 9 November 2016

Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling

scientific article

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.

scientific article published on 10 October 2016

Mobilization of Hematopoietic Progenitor Cells with Standard- or Reduced-Dose Filgrastim after Vinorelbine in Multiple Myeloma Patients: A Randomized Prospective Single-Center Phase II Study

scientific article published on 12 December 2017

Modelling of a genetically diverse evolution of Systemic Mastocytosis with Chronic Myelomonocytic Leukemia (SM-CMML) by Next Generation Sequencing

scientific article published on 11 July 2014

Molecular Minimal Residual Disease in Acute Myeloid Leukemia

Mouse Models for Human Hemato-Lymphopoiesis

Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

scientific article published on 18 November 2021

Myasthenia gravis and tumor necrosis factor β polymorphisms: linkage disequilibrium but no association beyond HLA-B8

scientific article published on 01 October 1998

Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.

scientific article

NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis.

scientific article published on 28 August 2017

NLRP3 Controls the Development of Gastrointestinal CD11b+ Dendritic Cells in the Steady State and during Chronic Bacterial Infection

scientific article

Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness

scientific article published on 19 July 2017

Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice

scientific article published on 19 August 2016

Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma

scientific article published on 01 October 2019

Plasmacytoid dendritic cells: origin matters

scientific article

Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components

scientific article published on 08 September 2009

Prospective isolation of human clonogenic common myeloid progenitors

scientific article

Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy.

scientific article

R-hyper-CVAD versus R-CHOP/cytarabine with high-dose therapy and autologous haematopoietic stem cell support in fit patients with mantle cell lymphoma: 20 years of single-center experience

scientific article published on 16 November 2017

Regulation of Inflammation- and Infection-Driven Hematopoiesis

scientific article published on 16 February 2017

Renaissance for mouse models of human hematopoiesis and immunobiology

scientific article published on October 2009

Response to Tyrosine Kinase Inhibitors in Myeloproliferative Neoplasia with 8p11 Translocation and CEP110-FGFR1 Rearrangement

scientific article published on 27 February 2017

Reversible skeletal disease and high fluoride serum levels in hematologic patients receiving voriconazole

scientific article published on 2 August 2012

Rituximab consolidation after high-dose chemotherapy and autologous blood stem cell transplantation in follicular and mantle cell lymphoma: a prospective, multicenter phase II study

scientific article published on 01 November 2004

Safety and efficacy of cryopreserved autologous platelet concentrates in HLA-alloimmunized patients with hematologic malignancies.

scientific article

Selective CD117+ HSC exchange therapy

scientific article published on 01 May 2019

Sensing and translation of pathogen signals into demand-adapted myelopoiesis

scientific article

Sustained remission of an extensive monoclonal, Epstein-Barr virus-associated diffuse large B cell lymphoma in a kidney-pancreas transplant recipient

scientific article published in March 2002

Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents

scientific article published on 29 June 2020

The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma

scientific article published on 12 September 2019

The STATs on dendritic cell development

scientific article published on April 2008

The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis

scientific article published on 22 May 2009

The tumor suppressive TGF-β/SMAD1/S1PR2 signaling axis is recurrently inactivated in diffuse large B-cell lymphoma

scientific article published on 3 April 2018

Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML.

scientific article published on 3 January 2017

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

scientific article

Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo

scientific article published on 12 June 2008

Ultra-sensitive proteome profiling of FACS-isolated cell populations by data-independent acquisition-MS: Application to human hematopoietic stem and progenitor cells

scientific article

iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

scientific article published on 26 December 2019

inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice

scientific article published on 31 August 2016

sIL2R ratio as early marker for response in hairy cell leukemia and the prognostic relevance of IL28B genotype to interferon-α therapy.

scientific article published on 18 February 2017

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