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List of works by Stephan Stilgenbauer

17p deletion in chronic lymphocytic leukemia: risk stratification and therapeutic approach

scientific article published on April 2013

188Re or 90Y-labelled anti-CD66 antibody as part of a dose-reduced conditioning regimen for patients with acute leukaemia or myelodysplastic syndrome over the age of 55: results of a phase I-II study

scientific article published in August 2005

A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies

scientific article published on July 27, 2011

A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

scientific article

Abstract 2284: Dissecting signaling networks involved in the tumor-microenvironment crosstalk in chronic lymphocytic leukemia (CLL)

Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymp

scientific article published on 13 June 2016

Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia

scientific article published on 17 January 2006

Advances in the use of alemtuzumab in CLL.

scientific article published on January 2008

Advances in treating chronic lymphocytic leukemia

scientific article

Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer

Alemtuzumab consolidation in chronic lymphocytic leukaemia: a phase I/II multicentre trial

scientific article published on 9 November 2016

Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism

scholarly article

Allogeneic hematopoietic cell transplantation for high-risk CLL: 10-year follow-up of the GCLLSG CLL3X trial

scientific article published on 17 July 2017

Allogeneic hematopoietic cell transplantation for patients with TP53 mutant or deleted chronic lymphocytic leukemia: Results of a prospective observational study

scientific article published on 16 August 2020

Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European Group for Blood and Marrow Transplantation analysis

scientific article published on 18 August 2008

Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial

scientific article published in July 2010

Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis

scientific article

Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.

scientific article

Analysis of ITGB2 rare germ line variants in chronic lymphocytic leukemia

scientific article published on 19 October 2017

Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma

scientific article published on 24 April 2006

Anti-CD20 immunotherapy as a bridge to tolerance, after allogeneic stem cell transplantation for patients with chronic lymphocytic leukaemia: results of the CLLX4 trial

scientific article published on 12 March 2018

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach

article published in 2014

Associations of ofatumumab exposure and treatment outcomes in patients with untreated CLL receiving chemoimmunotherapy.

scientific article published on 7 July 2016

Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells ⬇️

scientific article published on April 11, 2013

Autoimmune conditions and chronic infections in chronic lymphocytic leukemia patients at diagnosis are associated with unmutated IgVH genes

scientific article published on 6 October 2008

Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma wor

scientific article

Autologous graft-versus-host disease-like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia

scientific article published on 25 May 2006

Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations

scientific article

BCL2-938C>A polymorphism and disease progression in chronic lymphocytic leukemia

scientific article published in November 2009

BIRC3 mutations in chronic lymphocytic leukemia - uncommon and unfavorable

scientific article published on 31 January 2020

BRAFmutations in chronic lymphocytic leukemia ⬇️

scientific article published on November 20, 2012

Bendamustine and rituximab in combination with lenalidomide in patients with chronic lymphocytic leukemia

scientific article published on 8 December 2015

Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group

scientific article

Bendamustine followed by obinutuzumab and venetoclax in chronic lymphocytic leukaemia (CLL2-BAG): primary endpoint analysis of a multicentre, open-label, phase 2 trial

scientific article published on 13 August 2018

Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group

scientific article

Bendamustine, followed by ofatumumab and ibrutinib in chronic lymphocytic leukemia (CLL2-BIO): primary endpoint analysis of a multicentre, open-label phase-II trial

scientific article published on 27 February 2020

Biological diversity and risk-adapted treatment of chronic lymphocytic leukemia ⬇️

scientific article published on September 1, 2010

Bone marrow transplantation nephropathy after an intensified conditioning regimen with radioimmunotherapy and allogeneic stem cell transplantation.

scientific article published in February 2006

CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B.

scientific article published in July 2010

CLL 17p deletion: more than 'miR'ly p53?

scientific article published on 01 August 2010

CLL and deletion 13q14: merely the miRs?

