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List of works by Akihide Yoshimi

A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination

scientific article published on 29 January 2019

A role for RUNX1 in hematopoiesis and myeloid leukemia.

scientific article published on 24 April 2013

ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells.

scientific article published on 6 February 2018

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors ⬇️

scientific article published on October 21, 2011

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

scientific article

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

scientific article published on 25 November 2019

Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation

scientific article published on 14 June 2016

Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis

scientific article published on 08 July 2019

An indeterminate result of QuantiFERON-TB Gold In-Tube for miliary tuberculosis due to a high level of IFN-γ production

scientific article published on 31 January 2014

Autoimmune neutropenia preceding Helicobacter pylori-negative MALT lymphoma with nodal dissemination

scientific article

Chronic myelomonocytic leukemia presenting severe uterine hemorrhage due to uterine infiltration of leukemic cells and early-stage endometrial adenocarcinoma

scientific article published on 19 April 2009

Comparison of garenoxacin with levofloxacin as antimicrobial prophylaxis in acute myeloid leukemia

scientific article

Conventional allogeneic hematopoietic stem cell transplantation for lymphoma may overcome the poor prognosis associated with a positive FDG-PET scan before transplantation.

scientific article published in June 2008

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

scientific article published on 02 October 2019

Defining risk in MDS over time

scientific article published in August 2016

Development of hairy cell leukemia in familial platelet disorder with predisposition to acute myeloid leukemia

scientific article

Efficacy of pleural biopsy for diagnosis of pleural effusion due to chronic GVHD after hematopoietic stem cell transplantation

scientific article published on 09 June 2012

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells

scientific article published on 29 December 2010

Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

scientific article published on 21 April 2014

Evi1 forms a bridge between the epigenetic machinery and signaling pathways.

scientific article published on July 2011

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity ⬇️

scientific article published on November 14, 2011

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

scientific article published on 2 February 2011

Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

scientific article published on 31 May 2017

Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele

scientific article published on 5 February 2016

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.

scientific article published on 19 February 2018

Hemoperitoneum due to spontaneous rupture of the left gastroepiploic artery in a patient with hemophilia A.

scientific article

Hemorrhagic cystitis in a patient receiving gemtuzumab ozogamicin for relapsed acute promyelocytic leukemia after cord blood transplantation

scientific article published on 03 April 2008

Hepatocellular carcinoma in cirrhotic liver with graft-versus-host disease

scientific article published on 01 September 2012

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene

article published in the Proceedings of the National Academy of Sciences of the United States of America

Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16.

scientific article

JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2.

scientific article

Key roles of histone methyltransferase and demethylase in leukemogenesis.

scientific article published on February 2011

Modified ESHAP regimen for relapsed/refractory T cell lymphoma: a retrospective analysis

scientific article published on 17 February 2015

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

scientific article published on 02 May 2016

Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins

scientific article published on 10 November 2016

Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization

scientific article published on 18 March 2020

Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies

scientific article published on 06 August 2018

Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells

scientific article

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity

scientific article published on 02 January 2014

Primary cutaneous anaplastic large cell lymphoma with leg involvement: a case report and review of 11 cases.

scientific article

Prognostic factors of Erdheim-Chester disease: a nationwide survey in Japan

scientific article published on 05 July 2018

ProteomeGenerator: A framework for comprehensive proteomics based on de novo transcriptome assembly and high-accuracy peptide mass spectral matching

scientific article published on 19 October 2018

Recurrent CDC25C mutations drive malignant transformation in FPD/AML.

scientific article

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

scientific article published on 16 August 2017

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML.

scientific article published on 2 June 2017

Safety of high-dose micafungin for patients with hematological diseases

scientific article published on 07 March 2014

Single-cell gene expression analysis reveals clonal architecture of blast-phase chronic myeloid leukaemia

scientific article published on 08 January 2014

Spectrum of clinical and genetic features of patients with inherited platelet disorder with suspected predisposition to hematological malignancies: a nationwide survey in Japan

scientific article

Spliceosomal disruption of the non-canonical BAF complex in cancer

scientific article published on 09 October 2019

Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.

scientific article published on 2 May 2017

Successful Control of Carcinoma of Unknown Primary with Axitinib, a Novel Molecular-Targeted Agent: A Case Report

scientific article published on 18 August 2015

Successful allogeneic stem cell transplantation for Lennert lymphoma.

scientific article published on 6 December 2012

Successful engraftment following HLA-mismatched cord blood transplantation for patients with anti-HLA Abs

scientific article published on 24 March 2008

Successful hematopoietic stem cell transplantation from an HLA-identical sibling in a patient with aplastic anemia after HLA-haploidentical living-related liver transplantation for fulminant hepatitis

scientific article published on 01 March 2009

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

article

Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis

scientific article

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

scientific article published on 21 February 2019

Targeting mRNA Decapping in AML.

scientific article published in March 2018

The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model

scientific article published in August 2013

The shortest isoform of C/EBPβ, liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model.

scientific article published in April 2013

Transformation of follicular lymphoma in the retroperitoneal muscles demonstrated by CT-guided needle biopsy of FDG-avid lesions; case series

scientific article published on 15 December 2013

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate

scientific article published in Scientific Reports

[Development of molecular targeted therapy for hematological disorder in the era of genomic drug discovery]

[Effective treatment with rituximab in two patients with Waldenström macroglobulinemia].

scientific article

[Leukemia stem cell and clonal evolution]

[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]

scientific article published on 01 December 2006

miR-133 regulates Evi1 expression in AML cells as a potential therapeutic target

scientific article

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