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List of works by Anna Krook

A balancing act of optimising insulin dose and insulin sensitivity in type 1 diabetes

scientific article published on 8 August 2011

Acute exercise remodels promoter methylation in human skeletal muscle.

scientific article

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients

scientific article published on 02 January 2016

Altered content of AMP-activated protein kinase isoforms in skeletal muscle from spinal cord injured subjects

scientific article published on 10 September 2013

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

scientific article published on 12 April 2017

Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass

scientific article published on 28 January 2014

Altered response of skeletal muscle to IL-6 in type 2 diabetic patients

scientific article published on 18 October 2012

Analysis of insulin signaling pathways through comparative genomics. Mapping mechanisms for insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus.

scientific article

Arginase inhibition reduces infarct size via nitric oxide, protein kinase C epsilon and mitochondrial ATP-dependent K+ channels

scientific article published on 9 May 2013

Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7.

scientific article published on 8 October 2013

Can the liver X receptor work its magic in skeletal muscle too?

scientific article published in May 2006

Changes in gene expression in responders and nonresponders to a low-intensity walking intervention

scientific article published on 20 March 2015

Chloroquine Extends the Lifetime of the Activated Insulin Receptor Complex in Endosomes ⬇️

scientific article published on October 24, 1997

Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle

scientific article published on 14 December 2018

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity

scientific article

Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes

scientific article published on 5 October 2012

ContRac1ion-mediated glucose uptake: a central role for Rac1.

scientific article published on April 2013

Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects

scientific article published in May 2011

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

scientific article published in March 2011

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes

scientific article published on 4 March 2016

Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes

scientific article published in 2022

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

scientific article published in February 2008

ERK1/2 mediates insulin stimulation of Na(+),K(+)-ATPase by phosphorylation of the alpha-subunit in human skeletal muscle cells

scientific article published on 6 April 2004

Effect of serum replacement with plysate on cell growth and metabolismin primary cultures of human skeletal muscle

scientific article

Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance

scientific article published on 01 January 2013

Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle

scientific article published on 01 November 2000

Effects of sleeping with reduced carbohydrate availability on acute training responses

scientific article published on 25 June 2015

Endothelin-1 reduces glucose uptake in human skeletal muscle in vivo and in vitro

scientific article published on 15 June 2011

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

scientific article published on 12 October 2021

Endurance training increases stimulation of uncoupling of skeletal muscle mitochondria in humans by non-esterified fatty acids: an uncoupling-protein-mediated effect?

scientific article published on November 2000

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery

scientific article published on 13 November 2014

Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.

scientific article published on 30 April 2005

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

scientific article published on 29 December 2012

Exercise and the Treatment of Diabetes and Obesity

scientific article published in December 2008

Exercise and the treatment of diabetes and obesity

scientific article

Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport.

scientific article

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle

scientific article

Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects

scientific article published on 11 September 2002

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

scientific article

Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes

scientific article

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention ⬇️

scientific article published on 7 September 2022

Glucocorticoid-mediated effects on metabolism are reversed by targeting 11 beta hydroxysteroid dehydrogenase type 1 in human skeletal muscle

scientific article published on March 2009

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.

scientific article published on 25 December 2015

Homozygous mutation in the insulin receptor

scientific article published in August 1996

Human skeletal muscle cell differentiation is associated with changes in myogenic markers and enhanced insulin-mediated MAPK and PKB phosphorylation.

scientific article published on April 2004

Human skeletal muscle fibre type variations correlate with PPAR alpha, PPAR delta and PGC-1 alpha mRNA.

scientific article

IL-6 and metabolism-new evidence and new questions

scientific article published on July 2008

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

scientific article published on 14 February 2022

Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats

scientific article published in December 1997

Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression

scientific article published on 15 October 2019

Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance

scientific article published on 19 June 2015

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content.

scientific article

Insulin action in skeletal muscle from patients with NIDDM.

scientific article published in May 1998

Insulin signalling and resistance in patients with chronic heart failure

scientific article published on 9 May 2003

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

scientific article published in August 1998

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects

scientific journal article

Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle

scientific article published on 15 March 2007

Low-intensity exercise increases skeletal muscle protein expression of PPARδ and UCP3 in type 2 diabetic patients

scientific article published on 01 November 2006

MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways

scientific article published on 11 February 2004

Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle

scientific article

Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle

scientific article published on 01 October 2001

Maternal obesity legacy: exercise it away!

scientific article published in January 2016

Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise

article

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus

scientific article published on 03 August 2011

Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice

scientific article published on 22 April 2019

Molecular mechanisms of inherited insulin resistance.

scientific article published on September 1997

Molecular mechanisms underlying insulin resistance in skeletal muscle

scientific article published on November 2010

Molecular scanning of the insulin receptor gene in women with polycystic ovarian syndrome

scientific article published in May 1996

Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance: detection and functional analysis of a naturally occurring mutation in a YMXM motif.

scientific article

Mutant insulin receptors in syndromes of insulin resistance

scientific article published in January 1996

Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

scientific article published in September 2009

One step forward for exercise

scientific article published on 27 November 2015

Phosphorylation of the Na+,K+-ATPase in skeletal muscle: potential mechanism for changes in pump cell-surface abundance and activity.

scientific article published in April 2003

Prenatal analysis of the insulin receptor gene in a family with leprechaunism

scientific article published in July 1995

Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake

scientific article published on 18 May 2004

RNA interference-mediated reduction in GLUT1 inhibits serum-induced glucose transport in primary human skeletal muscle cells

scientific article published in July 2003

Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro

scientific article

Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta

scientific article published on September 2009

Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects

scientific article

Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

scientific article

Role of interleukin-6 signalling in glucose and lipid metabolism

scientific article published on January 2008

Sending the signal: molecular mechanisms regulating glucose uptake

scientific article published in July 2004

Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle

scientific article published in December 2006

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression

scientific article

Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA.

scientific article published on 31 March 2009

Strenuous physical exercise adversely affects monocyte chemotaxis

scientific article published on 26 October 2010

Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle

scientific journal article

TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle

scientific article published on March 2015

TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle

scientific article published in September 2015

TXNIP regulates peripheral glucose metabolism in humans

scientific article

Targeting adipose tissue angiogenesis to enhance insulin sensitivity

scientific article

Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells

scientific article

Time to Look Back and to Look Forward

scientific article published on 01 April 2014

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

scientific article published on 24 January 2020

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin's Metabolic and Mitogenic Effects ⬇️

scientific article published in Journal of Biological Chemistry

Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients ⬇️

scientific article published on September 1, 1998

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation

Weight loss after gastric bypass surgery in human obesity remodels promoter methylation

scientific article published on 11 April 2013

miRNA let-7 expression is regulated by glucose and TNF-α by a remote upstream promoter

scientific article published on 16 September 2015

microManaging glucose and lipid metabolism in skeletal muscle: Role of microRNAs

scientific article published on 13 May 2016

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

scientific article

siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle

scientific article published on 28 April 2008

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