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List of works by Matthias A. Karajannis

2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.

scientific article

A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma

scientific article published on 02 November 2020

A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma

scientific article published on March 2017

AT-30EFFECTS OF EVEROLIMUS ON MENINGIOMA GROWTH IN PATIENTS WITH NEUROFIBROMATOSIS TYPE 2.

scientific article published in November 2014

Abstract LB-172: Novel candidate oncogenic drivers in pineoblastoma

Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target

scientific article

BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.

scientific article

Clinical response to bevacizumab in schwannomatosis

scientific article

Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis.

scientific article published on 3 May 2017

Consensus recommendations for current treatments and accelerating clinical trials for patients with neurofibromatosis type 2

article

Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2.

scientific article

DNA Methylation-Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas

scientific article published on 06 October 2017

DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018

Differentiating high and low grade pediatric brain tumors using diffusional kurtosis imaging

EMBR-02. RECURRENT HOMOZYGOUS DELETION OF DROSHA AND MICRODUPLICATION OF PDE4DIP CONTAINING THE ANCESTRAL DUF1220 DOMAIN IN PINEOBLASTOMA

EPT-16A PHASE 1 TRIAL OF LENALIDOMIDE PLUS RADIOTHERAPY IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMAS OR HIGH-GRADE GLIOMAS.

scientific article published on 30 May 2016

EPT-21EFFICACY OF EVEROLIMUS IN PEDIATRIC BRAIN TUMORS: A SINGLE-INSTITUTION PATIENT SERIES.

scientific article published on 30 May 2016

Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas.

scientific article

Epstein-Barr virus infection in Western European pediatric non-Hodgkin lymphomas ⬇️

scientific article published on December 1, 2003

Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers

scientific article published on 18 May 2022

Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells

scientific article published on 01 April 2005

GENE-06. DISTINCT MOLECULAR SUBGROUPS OF TUMORS OF THE PINEAL REGION CORRELATE WITH CLINICAL PARAMETERS AND GENETIC ALTERATIONS

scientific article published on 23 April 2019

GENE-13. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

scientific article published on 23 April 2019

GENO-20NOVEL CANDIDATE ONCOGENIC DRIVERS IN PINEOBLASTOMA.

scientific article

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

scientific article (publication date: May 2014)

Glioblastoma multiforme: State of the art and future therapeutics

scientific article published on 08 May 2014

HG-127ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMAS: A CLINICOPATHOLOGIC AND MOLECULAR PROFILE.

scientific article published on 30 May 2016

HG-73SAFETY AND FEASIBILITY OF A MULTI-INSTITUTIONAL PHASE II TRIAL INCOPORATING BIOPSY AND MOLECULARLY DETERMINED TREATMENT OF CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPG).

scientific article published on 30 May 2016

Heterogeneity within the PF-EPN-B ependymoma subgroup

article

Histone H3K36I mutation in a metastatic histiocytic tumor of the skull and response to sarcoma chemotherapy

scientific article published on 23 October 2019

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

scientific article

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

LG-46INFERIOR OUTCOME AND POOR RESPONSE TO CONVENTIONAL THERAPIES IN PEDIATRIC LOW-GRADE GLIOMAS HARBORING THE BRAF V600E MUTATION.

scientific article published on 30 May 2016

LG-67MIDBRAIN GLIOMAS: A LARGE SERIES OF CLINICALLY AND RADIOGRAPHICALLY HETEROGENEOUS TUMORS.

scientific article published on 30 May 2016

Letter to the Editor regarding clinical debate concerning treatment of pediatric LGG by Cooney et al

scientific article published on 16 July 2020

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.

scientific article published in October 2017

MB-17NOVEL CANDIDATE ONCOGENIC DRIVERS IN PINEOBLASTOMA.

scientific article

MPTH-59. ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMAS: A CLINICOPATHOLOGIC AND MOLECULAR PROFILE

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus

scientific article

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

scientific article published in March 2012

MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.

