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List of works by Cees van Kooten

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation

scientific article published on 29 January 2019

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells

scientific article published on 7 August 2017

A Novel Role of Complement Factor C1q in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8+ T Lymphocytes

article

A Restricted Role for FcγR in the Regulation of Adaptive Immunity.

scientific article published on 9 March 2018

A nonredundant role for canonical NF-κB in human myeloid dendritic cell development and function

scientific article published on 12 November 2010

A novel human IgA monoclonal antibody protects against tuberculosis

scientific article

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes

scientific article

A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility.

scientific article

A reverse translational study on the effect of rituximab, rituximab plus belimumab, or bortezomib on the humoral autoimmune response in SLE

scientific article published on 17 January 2020

Accelerated antibody-mediated graft loss of rodent pancreatic islets after pretreatment with dexamethasone-treated immature donor dendritic cells

scientific article published on 01 November 2012

Activation of the lectin pathway in murine lupus nephritis

scientific article published on 01 April 2005

Acute But Transient Release of Terminal Complement Complex After Reperfusion in Clinical Kidney Transplantation ⬇️

scientific article published on March 27, 2013

Adoptive transfer of primed CD4+ T-lymphocytes induces pattern of chronic allograft nephropathy in a nude rat model

scientific article published in April 2005

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

An Easy and Sensitive Method to Profile the Antibody Specificities of HLA-specific Memory B Cells

scientific article published on 01 April 2019

An increased polymeric IgA level is not a prognostic marker for progressive IgA nephropathy

scientific article published on 13 July 2004

Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes.

scientific article published on September 2004

Anti-tubular basement membrane antibodies and giant cell formation in a model of chronic renal allograft rejection

scientific article

Antibodies against mesangial cells in a rat model of chronic renal allograft rejection

scientific article published on 08 February 2005

Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat.

scientific article published on April 2002

Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy

scientific article published on 01 February 2005

Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy.

scientific article

Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients

scientific article

Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study

scientific article published on 24 January 2013

Bone marrow-derived mesenchymal stromal cells from patients with end-stage renal disease are suitable for autologous therapy

scientific article published on 16 February 2013

Both complement and IgG fc receptors are required for development of attenuated antiglomerular basement membrane nephritis in mice

scientific article published on 26 August 2009

Brain Death Enhances Activation of the Innate Immune System and Leads to Reduced Renal Metabolic Gene Expression

scientific article published on 01 September 2019

C1-Inhibitor Treatment Decreases Renal Injury in an Established Brain-Dead Rat Model

scientific article published on 21 July 2017

C4d staining in renal allograft biopsies with early acute rejection and subsequent clinical outcome

scientific article

CD40 ligand‐positive CD8+ T cell clones allow B cell growth and differentiation ⬇️

scientific article published on October 1, 1995

CD40L stimulation of rat dendritic cells specifically favors the IL-12/IL-10 ratio resulting in a strong T cell stimulatory capacity

scientific journal article

Chronic rejection in renal transplantation

scientific article published in 2004

Chronic renal allograft rejection: pathophysiologic considerations

scientific article

Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation

scientific article published on 05 August 2020

Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia

scientific article published on 4 May 2015

Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases

scientific article published on 19 November 2018

Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine

scientific article

Complement Activation in Patients With Diabetic Nephropathy.

scientific article

Complement activation by tubular cells is mediated by properdin binding

scientific article

Complement production and regulation by dendritic cells: molecular switches between tolerance and immunity

scientific article published on October 2008

Complexes of IgA with FcalphaRI/CD89 are not specific for primary IgA nephropathy

scientific article published on 01 February 2003

Compliments from complement: A fourth pathway of complement activation?

scientific article published on 02 September 2006

Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose

scientific article published in December 2003

Corticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development

scientific article

Counteracting dysfunction of regulatory T cells in organ transplantation

scientific article published on 22 June 2017

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury.

scientific article published on 10 April 2017

Cross-linking of antigen receptor via Ig-β (B29, CD79b) can induce both positive and negative signals in CD40-activated human B cells ⬇️

scientific article published on 01 December 1997

Culture medium used during small interfering RNA (siRNA) transfection determines the maturation status of dendritic cells

scientific article published on 17 January 2020

Demonstration of secretory IgA in kidneys of patients with IgA nephropathy

scientific article published on 02 June 2007

Dendritic cell and macrophage subsets in the handling of dying cells

scientific article published on 5 July 2006

Dendritic cells and complement: at the cross road of innate and adaptive immunity

scientific article published on June 2004

Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities

scientific article published on January 2011

Dendritic cells of IgA nephropathy patients have an impaired capacity to induce IgA production in naïve B cells

scientific article published in October 2005

Deposition of IgA in primary IgA nephropathy: it takes at least four to tango

scientific article published on 12 December 2012

Dexamethasone increases ROS production and T cell suppressive capacity by anti-inflammatory macrophages

article

Diabetic nephropathy alters circulating long noncoding RNA Levels that normalize following simultaneous pancreas-kidney transplantation

scientific article published on 30 April 2020

Dietary restriction and fasting downregulate complement activity.

scientific article published in June 2012

Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1.

scientific article published on 27 October 2014

Differential distribution and phenotype of decidual macrophages in preeclamptic versus control pregnancies

scientific article

Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy

scientific article published on 18 October 2006

Editorial: Kidney Transplantation and Innate Immunity

scientific article published on 14 October 2020

Effect of Anti‐Neutrophil Cytoplasmic Antibodies on Proteinase 3‐Induced Apoptosis of Human Endothelial Cells ⬇️

scientific article published on July 1, 1998

Effective targeting of pathogens to neutrophils via chimeric surfactant protein D/anti-CD89 protein

scientific article published in April 2004

Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin

scientific article

Elevated intragraft expression of innate immunity and cell death-related markers is a risk factor for adverse graft outcome

scientific article published on 20 February 2018

Emerging biomarkers in renal damage

scientific article published on 3 September 2014

Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury-induced inflammation and fibrosis

scientific article published on 21 June 2018

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA.

scientific article published on 30 March 2018

Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.

scientific article

Fas ligation induces apoptosis of CD40-activated human B lymphocytes ⬇️

scientific article published on November 1, 1995

Fc alpha RI/CD89 circulates in human serum covalently linked to IgA in a polymeric state

scientific article published on 01 February 2002

Fc receptor gamma chain residues at the interface of the cytoplasmic and transmembrane domains affect association with FcalphaRI, surface expression, and function

scientific article published on 19 April 2004

Functional Role of CD40 and Its Ligand ⬇️

scientific article published on August 1, 1997

Functional assessment of mouse complement pathway activities and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury.

scientific article published on 28 February 2015

Functional modulation of dendritic cells to suppress adaptive immune responses

scientific article

Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome

scientific article published on 05 December 2006

Generation and characterization of a novel anti-rat CD40L antibody with inhibitory activities in vitro and in vivo

scientific journal article

Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease

scientific article published on 10 May 2006

Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1.

scientific article published on March 2003

HLA monomers as a tool to monitor indirect allorecognition

scientific article

Half a century of Dutch transplant immunology

scientific article published on 18 October 2014

Handbook of experimental pharmacology "dendritic cells": the use of dexamethasone in the induction of tolerogenic DCs.

scientific article published on January 2009

Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity.

scientific article

Highly Sensitive Flow Cytometric Detection of Residual B-Cells After Rituximab in Anti-Neutrophil Cytoplasmic Antibodies-Associated Vasculitis Patients

scientific article published on 15 December 2020

Human Bone Marrow- and Adipose Tissue-derived Mesenchymal Stromal Cells are Immunosuppressive In vitro and in a Humanized Allograft Rejection Model.

scientific article

Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation

scientific article published in January 2002

Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages

scientific article published on 01 June 2007

Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells

scientific article

Human renal epithelial cells produce the long pentraxin PTX3.

scientific article published in February 2005

Human renal fibroblasts generate dendritic cells with a unique regulatory profile

scientific article

Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members.

scientific article

Human transferrin allows efficient IgE production by anti-CD3-stimulated human lymphocytes at low cell densities ⬇️

scientific article published on February 1, 1991

IL-10-producing macrophages preferentially clear early apoptotic cells

scientific article published on 23 February 2006

Identification of a novel CD40 ligand for targeted imaging of inflammatory plaques by phage display

scientific article

Identification of a novel non-coding mutation in C1qB in a Dutch child with C1q deficiency associated with recurrent infections.

scientific article published on 18 October 2014

Immune modulation of human dendritic cells by complement

scientific article published on 01 October 2007

Immuno-histological analysis of dendritic cells in nasal biopsies of IgA nephropathy patients

scientific article

Immunogenetics and immunology of transplantation in Leiden.