scientific article published on 01 March 2012

CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia

scientific article published on 19 December 2018

CLL2-BXX Phase II trials: sequential, targeted treatment for eradication of minimal residual disease in chronic lymphocytic leukemia

scientific article published on 21 February 2018

COVID-19 among fit patients with CLL treated with venetoclax-based combinations

scientific article published on 29 June 2020

Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy.

scientific article published in August 2002

Capillary electrophoretic analysis of genomic DNA methylation levels

scientific article

Cellular origin and pathophysiology of chronic lymphocytic leukemia

scientific article published on 22 October 2012

Characterization of an HLA-restricted and human cytomegalovirus-specific antibody repertoire with therapeutic potential

scientific article published on 16 April 2020

Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells

scientific article published on 18 August 2009

Chemoimmunotherapy in chronic lymphocytic leukemia

scientific article published on 01 December 2010

Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia

scientific article

Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.

scientific article

Chronic Lymphocytic Leukemia

scientific article published on 01 January 2004

Chronic Lymphocytic Leukemia With TP53 Aberrations: Breakthroughs and Challenges

scientific article published on 01 June 2017

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

scientific article published on 23 May 2017

Chronic Lymphocytic Leukemia: New Concepts for Future Therapy ⬇️

scientific article published on October 1, 2010

Chronic lymphocytic leukemia - genomics lead the way ⬇️

scientific article published on October 1, 2011

Chronic lymphocytic leukemia and 13q14: miRs and more

scientific article

Chronic lymphocytic leukemia and treatment resistance in cancer: the role of the p53 pathway

scientific article published on 21 December 2008

Clinical Practice Recommendations for Use of Allogeneic Hematopoietic Cell Transplantation in Chronic Lymphocytic Leukemia on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation

scientific article published on 19 September 2016

Clinical activity of abemaciclib in patients with relapsed or refractory mantle cell lymphoma - a phase II study

scientific article published on 07 May 2020

Clinical efficacy of immunochemotherapy with fludarabine, epirubicin and rituximab in the treatment for chronic lymphocytic leukaemia and prolymphocytic leukaemia ⬇️

scientific article published on August 23, 2011

Clinical roundtable monograph. New alternatives in CLL therapy: managing adverse events

scientific article published on August 2010

Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival

scientific article published on 01 August 2007

Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice

scientific article published on 05 March 2020

Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study

scientific article published on 09 April 2020

Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy

scientific article

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

scientific article published on 12 June 2018

Confirmation of the mantle-cell lymphoma International Prognostic Index in randomized trials of the European Mantle-Cell Lymphoma Network

scientific article published on 31 March 2014

Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues

scientific article published on 28 September 2018

Cryptic insertion of MYC exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of "MYC-negative" Burkitt lymphoma

scientific article published on 09 May 2019

DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing.

scientific article

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

scientific article published on 18 January 2016

DNA methylation of chronic lymphocytic leukemia with differential response to chemotherapy

scientific article published on 01 May 2020

Danish CLL2-Study revisited: FISH on a cohort with a 20-yr follow-up confirms the validity of the hierarchical model of genomic aberrations in chronic lymphocytic leukaemia

scientific article published on 19 March 2009

Delineation of distinct tumour profiles in mantle cell lymphoma by detailed cytogenetic, interphase genetic and morphological analysis

scientific article published on 28 June 2008

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies

scientific article published on 11 May 2010

Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial.

scientific article published on 30 July 2009

Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia

scientific article

Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia

scientific article published on 13 June 2019

Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes

scientific article

Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia

scientific article

Duplication of chromosome arms 9q and 11q: evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma

scientific article published on 01 January 2005

Early autologous stem cell transplantation for chronic lymphocytic leukemia: long-term follow-up of the German CLL Study Group CLL3 trial

scientific article published on 05 April 2012

Early treatment with FCR versus watch and wait in patients with stage Binet A high-risk chronic lymphocytic leukemia (CLL): a randomized phase 3 trial