scientific article published on 15 November 2012

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

scientific article published on 25 November 2019

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

scientific article published on 31 October 2018

Mutant IDH1 and thrombosis in gliomas.

scientific article published on 23 September 2016

NEXT-GENERATION NEUROPATHOLOGY - IMPROVING DIAGNOSTIC ACCURACY FOR BRAIN TUMORS USING DNA METHYLATION ARRAY-BASED MOLECULAR PROFILING.

scientific article published in July 2014

NFM-11. PEDIATRIC MENINGIOMAS ARE MOLECULARLY DISTINCT FROM ADULT COUNTERPARTS

article published in 2018

Neurofibromatosis-related tumors: emerging biology and therapies

scientific article

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article

Noncarboplatin-induced Sensorineural Hearing Loss in a Patient With an Intracranial Nongerminomatous Germ Cell Tumor

scientific article published on 22 May 2014

Overexpression and activation of epidermal growth factor receptor in hemangioblastomas ⬇️

scientific article published on February 22, 2010

PDTM-38. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS

scientific article published on 6 November 2017

Patterns of relapse for children with localized intracranial ependymoma.

scientific article published on 6 March 2018

Pediatric Brain Tumors: An Update.

scientific article published on 23 May 2016

Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape

scientific article published on 24 August 2015

Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201

scientific article published on 27 August 2019

Pediatric high-grade glioma: biologically and clinically in need of new thinking

scientific article

Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas.

scientific article published on 4 December 2013

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

scientific article

Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas.

scientific article

Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation

scientific article published on 12 August 2016

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway.

scientific article

Pre-treatment lymphopenia and indication of tumor-induced systemic immunosuppression in medulloblastoma

scientific article published on 16 November 2017

Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors

scientific article published on 9 February 2018

Prospective Feasibility and Safety Assessment of Surgical Biopsy for Patients with Newly Diagnosed Diffuse Intrinsic Pontine Glioma.

scientific article

Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma.

scientific article published on 10 July 2010

R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma.

scientific article published on 24 December 2010

Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis

scientific article published on 18 April 2017

Recommendations for imaging tumor response in neurofibromatosis clinical trials

scientific article

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent ascites in a patient with low-grade astrocytoma and ventriculo-peritoneal shunt treated with the multikinase inhibitor sorafenib.

scientific article

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

scientific article published in Nature Communications

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Subgroup-specific outcomes of children with malignant childhood brain tumors treated with an irradiation-sparing protocol

scientific article published on 02 August 2019

Sustained imaging response and hearing preservation with low-dose bevacizumab in sporadic vestibular schwannoma

scientific article published on 01 June 2019

Synchronous mixed germ cell tumor of the pineal gland and suprasellar region with a predominant angiomatous component: a diagnostic challenge

scientific article published on 20 December 2008

TB-27SUBGROUP-SPECIFIC OUTCOMES OF CHILDREN WITH MALIGNANT CHILDHOOD BRAIN TUMORS TREATED WITH AN IRRADIATION-SPARING PROTOCOL.

scientific article

TR-13EFFECTS OF EVEROLIMUS ON MENINGIOMA GROWTH IN PATIENTS WITH NEUROFIBROMATOSIS TYPE 2.

scientific article published on 21 April 2015

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

The new kid on the block: suicide gene therapy to modulate cancer immunosurveillance for children with high-risk malignant brain tumors

scientific article published on 01 March 2019

The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis.

scientific article published on 24 April 2017

The promise of molecular profiling of choroid plexus tumors for diagnostic and prognostic stratification: where to go from here?

scientific article published on 22 March 2016

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

scientific article published on 20 July 2017

Treatment of pediatric brain tumors

scientific article published on December 2008

Treatment-related myelodysplastic syndrome after chemotherapy for childhood low-grade astrocytoma.

scientific article published in October 2006

Utility of MRI versus tumor markers for post-treatment surveillance of marker-positive CNS germ cell tumors.

scientific article published on 12 July 2016

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