scientific article published on 22 September 2014

Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies

scientific article published on November 2005

In vitro-generated DC with tolerogenic functions: perspectives for in vivo cellular therapy

scientific article published on 01 January 2011

Increased IL-10 production by stimulated whole blood cultures in primary IgA nephropathy ⬇️

scientific article published on February 1, 1998

Increased influx of myeloid dendritic cells during acute rejection is associated with interstitial fibrosis and tubular atrophy and predicts poor outcome

scientific article published on 24 August 2011

Induction of donor-specific T-cell hyporesponsiveness using dexamethasone-treated dendritic cells in two fully mismatched rat kidney transplantation models

scientific article published on 01 November 2008

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species.

scientific article

Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms.

scientific article

Infiltrating dendritic cells contribute to local synthesis of C1q in murine and human lupus nephritis

scientific article

Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells

scientific article published in December 2004

Injection of recombinant FcalphaRI/CD89 in mice does not induce mesangial IgA deposition

scientific article published on 31 August 2004

Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion

scientific article

Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production

scientific article published on May 1, 1992

Intrinsically Distinct Role of Neutrophil Extracellular Trap Formation in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Compared to Systemic Lupus Erythematosus

scientific article published on 09 November 2019

Introducing this special issue

scientific article published in November 2015

Kidney injury molecule-1 staining in renal allograft biopsies 10 days after transplantation is inversely correlated with functioning proximal tubular epithelial cells.

scientific article published on 16 October 2017

Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

scientific article published on 20 December 2019

Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection

scientific article published on 01 April 2020

Local delivery of liposomal prednisolone leads to an anti-inflammatory profile in renal ischaemia-reperfusion injury in the rat.

scientific article

Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results

scientific article published on 27 June 2020

Low incidence of IgA isotype of HLA antibodies in alloantigen exposed individuals

scientific article published on 23 November 2020

Low pretransplantation mannose-binding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantation

scientific article

MIP-3alpha/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection

scientific article published on 01 September 2005

Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction

scientific article published on 14 September 2015

Mannan-Binding Lectin Mediates Renal Ischemia/Reperfusion Injury Independent of Complement Activation ⬇️

scientific article published on 06 January 2012

Maturation of dendritic cells abrogates C1q production in vivo and in vitro

scientific article published on 15 January 2004

Measuring plasma C4D to monitor immune complexes in lupus nephritis

scientific article published on 03 June 2019

Mechanism of steroid action in renal epithelial cells

scientific article published on May 2004

Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical trials.

scientific article published on August 2013

Mesenchymal Stromal Cell Therapy for Solid Organ Transplantation.

scientific article

Mesenchymal stromal cells in clinical kidney transplantation: how tolerant can it be?

scientific article

Mini-review: A pivotal role for innate immunity in the clearance of apoptotic cells

scientific article

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

scientific article published in January 2017

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

scientific article

Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin

scientific article published on 16 March 2016

Monomeric and polymeric IgA show a similar association with the myeloid FcalphaRI/CD89

scientific article published on 03 May 2006

Myeloperoxidase directs properdin-mediated complement activation.

scientific article

NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinase

scientific article

Natural IgM antibodies are involved in the activation of complement by hypoxic human tubular cells

scientific article published on 2 February 2011

Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney

scientific article

No increase in Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin excretion following intravenous contrast enhanced-CT.

scientific article published on 15 March 2015

No prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery

scientific article published on 09 March 2012

Non-HLA humoral immunity and chronic kidney-graft loss

scientific article published on 01 April 2005

Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation

scientific article published on 19 August 2011

Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells

scientific article published on 01 September 2004

PRAME-Specific Allo-HLA-Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer

article

Pathogenesis of chronic allograft rejection

scientific article

Phagocytosis of apoptotic or necrotic cells differentially regulates the transcriptional expression of IL-12 family members in dendritic cells

scientific article published on 29 April 2014

Pitfalls in urinary complement measurements

scientific article published on 16 June 2012

Production of Inflammatory Mediators and Cytokine Responsiveness of an SV40-Transformed Human Proximal Tubular Epithelial Cell Line ⬇️

scientific article published on 01 May 1998

Production of inflammatory mediators by renal epithelial cells is insensitive to glucocorticoids

scientific article published on September 2002

Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-γ.

scientific article published on 20 January 2017

Properdin binds independent of complement activation in an in vivo model of anti-glomerular basement membrane disease

scientific article published on 12 October 2018

Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activation

scientific article

Proteinase-3-anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) predict relapses in ANCA-associated vasculitis patients after rituximab

scientific article published on 30 June 2020

Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease

scientific article published on 3 March 2016

Purification and functional analysis of human properdin

scientific article published on 01 January 2014

Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression

scientific article

Quantitative polymerase chain reaction profiling of immunomarkers in rejecting kidney allografts for predicting response to steroid treatment

scientific article published on 01 September 2012

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

scientific article published on 26 September 2002

Recognition and clearance of apoptotic cells: a role for complement and pentraxins

scientific article

Recommendations for the management of patients with immune-mediated kidney disease during the severe acute respiratory syndrome coronavirus 2 pandemic

scientific article published on 23 May 2020

Redefining Strategies to Introduce Tolerance-Inducing Cellular Therapy in Human beings to Combat Autoimmunity and Transplantation Reactions

scientific article published on 15 August 2014

Renal ischemia-reperfusion induces a dysbalance of angiopoietins, accompanied by proliferation of pericytes and fibrosis.

scientific article published on 3 July 2013

Renal ischemia-reperfusion induces release of angiopoietin-2 from human grafts of living and deceased donors.

scientific article published in August 2013

Renal tubular epithelial cell death and cyclosporin A.

scientific article published on July 2002

Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1.

scientific article published on November 2005

Reversible differentiation of pro- and anti-inflammatory macrophages

scientific article published in September 2012

Role of complement in IgA nephropathy

scientific article

Role of macromolecular IgA in IgA nephropathy

scientific article

Role of properdin in complement-mediated kidney diseases

scientific article published on 01 May 2019

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study

scientific article

Secretion of collagen type IV by human renal fibroblasts is increased by high glucose via a TGF-beta-independent pathway

scientific article

Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components.

scientific article published on 20 June 2016

Simultaneous pancreas-kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression.

scientific article published on 15 January 2016

Stem Cell Therapy for Glomerular Disease

scientific article published on 12 July 2006

Steroid responsiveness of renal epithelial cells. Dissociation of transrepression and transactivation

scientific article published on 31 October 2002

Subsets of human type 2 macrophages show differential capacity to produce reactive oxygen species

scientific article published on 18 July 2013

Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.

scientific article published on 21 August 2017

Systemic complement activation in central serous chorioretinopathy.

scientific article published on 3 July 2017

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis.

scientific article

Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation

scientific article published on 10 January 2020

Telomere shortening and cellular senescence in a model of chronic renal allograft rejection

scientific article published on April 2003

The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease

scientific article

The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus

scientific article published on 7 April 2018

The NOX2-mediated ROS producing capacity of recipient cells is associated with reduced T cell infiltrate in an experimental model of chronic renal allograft inflammation

scientific article published on 21 December 2013

The complement inhibitor low molecular weight dextran sulfate prevents TLR4-induced phenotypic and functional maturation of human dendritic cells

scientific article published in July 2008

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment.

scientific article

The functional polymorphism Ala258Ser in the innate receptor gene ficolin-2 in the donor predicts improved renal transplant outcome

scientific article published in September 2012

The human kidney capsule contains a functionally distinct mesenchymal stromal cell population.

scientific article published on 5 December 2017

The interplay between antiviral immunity and allo-immune reactivity after renal transplantation: consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR).

scientific article published on 17 September 2014

The novel cyclophilin-binding drug sanglifehrin A specifically affects antigen uptake receptor expression and endocytic capacity of human dendritic cells

scientific article

The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated aging

scientific article published on May 2004

The role of secretory IgA and complement in IgA nephropathy

scientific article published on January 2008

Tissue specificity of cross-reactive allogeneic responses by EBV EBNA3A-specific memory T cells

scientific article published in March 2011

Transforming growth factor-β1 regulates chemokine and complement production by human proximal tubular epithelial cells ⬇️

scientific article published on March 1, 1998

Uptake of HLA Alloantigens via CD89 and CD206 Does Not Enhance Antigen Presentation by Indirect Allorecognition.

scientific article published on 20 June 2016

Urinary TIMP-2 predicts the presence and duration of delayed graft function in donation after circulatory death kidney transplant recipients

article

Vaccine-induced allo-HLA-reactive memory T cells in a kidney transplantation candidate

scientific article published on March 2011

Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell–derived endothelium

scientific article published on 10 January 2019

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