scientific article published on 18 February 2020

Efficacy and Safety of Duvelisib Following Disease Progression on Ofatumumab in Patients with Relapsed/Refractory CLL or SLL in the DUO Crossover Extension Study

scientific article published on 21 January 2020

Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota

scientific article published on 22 April 2016

Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables

scientific article published on 25 April 2019

Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells

scientific article published on 14 November 2019

Epigenetic silencing of miR-708 enhances NF-κB signaling in chronic lymphocytic leukemia

scientific article

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

scientific article

Evaluation of 230 patients with relapsed/refractory deletion 17p chronic lymphocytic leukaemia treated with ibrutinib from 3 clinical trials

scientific article published on 05 June 2018

Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: Results of the CLL9 trial of the German CLL study group

scientific article published on 17 September 2015

Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes

scientific article

Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocytic leukemia revealed by quantitative expression analysis of cell cycle, activation, and apoptosis-associated genes

scientific article published on 02 May 2005

Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia

scientific article

Extracellular vesicles in chronic lymphocytic leukemia ⬇️

scientific article published on August 1, 2013

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL

scientific article published on 03 December 2018

Fatal Ophiostoma piceae infection in a patient with acute lymphoblastic leukaemia.

scientific article

Feasibility and safety of CD19 CAR T cell treatment for B-cell lymphoma relapse after allogeneic hematopoietic stem cell transplantation

scientific article published on 15 May 2020

Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia

scientific article published on 17 April 2019

Final results of EFC6663: a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia

scientific article

Final results of a multicenter phase 1 study of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia

scientific article

First demonstration of leukemia imaging with the proliferation marker 18F-fluorodeoxythymidine

scientific article

First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): an international, open-label, randomised, phase 3, non-inferiority tri

scientific article published on 20 May 2016

First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia

scientific article published on 15 July 2009

Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia

scientific article

Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial

scientific article published on 01 December 2020

Four-Factor Score for Outcome of Ibrutinib Treatment in Chronic Lymphocytic Leukemia: Prognostic Model for Risk Group Definition

scientific article published on 13 October 2020

From Biology to Therapy: The CLL Success Story

scientific article published on 09 February 2019

From pathogenesis to treatment of chronic lymphocytic leukaemia

scientific article published on 03 December 2009

Front-line treatment of CLL in the era of novel agents

scientific article published on 30 December 2016

Functional characterization of phospholipase C-γ mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder

article published in 2018

Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia

scientific article

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial

scientific article published on 20 March 2014

Genetic analysis of de novo CD5+ diffuse large B-cell lymphomas suggests an origin from a somatically mutated CD5+ progenitor B cell

scientific article published on 29 August 2002

Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter's syndrome)

scientific article published on September 2002

Genetics and risk-stratified approach to therapy in chronic lymphocytic leukemia

scientific article published on September 2007

Genetics of Chronic Lymphocytic Leukemia ⬇️

scientific article published on November 17, 2011

Genetics, gene expression, and targeted therapies in chronic lymphocytic leukemia

scientific article published on October 2006

Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions

scientific article published on 13 April 2004

Genomic Features: Impact on Pathogenesis and Treatment of Chronic Lymphocytic Leukemia

scientific article published on 26 January 2016

Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations

scientific article published on 26 March 2008

Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1 regulated transcription

scientific article published on 29 August 2019

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

scientific article published on 29 March 2019

Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia

scientific article

Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: implications of minimal residual disease measurement with quantitative PCR.

scientific article published on 17 June 2004

Guidelines for diagnosis, indications for treatment, response assessment and supportive management of chronic lymphocytic leukemia

scientific article published on 14 March 2018

High efficacy of venetoclax plus obinutuzumab in patients with complex karyotype and chronic lymphocytic leukemia

scientific article published on 01 March 2020

High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukemia

scientific article published in September 2007

High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial

scientific article

High-risk chronic lymphocytic leukemia in the era of pathway inhibitors: integrating molecular and cellular therapies

scientific article published on 11 July 2018

High-throughput detection of nuclear factor-kappaB activity using a sensitive oligo-based chemiluminescent enzyme-linked immunosorbent assay

scientific article published on July 2010

Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

scientific article published on 29 September 2020

How best to manage patients with chronic lymphocytic leuekmia with 17p deletion and/or TP53 mutation?

scientific article

Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase

scientific article published on 16 February 2017

Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens of primary central nervous system lymphoma

scientific article published on 24 September 2018

IG--positive neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas

scientific article published on 03 October 2018

IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia

scientific article published on 22 April 2019

IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

scientific article published on 11 February 2020

Ibrutinib for patients with relapsed or refractory chronic lymphocytic leukaemia with 17p deletion (RESONATE-17): a phase 2, open-label, multicentre study

scientific article published on 13 September 2016

Ibrutinib-resistant CLL: unwanted and unwonted!

scientific article

Idelalisib and rituximab in relapsed chronic lymphocytic leukemia

scientific article

Idelalisib or placebo in combination with bendamustine and rituximab in patients with relapsed or refractory chronic lymphocytic leukaemia: interim results from a phase 3, randomised, double-blind, placebo-controlled trial

scientific article

Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B cell-type diffuse large B-cell lymphoma

scientific article published on 16 July 2020

Immune modulatory agents in hematopoietic malignancies ⬇️

scientific article published on 08 June 2011

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification

scientific article published on June 2017

Immunoglobulin heavy chain variable gene usage and (super)-antigen drive in chronic lymphocytic leukemia

scientific article published on 12 January 2010

Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial

scientific article published on 8 July 2016

Importance of genetics in chronic lymphocytic leukemia ⬇️

scientific article published on March 23, 2011

Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2 ⬇️

scientific article published on December 6, 2010

Influence of obesity and gender on treatment outcomes in patients with chronic lymphocytic leukemia (CLL) undergoing rituximab-based chemoimmunotherapy

scientific article published on 14 November 2019

Insertion site of central venous catheter correlates with catheter-related infectious events in patients undergoing intensive chemotherapy

scientific article published on 23 July 2020

Interactions between comorbidity and treatment of chronic lymphocytic leukemia: results of German Chronic Lymphocytic Leukemia Study Group trials

scientific article

International Prognostic Score for Asymptomatic Early-stage Chronic Lymphocytic Leukemia

scientific article published on 08 April 2020

Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling

scientific article published on 14 April 2016

Lenalidomide maintenance after first-line therapy for high-risk chronic lymphocytic leukaemia (CLLM1): final results from a randomised, double-blind, phase 3 study

scientific article published on 12 September 2017

Lenalidomide reduces survival of chronic lymphocytic leukemia cells in primary cocultures by altering the myeloid microenvironment ⬇️

scientific article published on January 24, 2013

Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17 T helper cells

scientific article published on 30 November 2009

Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis ⬇️

scientific article published on December 7, 2010

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

scientific article published on 22 May 2019

Long Term Follow-up Data and Health-Related Quality of Life in Frontline Therapy of Fit Patients Treated With FCR Versus BR (CLL10 Trial of the GCLLSG)

scientific article published on 27 January 2020

Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia

scientific article published on 15 July 2019

Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results

scientific article

Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial

scientific article published on 20 October 2015

Loss of cooperativity of secreted CD40L and increased dose-response to IL4 on CLL cell viability correlates with enhanced activation of NF-kB and STAT6

scientific article published on 27 May 2014

MDM2 promotor polymorphism and disease characteristics in CLL

scientific article published on 25 August 2009

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

scientific article

MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma

scientific article published on 18 April 2019

MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells

scientific article

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

scientific article

Management of chronic lymphocytic leukemia

scientific article published on 01 January 2015

Managing high-risk CLL during transition to a new treatment era: stem cell transplantation or novel agents?

scientific article

Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

scientific article published on 18 March 2020

Microarray gene expression profiling of B-cell chronic lymphocytic leukemia subgroups defined by genomic aberrations and VH mutation status

scientific article published on 01 October 2004

Minimal Residual Disease Assessment Improves Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Partial Response: Comprehensive Analysis of Two Phase III Studies of the German CLL Study Group

scientific article published on 29 August 2016

Minimal Residual Disease Quantification Is an Independent Predictor of Progression-Free and Overall Survival in Chronic Lymphocytic Leukemia: A Multivariate Analysis From the Randomized GCLLSG CLL8 Trial ⬇️

scientific article published on February 13, 2012

Missing the notch in NOTCH1

scientific article published on 16 February 2013

Mode of progression after first line treatment correlates with outcome of chronic lymphocytic leukemia (CLL)

scientific article published on 08 July 2019

Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implications

scientific article published on May 2008

Molecular genetics and its clinical relevance

scientific article published in August 2004

Molecular imaging of proliferation in malignant lymphoma

scientific article published in November 2006

Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up

scientific article

More (on) prognostic factors in chronic lymphocytic leukemia

article published in 2009

Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL).

scientific article published on March 2010

Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLL

article

Mutations driving CLL and their evolution in progression and relapse

scientific article published on 14 October 2015

NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib

scientific article published on 18 September 2017

NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.

scientific article published on 2 July 2013

New lessons learned in T-PLL: results from a prospective phase-II trial with fludarabine-mitoxantrone-cyclophosphamide-alemtuzumab induction followed by alemtuzumab maintenance

scientific article published on 20 September 2018

No increased bleeding events in patients with relapsed chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma treated with idelalisib

scientific article published on 10 December 2020

Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling

scientific article published on 21 September 2020

Non-catalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells

scientific article published on 17 March 2020

Novel targeted treatment strategies for refractory chronic lymphocytic leukaemia ⬇️

scientific article published on August 1, 2011

Nurse-like cells show deregulated expression of genes involved in immunocompetence.

scientific article published on 25 May 2011

Obinutuzumab (GA101) for the treatment of chronic lymphocytic leukemia and other B-cell non-hodgkin's lymphomas: a glycoengineered type II CD20 antibody

scientific article

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

Obinutuzumab plus bendamustine in previously untreated patients with CLL: a subgroup analysis of the GREEN study

scientific article published on 27 April 2018

Obinutuzumab plus fludarabine and cyclophosphamide in previously untreated, fit patients with chronic lymphocytic leukemia: a subgroup analysis of the GREEN study

scientific article published on 27 August 2019

Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia

scientific article

Ofatumumab in poor-prognosis chronic lymphocytic leukemia: a phase IV, non-interventional, observational study from the European Research Initiative on Chronic Lymphocytic Leukemia

scientific article

Ofatumumab monotherapy in fludarabine-refractory chronic lymphocytic leukemia: final results from a pivotal study

scientific article published on 13 March 2015

Optimising outcomes for patients with chronic lymphocytic leukaemia on ibrutinib therapy: European recommendations for clinical practice.

scientific article published on 9 January 2018

Outcome of advanced chronic lymphocytic leukemia following different first-line and relapse therapies: a meta-analysis of five prospective trials by the German CLL Study Group (GCLLSG).

scientific article published on 27 August 2015

Outcome of patients aged 80 years or older treated for chronic lymphocytic leukaemia

scientific article published on 21 November 2018

Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia.

scientific article

Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia

scientific article published on 24 June 2013

Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL

scientific article published on 12 July 2019

P53 and microRNAs in chronic lymphocytic leukemia

PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia

scientific article published on 20 December 2018

PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia

scientific article published on 10 June 2014

Pathogenic complexity of gastric B-cell lymphoma

scientific article published on 01 August 2002

Phase 1 first-in-human trial of the anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia

scientific article published on 14 May 2019

Poor efficacy and tolerability of R-CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation

scientific article

Postibrutinib outcomes in patients with mantle cell lymphoma

scientific article

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

scientific article published on 29 July 2019

Profile of venetoclax and its potential in the context of treatment of relapsed or refractory chronic lymphocytic leukemia

scientific article published on 7 February 2017

Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern in Mantle-Cell Lymphoma: Results From Randomized Trials of the European Mantle Cell Lymphoma Network

scientific article

Prognostic and predictive factors in patients with chronic lymphocytic leukemia: relevant in the era of novel treatment approaches?

