List of works - Karl E Kadler

3-D ultrastructure and collagen composition of healthy and overloaded human tendon: evidence of tenocyte and matrix buckling

scientific article

4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease

article

A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation

scientific article published on 17 February 2006

A structure-based extracellular matrix expansion mechanism of fibrous tissue growth

scientific article published on 20 May 2015

Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis

scientific article

Active Negative Control of Collagen Fibrillogenesisin Vivo

scientific article published on 19 February 2008

Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model

scientific article published on 24 July 2018

Ageing changes in the tensile properties of tendons: influence of collagen fibril volume fraction.

scientific article

An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery ⬇️

scientific article published on August 22, 2010

Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers

scientific article

Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture.

scientific article

Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity

scientific article (publication date: 16 May 2003)

Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.

scientific article published on 21 November 2000

Cellular homeostatic tension and force transmission measured in human engineered tendon

article

Changes in S100 Proteins Identified in Healthy Skin following Electrical Stimulation

scientific article published on 01 July 2018

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke

scientific article

Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix

scientific article

Circadian control of the secretory pathway maintains collagen homeostasis

scientific article published on 06 January 2020

Collagen Fibril Assembly and Function

scientific article published on 21 March 2018

Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens

scientific journal article

Collagen XXVII organises the pericellular matrix in the growth plate

scientific journal article

Collagen fibril biosynthesis in tendon: a review and recent insights.

scientific article

Collagens at a glance

scientific article published in June 2007

Deletion of Epidermal Growth Factor-like Domains Converts Mammalian Tolloid into a Chordinase and Effective Procollagen C-proteinase

scientific article published in Journal of Biological Chemistry

Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology

scientific article published on 12 September 2016

Design and synthesis of acidic dipeptide hydroxamate inhibitors of procollagen C-proteinase

scientific article published on 01 September 2000

Dynamic High-Sensitivity Quantitation of Procollagen-I by Endogenous CRISPR-Cas9 NanoLuciferase Tagging

scientific article published on 10 September 2020

ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

scientific article published on February 2016

Echinoderm collagen fibrils grow by surface-nucleation-and-propagation from both centers and ends

scientific article published on 01 July 2000

Electron microscope 3D reconstruction of branched collagen fibrils in vivo.

scientific article published on 14 April 2009

Electron microscopy in cell-matrix research

scientific article published on 01 May 2008

Electron microscopy of collagen fibril structure in vitro and in vivo including three-dimensional reconstruction.

scientific article published on January 2008

Enhanced Islet Cell Nucleomegaly Defines Diffuse Congenital Hyperinsulinism in Infancy but Not Other Forms of the Disease

scientific article published on June 2016

Evidence of structurally continuous collagen fibrils in tendons

scientific article published on 4 January 2017

Expression of an engineered form of recombinant procollagen in mouse milk

scientific article published on 01 April 1999

Fell Muir Lecture: Collagen fibril formation in vitro and in vivo.

scientific article

Fibrin gels exhibit improved biological, structural, and mechanical properties compared with collagen gels in cell-based tendon tissue-engineered constructs

scientific article

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin

scientific article published on 8 April 2016

First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles.

scientific article

Giantin is required for intracellular N-terminal processing of type I procollagen

scientific article published on 04 May 2021

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock

scientific article

Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity

scientific article (publication date: 13 July 2001)

Identification of collagen fibril fusion during vertebrate tendon morphogenesis. The process relies on unipolar fibrils and is regulated by collagen-proteoglycan interaction

scientific article published on 01 January 2000

Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).

scientific article

Importance of the circadian clock in tendon development

scientific article published on 20 December 2018

Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.

scientific article published on 26 July 2016

Live imaging of collagen deposition during skin development and repair in a collagen I – GFP fusion transgenic zebrafish line

scientific article published on 06 June 2018

Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells

scientific article

Matrix metalloproteinase 14 is required for fibrous tissue expansion

scientific article published on 21 September 2015

Modification of the composition of articular cartilage collagen fibrils with increasing age.

scientific article

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development

scientific article published on 30 October 2017

Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane.

scientific article

Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network

scientific article (publication date: 16 May 2003)

Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein

scientific article (publication date: 8 November 2002)

Procollagen trafficking, processing and fibrillogenesis.

scientific article

Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP

scientific article published in September 2007

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid

scholarly article

STEM/TEM studies of collagen fibril assembly.

scientific article

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

scientific journal article

Serial block face-scanning electron microscopy: a tool for studying embryonic development at the cell-matrix interface

scientific article published on March 2015

Slow stretching that mimics embryonic growth rate stimulates structural and mechanical development of tendon-like tissue in vitro.

scientific article published on November 2011

Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase

scientific article

Synchronized mechanical oscillations at the cell-matrix interface in the formation of tensile tissue

article published in the Proceedings of the National Academy of Sciences of the United States of America

Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3.

scientific article

Targeted induction of endoplasmic reticulum stress induces cartilage pathology

scientific article

Targeting lysyl oxidase reduces peritoneal fibrosis.

