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List of works by James N. Sleigh

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

scientific article

A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia

scientific article published on 11 February 2016

A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

scientific article published on 24 June 2020

ALS mice carrying pathological mutant TDP-43, but not mutant FUS, display axonal transport defects in vivo

Aligned electrospun fibers for neural patterning.

scientific article published on 8 January 2018

Antisense oligonucleotides and other genetic therapies made simple.

scientific article published on 17 February 2018

Axonal transport and neurological disease

scientific article published on 26 September 2019

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy

scientific journal article

Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects ⬇️

scientific article published on October 28, 2010

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

scientific article published on 08 May 2019

Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

scientific article published on 23 July 2020

Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.

scientific article published on 13 May 2015

Engineered method for directional growth of muscle sheets on electrospun fibers.

scientific article published on 21 December 2017

In Vivo Imaging of Anterograde and Retrograde Axonal Transport in Rodent Peripheral Nerves

scientific article published on 01 January 2020

In vivo imaging of axonal transport in murine motor and sensory neurons.

scientific article

Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics

scientific article

Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

scientific article published on 17 March 2020

Methodological advances in imaging intravital axonal transport

scientific article published on March 2017

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes

scientific article published on 01 March 2020

Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles.

scientific article

Morphological variability is greater at developing than mature mouse neuromuscular junctions

scientific article published on 13 June 2020

Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

scientific article published on 7 December 2017

NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease

scientific article

Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice

scientific article

Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo

scientific article published on 01 November 2019

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular development and homeostasis

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis

scientific article published on 23 August 2017

Older but not slower: aging does not alter axonal transport dynamics of signalling endosomes in vivo

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

scientific article published on 24 October 2013

Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy

scientific article published on 22 February 2018

Sensory neuron fate is developmentally perturbed by Gars mutations causing human neuropathy

Spinal muscular atrophy at the crossroads of basic science and therapy.

scientific article

Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d.

scientific article published in March 2016

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

scientific article

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy ⬇️

scientific article published on July 1, 2011

The evolution of the axonal transport toolkit

scientific article published on 28 November 2019

Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations.

scientific article

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy

scientific article published on 01 October 2018

Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy

scientific article published on 13 January 2016

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