scientific article published on 10 February 2014

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax

scientific article published on 23 March 2020

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1

scientific article published on 09 January 2020

Prognostic impact of prevalent chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group (GCLLSG)

scientific article published on 26 December 2019

Prognostic markers and standard management of chronic lymphocytic leukemia

scientific article

Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group

scientific article published on 10 February 2020

Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab

scientific article published on 19 November 2018

Progranulin is a novel independent predictor of disease progression and overall survival in chronic lymphocytic leukemia

scientific article

Prolonged Course of COVID-19-Associated Pneumonia in a B-Cell Depleted Patient After Rituximab

scientific article published on 02 September 2020

Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes

scientific article published on 01 May 2007

Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk

scientific article

Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia

scientific article

Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients

scientific article

Quantitative gene expression deregulation in mantle-cell lymphoma: correlation with clinical and biologic factors

scientific article published on 11 June 2007

Rapid detection of ATM/p53 function with p27Kip FACS analysis: a novel diagnostic tool for chronic lympocytic leukemia?

scientific article published on 22 August 2016

Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia

scientific article published on 29 November 2019

Reduced-intensity conditioning followed by T-cell depleted allogeneic stem cell transplantation for patients with chronic myeloid leukaemia and minimal residual disease at the time of transplant: high risk of molecular relapse

scientific article published on 01 January 2007

Refractory chronic lymphocytic leukemia - new therapeutic strategies ⬇️

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Renal AA amyloidosis leading to early diagnosis and treatment of takayasu arteritis: a case report and review of the literature

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Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

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Response to Comment by Jonathan Weiss et al

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Response: Or both?

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Revolution of Chronic Lymphocytic Leukemia Therapy: the Chemo-Free Treatment Paradigm

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Risk categories and refractory CLL in the era of chemoimmunotherapy

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Risk stratification in chronic lymphocytic leukemia

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Role of Specific B-Cell Receptor Antigens in Lymphomagenesis

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SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL).

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Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter double-blinded randomized phase II trial

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Safety of obinutuzumab alone or combined with chemotherapy for previously untreated or relapsed/refractory chronic lymphocytic leukemia in the phase IIIb GREEN study

scholarly article by Véronique Leblond et al published November 2018 in Haematologica

Second-line therapies of patients initially treated with fludarabine and cyclophosphamide or fludarabine, cyclophosphamide and rituximab for chronic lymphocytic leukemia within the CLL8 protocol of the German CLL Study Group

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Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia

scientific article published on 19 March 2013

Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia

scientific article published on 28 November 2007

Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia

scientific article published on 25 March 2019

Soluble CD14 is a novel monocyte-derived survival factor for chronic lymphocytic leukemia cells, which is induced by CLL cells in vitro and present at abnormally high levels in vivo

scientific article published on 26 July 2010

Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia

scientific article published on 24 March 2010

Spontaneous regression of a plasmablastic lymphoma with MYC rearrangement

scientific article published on 01 July 2019

Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status

scientific article published on 29 November 2005

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

scientific article published on 01 January 2020

Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group

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Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis

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TBET-expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ-TCL1 mice

scientific article published on 14 November 2019

TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q ⬇️

scientific article published on August 8, 2012

TNF receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

scientific article published on 11 January 2018

TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics

scientific article published on 15 November 2018

TP53 mutation and survival in aggressive B cell lymphoma

scientific article published on 14 June 2017

TP53 mutation and survival in chronic lymphocytic leukemia

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TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial

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Targeted therapy in CLL: changing the treatment paradigm

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Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma

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Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia

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Telomere dysfunction and chromothripsis

scientific article published on 9 February 2016

Telomere length in mantle cell lymphoma

scientific article published on 14 December 2012

Telomere length in poor-risk chronic lymphocytic leukemia: associations with disease characteristics and outcome

scientific article published on 24 October 2017

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model

scientific article published on 22 August 2016

The CLL12 trial protocol: a placebo-controlled double-blind Phase III study of ibrutinib in the treatment of early-stage chronic lymphocytic leukemia patients with risk of early disease progression

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The MDM2 -309 T/G promoter single nucleotide polymorphism does not alter disease characteristics in chronic lymphocytic leukemia.

scientific article published on 27 May 2008

The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein

scientific article published on 19 August 2016

The VEGF receptor, neuropilin-1, represents a promising novel target for chronic lymphocytic leukemia patients

scientific article published on 29 March 2013

The gene expression signature associated with TP53 mutation/deletion in chronic lymphocytic leukaemia is dominated by the under-expression of TP53 and other genes on chromosome 17p

scientific article published on 30 October 2012

The impact of complex karyotype on the overall survival of patients with relapsed chronic lymphocytic leukemia treated with idelalisib plus rituximab

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The phase 3 DUO trial: duvelisib versus ofatumumab in relapsed and refractory CLL/SLL ⬇️

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The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status

scientific article published on 11 December 2003

Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

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Therapy with the FCR regimen does not overcome chronic lymphocytic leukemia biology: aberrant p53 expression predicts response and survival

scientific article published in October 2009

Time-to-progression after front-line fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy for chronic lymphocytic leukaemia: a retrospective, multicohort study

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Toward chemotherapy-free treatment of CLL

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Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes

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Treating chronic lymphocytic leukemia with thalidomide and lenalidomide

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Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial

scientific article published on 05 December 2019

Treatment resistance in chronic lymphocytic leukemia: the role of the p53 pathway

scientific article published on March 2009

Tumor-derived exosomes modulate PD-L1 expression in monocytes.

scientific article published in July 2017

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome.

scientific article published on 4 September 2013

Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

scientific article published on 28 July 2017

U-RT1 - A new model for Richter transformation

scientific article published on 11 December 2020

Understanding and Managing Ultra High-Risk Chronic Lymphocytic Leukemia ⬇️

scientific article published on January 1, 2010

Unmutated immunoglobulin variable heavy-chain gene status remains an adverse prognostic factor after autologous stem cell transplantation for chronic lymphocytic leukemia

scientific article published on 31 October 2002

V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia.

scientific article published in August 2002

VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome.

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Value of comparative genomic hybridization and fluorescence in situ hybridization for molecular diagnostics in multiple myeloma

scientific article published in July 2003

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions

scientific article published on 04 June 2019

Venetoclax and obinutuzumab in chronic lymphocytic leukemia

scientific article published on 21 March 2017

Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial

scientific article published in May 2018

Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia

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Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study

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Venetoclax plus bendamustine-rituximab or bendamustine-obinutuzumab in chronic lymphocytic leukemia: final results of a phase 1b study (GO28440)

scientific article published on 29 October 2020

Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (CLL14): follow-up results from a multicentre, open-label, randomised, phase 3 trial

scientific article published on 01 September 2020

Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia

scientific article published on 19 April 2019

Venetoclax: Targeting BCL2 in Hematological Cancers

scientific article published on 01 January 2018

Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extran

scientific article published on 17 October 2017

ZAP-70 methylation and expression status in chronic lymphocytic leukemia.

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miR-34a as part of the resistance network in chronic lymphocytic leukemia

scientific article published on 21 October 2008

miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells

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miRNAs involvement in the pathogenesis of Richter's syndrome

scholarly article by Katrien Van Roosbroeck et al published 8 November 2018 in Haematologica

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