scientific article published on 11 August 2017

Tendon development requires regulation of cell condensation and cell shape via cadherin-11-mediated cell-cell junctions.

scientific article published on 11 June 2007

Tendon functional extracellular matrix

scientific article published in June 2015

Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation

scientific article

Tenocyte contraction induces crimp formation in tendon-like tissue

scientific article

Tension is required for fibripositor formation

scientific article published on 09 February 2008

The 10+4 microfibril structure of thin cartilage fibrils

scientific article

The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2

scientific journal article

The supramolecular organization of fibrillin-rich microfibrils.

scientific article published on March 2001

Three-dimensional aspects of matrix assembly by cells in the developing cornea.

scientific article

Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury.

scientific article

Tip-mediated fusion involving unipolar collagen fibrils accounts for rapid fibril elongation, the occurrence of fibrillar branched networks in skin and the paucity of collagen fibril ends in vertebrates.

scientific article

Transcription factor EGR1 directs tendon differentiation and promotes tendon repair

scientific article

Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization.

scientific article published on 27 June 2013

List of works by Karl E Kadler

3-D ultrastructure and collagen composition of healthy and overloaded human tendon: evidence of tenocyte and matrix buckling

4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease

A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation

A structure-based extracellular matrix expansion mechanism of fibrous tissue growth

Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis

Active Negative Control of Collagen Fibrillogenesisin Vivo

Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model

Ageing changes in the tensile properties of tendons: influence of collagen fibril volume fraction.

An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery ⬇️

Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers

Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture.

Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity

Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.

Cellular homeostatic tension and force transmission measured in human engineered tendon

Changes in S100 Proteins Identified in Healthy Skin following Electrical Stimulation

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke

Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix

Circadian control of the secretory pathway maintains collagen homeostasis

Collagen Fibril Assembly and Function

Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens

Collagen XXVII organises the pericellular matrix in the growth plate

Collagen fibril biosynthesis in tendon: a review and recent insights.

Collagens at a glance

Deletion of Epidermal Growth Factor-like Domains Converts Mammalian Tolloid into a Chordinase and Effective Procollagen C-proteinase

Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology

Design and synthesis of acidic dipeptide hydroxamate inhibitors of procollagen C-proteinase

Dynamic High-Sensitivity Quantitation of Procollagen-I by Endogenous CRISPR-Cas9 NanoLuciferase Tagging

ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

Echinoderm collagen fibrils grow by surface-nucleation-and-propagation from both centers and ends

Electron microscope 3D reconstruction of branched collagen fibrils in vivo.

Electron microscopy in cell-matrix research

Electron microscopy of collagen fibril structure in vitro and in vivo including three-dimensional reconstruction.

Enhanced Islet Cell Nucleomegaly Defines Diffuse Congenital Hyperinsulinism in Infancy but Not Other Forms of the Disease

Evidence of structurally continuous collagen fibrils in tendons

Expression of an engineered form of recombinant procollagen in mouse milk

Fell Muir Lecture: Collagen fibril formation in vitro and in vivo.

Fibrin gels exhibit improved biological, structural, and mechanical properties compared with collagen gels in cell-based tendon tissue-engineered constructs

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin

First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles.

Giantin is required for intracellular N-terminal processing of type I procollagen

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock

Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity

Identification of collagen fibril fusion during vertebrate tendon morphogenesis. The process relies on unipolar fibrils and is regulated by collagen-proteoglycan interaction

Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).

Importance of the circadian clock in tendon development

Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.

Live imaging of collagen deposition during skin development and repair in a collagen I – GFP fusion transgenic zebrafish line

Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells

Matrix metalloproteinase 14 is required for fibrous tissue expansion

Modification of the composition of articular cartilage collagen fibrils with increasing age.

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development

Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane.

Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network

Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein

Procollagen trafficking, processing and fibrillogenesis.

Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid

STEM/TEM studies of collagen fibril assembly.

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

Serial block face-scanning electron microscopy: a tool for studying embryonic development at the cell-matrix interface

Slow stretching that mimics embryonic growth rate stimulates structural and mechanical development of tendon-like tissue in vitro.

Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase

Synchronized mechanical oscillations at the cell-matrix interface in the formation of tensile tissue

Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3.

Targeted induction of endoplasmic reticulum stress induces cartilage pathology

Targeting lysyl oxidase reduces peritoneal fibrosis.

Tendon development requires regulation of cell condensation and cell shape via cadherin-11-mediated cell-cell junctions.

Tendon functional extracellular matrix

Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation

Tenocyte contraction induces crimp formation in tendon-like tissue

Tension is required for fibripositor formation

The 10+4 microfibril structure of thin cartilage fibrils

The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2

The supramolecular organization of fibrillin-rich microfibrils.

Three-dimensional aspects of matrix assembly by cells in the developing cornea.

Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury.

Tip-mediated fusion involving unipolar collagen fibrils accounts for rapid fibril elongation, the occurrence of fibrillar branched networks in skin and the paucity of collagen fibril ends in vertebrates.

Transcription factor EGR1 directs tendon differentiation and promotes tendon repair

Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization.